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Relation between detection rate and inappropriate shocks in single versus dual chamber cardioverter-defibrillator--an analysis from the OPTION trial.

Kolb C, Sturmer M, Babuty D, Sick P, Davy JM, Molon G, Schwab JO, Mantovani G, Wickliffe A, Lennerz C, Semmler V, Siot PH, Reif S - Sci Rep (2016)

Bottom Line: The programming of implantable cardioverter-defibrillators (ICDs) influences inappropriate shock rates.In a post-hoc analysis, rates of patients with inappropriate and appropriate shocks were calculated for shocks triggered at heart rates ≥ 170 bpm (ventricular tachycardia zone) and at rates ≥ 200 bpm (ventricular fibrillation zone).The higher frequency of patients with total shocks with SC settings than with DC settings that benefit from PARAD+ was driven by a higher percentage of patients with inappropriate shocks in the VT zone (170-200 bpm) in the SC population.

View Article: PubMed Central - PubMed

Affiliation: Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Abteilung für Elektrophysiologie, Faculty of Medicine, Technische Universität München, Munich, Germany.

ABSTRACT
The programming of implantable cardioverter-defibrillators (ICDs) influences inappropriate shock rates. The aim of the study is to analyse rates of patients with appropriate and inappropriate shocks according to detection zones in the OPTION trial. All patients received dual chamber (DC) ICDs randomly assigned to be programmed either to single chamber (SC) or to DC settings including PARAD+ algorithm. In a post-hoc analysis, rates of patients with inappropriate and appropriate shocks were calculated for shocks triggered at heart rates ≥ 170 bpm (ventricular tachycardia zone) and at rates ≥ 200 bpm (ventricular fibrillation zone). In the SC group, higher rates of patients with total and inappropriate shocks were delivered at heart rates ≥ 170 bpm than at rates ≥ 200 bpm (total shocks: 21.1% vs. 16.6%; p = 0.002; inappropriate shocks: 7.6% vs. 4.5%, p = 0.016; appropriate shocks: 15.2% vs. 13.5%; p = n.s.). No such differences were observed in the DC group (total shocks: 14.3% vs. 12.6%; p = n.s.; inappropriate shocks: 3.9% vs. 3.6%; p = n.s.; appropriate shocks: 12.2% vs. 10.4%; p = n.s.). The higher frequency of patients with total shocks with SC settings than with DC settings that benefit from PARAD+ was driven by a higher percentage of patients with inappropriate shocks in the VT zone (170-200 bpm) in the SC population.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier analysis of rates of freedom from inappropriate shocks in the total population when measured using cut-off limits of ≥170 bpm and ≥200 bpm, respectively.Note that the two curves represent the same population of patients and not two different treatment arms.
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f5: Kaplan-Meier analysis of rates of freedom from inappropriate shocks in the total population when measured using cut-off limits of ≥170 bpm and ≥200 bpm, respectively.Note that the two curves represent the same population of patients and not two different treatment arms.

Mentions: The Kaplan-Meier curves of inappropriate shocks over time using the ≥170 bpm and ≥200 bpm cut-off do not suggest clustering of shocks at specific times throughout the two years of follow-up (Fig. 5).


Relation between detection rate and inappropriate shocks in single versus dual chamber cardioverter-defibrillator--an analysis from the OPTION trial.

Kolb C, Sturmer M, Babuty D, Sick P, Davy JM, Molon G, Schwab JO, Mantovani G, Wickliffe A, Lennerz C, Semmler V, Siot PH, Reif S - Sci Rep (2016)

Kaplan-Meier analysis of rates of freedom from inappropriate shocks in the total population when measured using cut-off limits of ≥170 bpm and ≥200 bpm, respectively.Note that the two curves represent the same population of patients and not two different treatment arms.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4759595&req=5

f5: Kaplan-Meier analysis of rates of freedom from inappropriate shocks in the total population when measured using cut-off limits of ≥170 bpm and ≥200 bpm, respectively.Note that the two curves represent the same population of patients and not two different treatment arms.
Mentions: The Kaplan-Meier curves of inappropriate shocks over time using the ≥170 bpm and ≥200 bpm cut-off do not suggest clustering of shocks at specific times throughout the two years of follow-up (Fig. 5).

Bottom Line: The programming of implantable cardioverter-defibrillators (ICDs) influences inappropriate shock rates.In a post-hoc analysis, rates of patients with inappropriate and appropriate shocks were calculated for shocks triggered at heart rates ≥ 170 bpm (ventricular tachycardia zone) and at rates ≥ 200 bpm (ventricular fibrillation zone).The higher frequency of patients with total shocks with SC settings than with DC settings that benefit from PARAD+ was driven by a higher percentage of patients with inappropriate shocks in the VT zone (170-200 bpm) in the SC population.

View Article: PubMed Central - PubMed

Affiliation: Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Abteilung für Elektrophysiologie, Faculty of Medicine, Technische Universität München, Munich, Germany.

ABSTRACT
The programming of implantable cardioverter-defibrillators (ICDs) influences inappropriate shock rates. The aim of the study is to analyse rates of patients with appropriate and inappropriate shocks according to detection zones in the OPTION trial. All patients received dual chamber (DC) ICDs randomly assigned to be programmed either to single chamber (SC) or to DC settings including PARAD+ algorithm. In a post-hoc analysis, rates of patients with inappropriate and appropriate shocks were calculated for shocks triggered at heart rates ≥ 170 bpm (ventricular tachycardia zone) and at rates ≥ 200 bpm (ventricular fibrillation zone). In the SC group, higher rates of patients with total and inappropriate shocks were delivered at heart rates ≥ 170 bpm than at rates ≥ 200 bpm (total shocks: 21.1% vs. 16.6%; p = 0.002; inappropriate shocks: 7.6% vs. 4.5%, p = 0.016; appropriate shocks: 15.2% vs. 13.5%; p = n.s.). No such differences were observed in the DC group (total shocks: 14.3% vs. 12.6%; p = n.s.; inappropriate shocks: 3.9% vs. 3.6%; p = n.s.; appropriate shocks: 12.2% vs. 10.4%; p = n.s.). The higher frequency of patients with total shocks with SC settings than with DC settings that benefit from PARAD+ was driven by a higher percentage of patients with inappropriate shocks in the VT zone (170-200 bpm) in the SC population.

No MeSH data available.


Related in: MedlinePlus