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Immunomodulatory effects of lactoferrin.

Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q - Acta Pharmacol. Sin. (2014)

Bottom Line: Lf is also considered a cell-secreted mediator that bridges the innate and adaptive immune responses.In the recent years much has been learned about the mechanisms by which Lf exerts its activities.This review summarizes the recent advances in understanding the mechanisms underlying the multifunctional roles of Lf, and provides a future perspective on its potential prophylactic and therapeutic applications.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Inmunología, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito 1, Nuevo Campus Universitario, CP 31125, Chihuahua, México.

ABSTRACT
Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bind and sequester lipopolysaccharides, thus preventing pro-inflammatory pathway activation, sepsis and tissue damages. Lf is also considered a cell-secreted mediator that bridges the innate and adaptive immune responses. In the recent years much has been learned about the mechanisms by which Lf exerts its activities. This review summarizes the recent advances in understanding the mechanisms underlying the multifunctional roles of Lf, and provides a future perspective on its potential prophylactic and therapeutic applications.

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Related in: MedlinePlus

Schematic representation of the influence of host Lf on immune cells. (a) Promotes B- and T-lymphocyte maturation; (b) Negative regulation of B-lymphocytes through LPS binding; (c) B- and T-lymphocyte interaction; (d) induces IgA and IgG secretion; (e) promotes T-lymphocyte proliferation; (f) decreases IL5 and IL10 secretion; (g) down regulates NFκβ activation of monocytes; (h) enhances the phagocytic activity of macrophages; and (i) prevents the interaction between LPS and CD14 as a TLR4. B, B lymphocytes; T, T lymphocytes; Mf, macrophages; Mon, Monocytes; Neu, Neutrophils.
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fig2: Schematic representation of the influence of host Lf on immune cells. (a) Promotes B- and T-lymphocyte maturation; (b) Negative regulation of B-lymphocytes through LPS binding; (c) B- and T-lymphocyte interaction; (d) induces IgA and IgG secretion; (e) promotes T-lymphocyte proliferation; (f) decreases IL5 and IL10 secretion; (g) down regulates NFκβ activation of monocytes; (h) enhances the phagocytic activity of macrophages; and (i) prevents the interaction between LPS and CD14 as a TLR4. B, B lymphocytes; T, T lymphocytes; Mf, macrophages; Mon, Monocytes; Neu, Neutrophils.

Mentions: The ability of Lf to promote antigen-specific delayed-type hypersensitivity (DTH) responses and to activate bacillus Calmette-Guerin (Mycobacterium strain) (BCG)-specific T cells suggests that Lf plays a role in the initiation of T-cell activation through the modulation of dendritic cell function68. Dendritic cells possess Lf receptors because bovine and human Lf binds to the surface of peripheral blood-derived dendritic cells69. The ability of dendritic cells to migrate upon antigen stimulation or capture is essential in the promotion of antigen-specific immune responses70. Lf acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses. It has also been reported as a novel maturation factor for human dendritic cells10,71. Lf is a strong mediator of dendritic cell function. This observation, together with the above-described impact on Mfs, suggests that Lf exerts its effect on cells involved in the commitment of pathogens (antigens) and can direct the development of adaptive immunity (Figure 2).


Immunomodulatory effects of lactoferrin.

Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q - Acta Pharmacol. Sin. (2014)

Schematic representation of the influence of host Lf on immune cells. (a) Promotes B- and T-lymphocyte maturation; (b) Negative regulation of B-lymphocytes through LPS binding; (c) B- and T-lymphocyte interaction; (d) induces IgA and IgG secretion; (e) promotes T-lymphocyte proliferation; (f) decreases IL5 and IL10 secretion; (g) down regulates NFκβ activation of monocytes; (h) enhances the phagocytic activity of macrophages; and (i) prevents the interaction between LPS and CD14 as a TLR4. B, B lymphocytes; T, T lymphocytes; Mf, macrophages; Mon, Monocytes; Neu, Neutrophils.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4814036&req=5

fig2: Schematic representation of the influence of host Lf on immune cells. (a) Promotes B- and T-lymphocyte maturation; (b) Negative regulation of B-lymphocytes through LPS binding; (c) B- and T-lymphocyte interaction; (d) induces IgA and IgG secretion; (e) promotes T-lymphocyte proliferation; (f) decreases IL5 and IL10 secretion; (g) down regulates NFκβ activation of monocytes; (h) enhances the phagocytic activity of macrophages; and (i) prevents the interaction between LPS and CD14 as a TLR4. B, B lymphocytes; T, T lymphocytes; Mf, macrophages; Mon, Monocytes; Neu, Neutrophils.
Mentions: The ability of Lf to promote antigen-specific delayed-type hypersensitivity (DTH) responses and to activate bacillus Calmette-Guerin (Mycobacterium strain) (BCG)-specific T cells suggests that Lf plays a role in the initiation of T-cell activation through the modulation of dendritic cell function68. Dendritic cells possess Lf receptors because bovine and human Lf binds to the surface of peripheral blood-derived dendritic cells69. The ability of dendritic cells to migrate upon antigen stimulation or capture is essential in the promotion of antigen-specific immune responses70. Lf acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses. It has also been reported as a novel maturation factor for human dendritic cells10,71. Lf is a strong mediator of dendritic cell function. This observation, together with the above-described impact on Mfs, suggests that Lf exerts its effect on cells involved in the commitment of pathogens (antigens) and can direct the development of adaptive immunity (Figure 2).

Bottom Line: Lf is also considered a cell-secreted mediator that bridges the innate and adaptive immune responses.In the recent years much has been learned about the mechanisms by which Lf exerts its activities.This review summarizes the recent advances in understanding the mechanisms underlying the multifunctional roles of Lf, and provides a future perspective on its potential prophylactic and therapeutic applications.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Inmunología, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito 1, Nuevo Campus Universitario, CP 31125, Chihuahua, México.

ABSTRACT
Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bind and sequester lipopolysaccharides, thus preventing pro-inflammatory pathway activation, sepsis and tissue damages. Lf is also considered a cell-secreted mediator that bridges the innate and adaptive immune responses. In the recent years much has been learned about the mechanisms by which Lf exerts its activities. This review summarizes the recent advances in understanding the mechanisms underlying the multifunctional roles of Lf, and provides a future perspective on its potential prophylactic and therapeutic applications.

Show MeSH
Related in: MedlinePlus