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Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin.

Gerasimov AV, Varfolomeev MA, Ziganshin MA, Gorbatchuk VV, Rakipov IT, Klimovitskii AE, Usmanova LS - J Adv Pharm Technol Res (2016 Jan-Mar)

Bottom Line: Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme.It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400.Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008, Russia.

ABSTRACT
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers.

No MeSH data available.


Related in: MedlinePlus

Infrared-spectra of phenacetin composites with Pluronic-F127 (a), polyethylene glycol-1000 (c) and polyethylene glycol-1400 (e) obtained at a ratio of 1:1, 1:6, 1:10 in the wavenumber range of 400 to 4000 cm−1 and an enlarged portion of the spectrum of phenacetin composites with Pluronic-F127 (b), polyethylene glycol-1000 (d) and polyethylene glycol-1400 (f) in the wavenumber range of 1600 to 1700 cm−1
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Figure 6: Infrared-spectra of phenacetin composites with Pluronic-F127 (a), polyethylene glycol-1000 (c) and polyethylene glycol-1400 (e) obtained at a ratio of 1:1, 1:6, 1:10 in the wavenumber range of 400 to 4000 cm−1 and an enlarged portion of the spectrum of phenacetin composites with Pluronic-F127 (b), polyethylene glycol-1000 (d) and polyethylene glycol-1400 (f) in the wavenumber range of 1600 to 1700 cm−1

Mentions: To evaluate the proportion of free and H-bonded molecules of phenacetin in the studied mixtures, the method of infrared (IR)-spectroscopy was used. IR-spectra of the solid samples of PEG-1000, PEG-1400, Pluronic-F127, phenacetin and their solid mixtures are presented in Figures 5–6.


Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin.

Gerasimov AV, Varfolomeev MA, Ziganshin MA, Gorbatchuk VV, Rakipov IT, Klimovitskii AE, Usmanova LS - J Adv Pharm Technol Res (2016 Jan-Mar)

Infrared-spectra of phenacetin composites with Pluronic-F127 (a), polyethylene glycol-1000 (c) and polyethylene glycol-1400 (e) obtained at a ratio of 1:1, 1:6, 1:10 in the wavenumber range of 400 to 4000 cm−1 and an enlarged portion of the spectrum of phenacetin composites with Pluronic-F127 (b), polyethylene glycol-1000 (d) and polyethylene glycol-1400 (f) in the wavenumber range of 1600 to 1700 cm−1
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4759984&req=5

Figure 6: Infrared-spectra of phenacetin composites with Pluronic-F127 (a), polyethylene glycol-1000 (c) and polyethylene glycol-1400 (e) obtained at a ratio of 1:1, 1:6, 1:10 in the wavenumber range of 400 to 4000 cm−1 and an enlarged portion of the spectrum of phenacetin composites with Pluronic-F127 (b), polyethylene glycol-1000 (d) and polyethylene glycol-1400 (f) in the wavenumber range of 1600 to 1700 cm−1
Mentions: To evaluate the proportion of free and H-bonded molecules of phenacetin in the studied mixtures, the method of infrared (IR)-spectroscopy was used. IR-spectra of the solid samples of PEG-1000, PEG-1400, Pluronic-F127, phenacetin and their solid mixtures are presented in Figures 5–6.

Bottom Line: Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme.It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400.Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008, Russia.

ABSTRACT
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers.

No MeSH data available.


Related in: MedlinePlus