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Jumping the Gun: Mapping Neural Correlates of Waiting Impulsivity and Relevance Across Alcohol Misuse.

Morris LS, Kundu P, Baek K, Irvine MA, Mechelmans DJ, Wood J, Harrison NA, Robbins TW, Bullmore ET, Voon V - Biol. Psychiatry (2015)

Bottom Line: Waiting impulsivity was associated with lower connectivity of the subthalamic nucleus with ventral striatum and subgenual cingulate, regions similarly implicated in rodent lesion studies.Using machine learning techniques we showed that subthalamic connectivity differentiates binge drinkers and individuals with alcohol use disorders from healthy volunteers.We highlight the translational and clinical relevance of dissociable functional systems of cortical, striatal, and hyperdirect connections with the subthalamic nucleus in modulating waiting and stopping and their importance across dimensions of alcohol misuse.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Cambridge; Behavioural and Clinical Neuroscience Institute, University of Cambridge.

No MeSH data available.


Related in: MedlinePlus

Waiting impulsivity in binge drinkers. (A) The 4-choice serial reaction time task. The cue onset prompted subjects to hold down the space bar. A green circle target appeared, to which subjects responded by releasing the space bar and touching the box on the touch screen in which the target appeared. Finally, monetary feedback was displayed. Premature responding was defined as release of the space bar before target onset. (B) Number of premature responses of healthy volunteers (HV) and binge drinkers (BD); error bars are standard error of the mean; *indicates p < .05.
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f0005: Waiting impulsivity in binge drinkers. (A) The 4-choice serial reaction time task. The cue onset prompted subjects to hold down the space bar. A green circle target appeared, to which subjects responded by releasing the space bar and touching the box on the touch screen in which the target appeared. Finally, monetary feedback was displayed. Premature responding was defined as release of the space bar before target onset. (B) Number of premature responses of healthy volunteers (HV) and binge drinkers (BD); error bars are standard error of the mean; *indicates p < .05.

Mentions: The 4-CSRT task (Figure 1) was developed based on the rodent 5-CSRT. When four boxes appeared on the screen, subjects held down the space bar on the keyboard with their dominant index finger, indicating the cue onset time. After a specified period (cue-target interval), a green circle target appeared briefly and randomly in one of the four boxes. Subjects released the space bar and touched the box in which the target appeared. Premature responding was defined as early release of the space bar before target onset. Supplement 1 includes further task details.


Jumping the Gun: Mapping Neural Correlates of Waiting Impulsivity and Relevance Across Alcohol Misuse.

Morris LS, Kundu P, Baek K, Irvine MA, Mechelmans DJ, Wood J, Harrison NA, Robbins TW, Bullmore ET, Voon V - Biol. Psychiatry (2015)

Waiting impulsivity in binge drinkers. (A) The 4-choice serial reaction time task. The cue onset prompted subjects to hold down the space bar. A green circle target appeared, to which subjects responded by releasing the space bar and touching the box on the touch screen in which the target appeared. Finally, monetary feedback was displayed. Premature responding was defined as release of the space bar before target onset. (B) Number of premature responses of healthy volunteers (HV) and binge drinkers (BD); error bars are standard error of the mean; *indicates p < .05.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4764648&req=5

f0005: Waiting impulsivity in binge drinkers. (A) The 4-choice serial reaction time task. The cue onset prompted subjects to hold down the space bar. A green circle target appeared, to which subjects responded by releasing the space bar and touching the box on the touch screen in which the target appeared. Finally, monetary feedback was displayed. Premature responding was defined as release of the space bar before target onset. (B) Number of premature responses of healthy volunteers (HV) and binge drinkers (BD); error bars are standard error of the mean; *indicates p < .05.
Mentions: The 4-CSRT task (Figure 1) was developed based on the rodent 5-CSRT. When four boxes appeared on the screen, subjects held down the space bar on the keyboard with their dominant index finger, indicating the cue onset time. After a specified period (cue-target interval), a green circle target appeared briefly and randomly in one of the four boxes. Subjects released the space bar and touched the box in which the target appeared. Premature responding was defined as early release of the space bar before target onset. Supplement 1 includes further task details.

Bottom Line: Waiting impulsivity was associated with lower connectivity of the subthalamic nucleus with ventral striatum and subgenual cingulate, regions similarly implicated in rodent lesion studies.Using machine learning techniques we showed that subthalamic connectivity differentiates binge drinkers and individuals with alcohol use disorders from healthy volunteers.We highlight the translational and clinical relevance of dissociable functional systems of cortical, striatal, and hyperdirect connections with the subthalamic nucleus in modulating waiting and stopping and their importance across dimensions of alcohol misuse.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Cambridge; Behavioural and Clinical Neuroscience Institute, University of Cambridge.

No MeSH data available.


Related in: MedlinePlus