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Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin.

Gerasimov AV, Varfolomeev MA, Ziganshin MA, Gorbatchuk VV, Rakipov IT, Klimovitskii AE, Usmanova LS - J Adv Pharm Technol Res (2016 Jan-Mar)

Bottom Line: Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme.It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400.Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008, Russia.

ABSTRACT
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers.

No MeSH data available.


Related in: MedlinePlus

The ratio of the enthalpy of interaction polymer-phenacetin calculated according to the Eq. (4), to the mixture composition
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Related In: Results  -  Collection

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Figure 2: The ratio of the enthalpy of interaction polymer-phenacetin calculated according to the Eq. (4), to the mixture composition

Mentions: The calculated ΔintHpol/phenacetin values are presented in Table 2 and Figure 2.


Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin.

Gerasimov AV, Varfolomeev MA, Ziganshin MA, Gorbatchuk VV, Rakipov IT, Klimovitskii AE, Usmanova LS - J Adv Pharm Technol Res (2016 Jan-Mar)

The ratio of the enthalpy of interaction polymer-phenacetin calculated according to the Eq. (4), to the mixture composition
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4759984&req=5

Figure 2: The ratio of the enthalpy of interaction polymer-phenacetin calculated according to the Eq. (4), to the mixture composition
Mentions: The calculated ΔintHpol/phenacetin values are presented in Table 2 and Figure 2.

Bottom Line: Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme.It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400.Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008, Russia.

ABSTRACT
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers.

No MeSH data available.


Related in: MedlinePlus