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Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer.

Chomachayi MD, Solouk A, Mirzadeh H - Prog Biomater (2016)

Bottom Line: The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively.The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site.Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

View Article: PubMed Central - PubMed

Affiliation: Polymer Engineering and Color Technology Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.

ABSTRACT

In this study, silk fibroin was extracted from cocoons of silkworms and fabricated into nonwoven mats by electrospinning method. A new model based on the group method of data handling (GMDH) and artificial neural network (ANN) was developed for estimation of the average diameter of electrospun silk fibroin nanofibers. In this regard, concentration, flow rate, voltage, distance, and speed of collector were used as input parameters and average diameter of the fibers was considered as output parameter. Two models were capable to estimate average diameter of fibers with good accuracy. The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively. Furthermore, due to importance of oxygen delivery to site of injury to promote wound healing, continuity equation for mass transport was employed for prediction of oxygen profile in the system containing wound dressing and skin. The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site. Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

No MeSH data available.


Related in: MedlinePlus

SEM images and diameter distributions of electrospun nanofibers of silk fibroin under different flow rates: a 0.3 cc/h, b 0.5 cc/h, c 0.6 cc/h (concentration 12 %, voltage 22 kV and collection distance 12 cm). Scale bars 5 µm
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Fig12: SEM images and diameter distributions of electrospun nanofibers of silk fibroin under different flow rates: a 0.3 cc/h, b 0.5 cc/h, c 0.6 cc/h (concentration 12 %, voltage 22 kV and collection distance 12 cm). Scale bars 5 µm

Mentions: Figure 12 shows the effect of increase in flow rate on fiber diameter. Obviously with increase in the flow rate, more volume of solution is exit from the needle. Therefore, diameter of the fibers is increased. The flow rate has great importance effect on the formation of Taylor’s cone and with increase of flow rate is caused to uniform morphology of silk fibroin nanofibers. Consequently, flow rate is a key parameter for obtaining an appropriate structure in electrospinning (Megelski et al. 2002).Fig. 12


Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer.

Chomachayi MD, Solouk A, Mirzadeh H - Prog Biomater (2016)

SEM images and diameter distributions of electrospun nanofibers of silk fibroin under different flow rates: a 0.3 cc/h, b 0.5 cc/h, c 0.6 cc/h (concentration 12 %, voltage 22 kV and collection distance 12 cm). Scale bars 5 µm
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4764634&req=5

Fig12: SEM images and diameter distributions of electrospun nanofibers of silk fibroin under different flow rates: a 0.3 cc/h, b 0.5 cc/h, c 0.6 cc/h (concentration 12 %, voltage 22 kV and collection distance 12 cm). Scale bars 5 µm
Mentions: Figure 12 shows the effect of increase in flow rate on fiber diameter. Obviously with increase in the flow rate, more volume of solution is exit from the needle. Therefore, diameter of the fibers is increased. The flow rate has great importance effect on the formation of Taylor’s cone and with increase of flow rate is caused to uniform morphology of silk fibroin nanofibers. Consequently, flow rate is a key parameter for obtaining an appropriate structure in electrospinning (Megelski et al. 2002).Fig. 12

Bottom Line: The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively.The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site.Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

View Article: PubMed Central - PubMed

Affiliation: Polymer Engineering and Color Technology Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.

ABSTRACT

In this study, silk fibroin was extracted from cocoons of silkworms and fabricated into nonwoven mats by electrospinning method. A new model based on the group method of data handling (GMDH) and artificial neural network (ANN) was developed for estimation of the average diameter of electrospun silk fibroin nanofibers. In this regard, concentration, flow rate, voltage, distance, and speed of collector were used as input parameters and average diameter of the fibers was considered as output parameter. Two models were capable to estimate average diameter of fibers with good accuracy. The average absolute relative deviation for GMDH and ANN models was equal to 3.56 and 2.28 %, respectively. Furthermore, due to importance of oxygen delivery to site of injury to promote wound healing, continuity equation for mass transport was employed for prediction of oxygen profile in the system containing wound dressing and skin. The result showed that our prepared wound dressing is capable to pass the oxygen completely to the skin layer and is not acting as a barrier for oxygen delivery to wound site. Since average nanofibers diameter can influence the mat physical, mechanical and biological properties then this model may serve as a useful guide to obtain tailor made and uniform silk nanofibers at various combinations of process variables.

No MeSH data available.


Related in: MedlinePlus