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Genetic association of PROC variants with pulmonary embolism in Northern Chinese Han population.

Wang Z, Wang T, Chang J, Li H, Wang C, Li Y, Lang X, Jing S, Zhang G, Wang Y - Springerplus (2016)

Bottom Line: The allele frequency of rs199469469 was significantly different between PE patients and the control [OR (95 % CI) = 5.00 (1.66-15.12), P = 0.004], and the difference remained significantly after controlling for age and gender [OR (95 % CI) = 5.34 (1.47-19.39), P = 0.011).Our study reports that PROC SNPs (rs199469469) might be associated with PE susceptibility, with the G allele of rs199469469 serving as the protective factors for incidence of PE.These findings may contribute to the understanding and primary prevention of PE.

View Article: PubMed Central - PubMed

Affiliation: Department of Thorax, Anqiu People's Hospital, Weifang, 262100 China.

ABSTRACT
To evaluate SNPs (single nucleotide polymorphism) in PROC (protein C gene) associated with pulmonary embolism (PE) susceptibility in North Chinese Han population. A case-control study design was used, and patients with PE and healthy participants were enrolled from the Emerging Department of the several hospitals in Weifang, Shandong, China. SNPs in PROC were genotyped using Mass ARRAY system. The allele frequency of rs199469469 was significantly different between PE patients and the control [OR (95 % CI) = 5.00 (1.66-15.12), P = 0.004], and the difference remained significantly after controlling for age and gender [OR (95 % CI) = 5.34 (1.47-19.39), P = 0.011). The G(del)G in the haplotype includes rs1799809/rs199469469/rs2069928 was of a significantly difference (P = 0.016) among PE patients and the controls, and remained significant (P = 0.015) after adjustment for age and sex. Our study reports that PROC SNPs (rs199469469) might be associated with PE susceptibility, with the G allele of rs199469469 serving as the protective factors for incidence of PE. These findings may contribute to the understanding and primary prevention of PE.

No MeSH data available.


Related in: MedlinePlus

Genotyping of six SNPs in PROC gene
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Fig1: Genotyping of six SNPs in PROC gene

Mentions: In total, 101 cases of PE (61 males and 40 females; with median age 63 year-old, ranged 24–85), and 279 healthy controls (187 males and 92 females; with median age 65 year-old, ranged 48–87 year-old) were finally included in the study. Six polymorphisms in the PROC gene were genotyped through Mass ARRAY system, with success rate of 99.7, 96.8, 96.6, 92.1, 97.6 and 97.6% for rs1799809, rs199469469, rs2069928, rs7580688, rs2240817 and rs3771293, respectively (Fig. 1).Fig. 1


Genetic association of PROC variants with pulmonary embolism in Northern Chinese Han population.

Wang Z, Wang T, Chang J, Li H, Wang C, Li Y, Lang X, Jing S, Zhang G, Wang Y - Springerplus (2016)

Genotyping of six SNPs in PROC gene
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4764599&req=5

Fig1: Genotyping of six SNPs in PROC gene
Mentions: In total, 101 cases of PE (61 males and 40 females; with median age 63 year-old, ranged 24–85), and 279 healthy controls (187 males and 92 females; with median age 65 year-old, ranged 48–87 year-old) were finally included in the study. Six polymorphisms in the PROC gene were genotyped through Mass ARRAY system, with success rate of 99.7, 96.8, 96.6, 92.1, 97.6 and 97.6% for rs1799809, rs199469469, rs2069928, rs7580688, rs2240817 and rs3771293, respectively (Fig. 1).Fig. 1

Bottom Line: The allele frequency of rs199469469 was significantly different between PE patients and the control [OR (95 % CI) = 5.00 (1.66-15.12), P = 0.004], and the difference remained significantly after controlling for age and gender [OR (95 % CI) = 5.34 (1.47-19.39), P = 0.011).Our study reports that PROC SNPs (rs199469469) might be associated with PE susceptibility, with the G allele of rs199469469 serving as the protective factors for incidence of PE.These findings may contribute to the understanding and primary prevention of PE.

View Article: PubMed Central - PubMed

Affiliation: Department of Thorax, Anqiu People's Hospital, Weifang, 262100 China.

ABSTRACT
To evaluate SNPs (single nucleotide polymorphism) in PROC (protein C gene) associated with pulmonary embolism (PE) susceptibility in North Chinese Han population. A case-control study design was used, and patients with PE and healthy participants were enrolled from the Emerging Department of the several hospitals in Weifang, Shandong, China. SNPs in PROC were genotyped using Mass ARRAY system. The allele frequency of rs199469469 was significantly different between PE patients and the control [OR (95 % CI) = 5.00 (1.66-15.12), P = 0.004], and the difference remained significantly after controlling for age and gender [OR (95 % CI) = 5.34 (1.47-19.39), P = 0.011). The G(del)G in the haplotype includes rs1799809/rs199469469/rs2069928 was of a significantly difference (P = 0.016) among PE patients and the controls, and remained significant (P = 0.015) after adjustment for age and sex. Our study reports that PROC SNPs (rs199469469) might be associated with PE susceptibility, with the G allele of rs199469469 serving as the protective factors for incidence of PE. These findings may contribute to the understanding and primary prevention of PE.

No MeSH data available.


Related in: MedlinePlus