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Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer.

Chomachayi MD, Solouk A, Mirzadeh H - Prog Biomater (2016)

Bottom Line: The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively.The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site.Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

View Article: PubMed Central - PubMed

Affiliation: Polymer Engineering and Color Technology Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.

ABSTRACT

In this study, silk fibroin was extracted from cocoons of silkworms and fabricated into nonwoven mats by electrospinning method. A new model based on the group method of data handling (GMDH) and artificial neural network (ANN) was developed for estimation of the average diameter of electrospun silk fibroin nanofibers. In this regard, concentration, flow rate, voltage, distance, and speed of collector were used as input parameters and average diameter of the fibers was considered as output parameter. Two models were capable to estimate average diameter of fibers with good accuracy. The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively. Furthermore, due to importance of oxygen delivery to site of injury to promote wound healing, continuity equation for mass transport was employed for prediction of oxygen profile in the system containing wound dressing and skin. The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site. Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

No MeSH data available.


Related in: MedlinePlus

Three-dimensional oxygen profile in wound dressing and skin system (relationship between oxygen concentration and skin + wound dressing)
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Fig13: Three-dimensional oxygen profile in wound dressing and skin system (relationship between oxygen concentration and skin + wound dressing)

Mentions: The result of solving the equations is presented in Fig. 13. The figure is shown the oxygen profile after 1 day that wound dress is attached to the skin. As can be seen, oxygen can be suitably diffuse on the wound dress and reach to the skin layer for consumption by cells. It should be noted that last layer of skin is more sensitive to the oxygen because the magnitude of oxygen has its lower value in this region. The lower magnitude of oxygen in last layer of skin is logical because the problem is diffusion control. It means the only mechanism to transport oxygen is diffusion mass transfer which should be contest with the oxygen consumption of cells. However, the figure shows that diffusion of oxygen in our proposed wound dress is appropriate for transporting of oxygen to even the last layer of skin.Fig. 13


Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer.

Chomachayi MD, Solouk A, Mirzadeh H - Prog Biomater (2016)

Three-dimensional oxygen profile in wound dressing and skin system (relationship between oxygen concentration and skin + wound dressing)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4764634&req=5

Fig13: Three-dimensional oxygen profile in wound dressing and skin system (relationship between oxygen concentration and skin + wound dressing)
Mentions: The result of solving the equations is presented in Fig. 13. The figure is shown the oxygen profile after 1 day that wound dress is attached to the skin. As can be seen, oxygen can be suitably diffuse on the wound dress and reach to the skin layer for consumption by cells. It should be noted that last layer of skin is more sensitive to the oxygen because the magnitude of oxygen has its lower value in this region. The lower magnitude of oxygen in last layer of skin is logical because the problem is diffusion control. It means the only mechanism to transport oxygen is diffusion mass transfer which should be contest with the oxygen consumption of cells. However, the figure shows that diffusion of oxygen in our proposed wound dress is appropriate for transporting of oxygen to even the last layer of skin.Fig. 13

Bottom Line: The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively.The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site.Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

View Article: PubMed Central - PubMed

Affiliation: Polymer Engineering and Color Technology Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.

ABSTRACT

In this study, silk fibroin was extracted from cocoons of silkworms and fabricated into nonwoven mats by electrospinning method. A new model based on the group method of data handling (GMDH) and artificial neural network (ANN) was developed for estimation of the average diameter of electrospun silk fibroin nanofibers. In this regard, concentration, flow rate, voltage, distance, and speed of collector were used as input parameters and average diameter of the fibers was considered as output parameter. Two models were capable to estimate average diameter of fibers with good accuracy. The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively. Furthermore, due to importance of oxygen delivery to site of injury to promote wound healing, continuity equation for mass transport was employed for prediction of oxygen profile in the system containing wound dressing and skin. The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site. Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

No MeSH data available.


Related in: MedlinePlus