Limits...
Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.

Berger GE, Smesny S, Schäfer MR, Milleit B, Langbein K, Hipler UC, Milleit C, Klier CM, Schlögelhofer M, Holub M, Holzer I, Berk M, McGorry PD, Sauer H, Amminger GP - PLoS ONE (2016)

Bottom Line: Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups.As expected, niacin sensitivity of FEP was attenuated compared to HC group.Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level.

View Article: PubMed Central - PubMed

Affiliation: University Hospital of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland.

ABSTRACT

Background: Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders.

Methods: We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics.

Results: Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (inPLA2) activity, a marker of membrane lipid repair/remodelling.

Conclusions: Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a "pro-inflammatory state", whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated.

Show MeSH

Related in: MedlinePlus

Illustration of group differences of niacin scores between non-transition (NT) and transition (T) UHR patients, first-episode psychosis patients (FEP) and healthy controls (HC).Due to obvious (although not significant) differences in gender distribution between groups and previously reported effects of gender on niacin skin sensitivity, results are presented separately for males and females. ** p<0.01.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4764507&req=5

pone.0148429.g001: Illustration of group differences of niacin scores between non-transition (NT) and transition (T) UHR patients, first-episode psychosis patients (FEP) and healthy controls (HC).Due to obvious (although not significant) differences in gender distribution between groups and previously reported effects of gender on niacin skin sensitivity, results are presented separately for males and females. ** p<0.01.

Mentions: Results of the post-hoc analyses corrected for multiple comparisons (Bonferroni) are summarized in Table 3. In general, niacin sensitivity of UHR individuals irrespective of the transition outcome was significantly higher than in HC (and in FEP). This finding seems to be even more pronounced in females. An illustration of the findings in total niacin scores of males and females is given in Fig 1. As a replication of previous findings, in all but the lowest concentration’s (0.0001M) sum scores, the flush response was significantly lower in FEP than in HC, equally apparent in males and females.


Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.

Berger GE, Smesny S, Schäfer MR, Milleit B, Langbein K, Hipler UC, Milleit C, Klier CM, Schlögelhofer M, Holub M, Holzer I, Berk M, McGorry PD, Sauer H, Amminger GP - PLoS ONE (2016)

Illustration of group differences of niacin scores between non-transition (NT) and transition (T) UHR patients, first-episode psychosis patients (FEP) and healthy controls (HC).Due to obvious (although not significant) differences in gender distribution between groups and previously reported effects of gender on niacin skin sensitivity, results are presented separately for males and females. ** p<0.01.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4764507&req=5

pone.0148429.g001: Illustration of group differences of niacin scores between non-transition (NT) and transition (T) UHR patients, first-episode psychosis patients (FEP) and healthy controls (HC).Due to obvious (although not significant) differences in gender distribution between groups and previously reported effects of gender on niacin skin sensitivity, results are presented separately for males and females. ** p<0.01.
Mentions: Results of the post-hoc analyses corrected for multiple comparisons (Bonferroni) are summarized in Table 3. In general, niacin sensitivity of UHR individuals irrespective of the transition outcome was significantly higher than in HC (and in FEP). This finding seems to be even more pronounced in females. An illustration of the findings in total niacin scores of males and females is given in Fig 1. As a replication of previous findings, in all but the lowest concentration’s (0.0001M) sum scores, the flush response was significantly lower in FEP than in HC, equally apparent in males and females.

Bottom Line: Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups.As expected, niacin sensitivity of FEP was attenuated compared to HC group.Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level.

View Article: PubMed Central - PubMed

Affiliation: University Hospital of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland.

ABSTRACT

Background: Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders.

Methods: We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics.

Results: Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (inPLA2) activity, a marker of membrane lipid repair/remodelling.

Conclusions: Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a "pro-inflammatory state", whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated.

Show MeSH
Related in: MedlinePlus