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The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution.

Wang GZ, Cheng X, Zhou B, Wen ZS, Huang YC, Chen HB, Li GF, Huang ZL, Zhou YC, Feng L, Wei MM, Qu LW, Cao Y, Zhou GB - Elife (2015)

Bottom Line: Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients.CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke.Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier estimates of survival of patients with non-small cell lung cancer (NSCLC) according to age, cancer stage, and histology.DOI:http://dx.doi.org/10.7554/eLife.09419.005
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fig1s1: Kaplan–Meier estimates of survival of patients with non-small cell lung cancer (NSCLC) according to age, cancer stage, and histology.DOI:http://dx.doi.org/10.7554/eLife.09419.005

Mentions: We showed patients of both HPR and CR regions with relatively earlier disease (stages I and II) had lower CXCL13, while those with advanced disease (stages III and IV) had higher CXCL13 (Figure 1K), and multivariate logistic analyses showed that CXCL13-high was associated with TNM stage (Table 2, p=0.003). In 54 CR patients whose survival information was available (Table 3), the median survival time of CXCL13-high patients (965 days) was much shorter than the CXCL13-low cases (1193 days, p=0.03; Figure 1L). Kaplan-Meier estimates of survival of patients with NSCLC according to age (Figure 1—figure supplement 1A), cancer stage (Figure 1—figure supplement 1B), and histology (Figure 1—figure supplement 1C) confirmed that patients with stages III–IV lung cancer had shorter survival time than those with earlier stages of NSCLCs.10.7554/eLife.09419.008Table 3.


The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution.

Wang GZ, Cheng X, Zhou B, Wen ZS, Huang YC, Chen HB, Li GF, Huang ZL, Zhou YC, Feng L, Wei MM, Qu LW, Cao Y, Zhou GB - Elife (2015)

Kaplan–Meier estimates of survival of patients with non-small cell lung cancer (NSCLC) according to age, cancer stage, and histology.DOI:http://dx.doi.org/10.7554/eLife.09419.005
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4764582&req=5

fig1s1: Kaplan–Meier estimates of survival of patients with non-small cell lung cancer (NSCLC) according to age, cancer stage, and histology.DOI:http://dx.doi.org/10.7554/eLife.09419.005
Mentions: We showed patients of both HPR and CR regions with relatively earlier disease (stages I and II) had lower CXCL13, while those with advanced disease (stages III and IV) had higher CXCL13 (Figure 1K), and multivariate logistic analyses showed that CXCL13-high was associated with TNM stage (Table 2, p=0.003). In 54 CR patients whose survival information was available (Table 3), the median survival time of CXCL13-high patients (965 days) was much shorter than the CXCL13-low cases (1193 days, p=0.03; Figure 1L). Kaplan-Meier estimates of survival of patients with NSCLC according to age (Figure 1—figure supplement 1A), cancer stage (Figure 1—figure supplement 1B), and histology (Figure 1—figure supplement 1C) confirmed that patients with stages III–IV lung cancer had shorter survival time than those with earlier stages of NSCLCs.10.7554/eLife.09419.008Table 3.

Bottom Line: Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients.CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke.Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis.

No MeSH data available.


Related in: MedlinePlus