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Cladosporium cladosporioides from the perspectives of medical and biotechnological approaches

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ABSTRACT

Fungi are important natural product sources that have enormous potential for the production of novel compounds for use in pharmacology, agricultural applications and industry. Compared with other natural sources such as plants, fungi are highly diverse but understudied. However, research on Cladosporium cladosporioides revealed the existence of bioactive products such as p-methylbenzoic acid, ergosterol peroxide (EP) and calphostin C as well as enzymes including pectin methylesterase (PME), polygalacturonase (PG) and chlorpyrifos hydrolase. p-Methylbenzoic acid has ability to synthesise 1,5-benzodiazepine and its derivatives, polyethylene terephthalate and eicosapentaenoic acid. EP has anticancer, antiangiogenic, antibacterial, anti-oxidative and immunosuppressive properties. Calphostin C inhibits protein kinase C (PKC) by inactivating both PKC-epsilon and PKC-alpha. In addition, calphostin C stimulates apoptosis in WEHI-231 cells and vascular smooth muscle cells. Based on the stimulation of endoplasmic reticulum stress in some types of cancer, calphostin C has also been evaluated as a potential photodynamic therapeutic agent. Methylesterase (PME) and PG have garnered attention because of their usage in the food processing industry and significant physiological function in plants. Chlorpyrifos, a human, animal and plant toxin, can be degraded and eliminated by chlorpyrifos hydrolase.

No MeSH data available.


Ergosterol peroxide (EP) structure
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Fig2: Ergosterol peroxide (EP) structure

Mentions: Ergosterol peroxide (EP) (Fig. 2), a bioactive compound, has been extracted from C. cladosporioides obtained from a marine sponge using spectroscopic methods (San-Martin et al. 2005). EP isolated from C. cladosporioides has not been examined against various types of diseases. However, EP isolated from different organisms ranging from fungi to plants has been reported to have anticancer, antiangiogenic, antibacterial, anti-oxidative and immunosuppressive properties (Rhee et al. 2012). EP, known as pro-vitamin D2, contributes to the prevention of colon and prostate cancer (Kobori et al. 2007). EP inhibits phorbol-12-myristate 13-acetate (TPA), TPA-induced inflammation and tumour promotion in mice (Kobori et al. 2007). EP also inhibits the growth of certain cancer cells, stimulates apoptosis in HL60 human leukaemia cells, reduces lipid peroxidation in rat liver microsomes and represses the production of mitogen stimulated mouse and human lymphocytes (Yasukawa et al. 1994; Fujimoto et al. 1994; Bok et al. 1999; Yaoita et al. 2002; Guyton et al. 2003; Kuo et al. 2003; Takei et al. 2005; Prompiboon et al. 2008).Fig. 2


Cladosporium cladosporioides from the perspectives of medical and biotechnological approaches
Ergosterol peroxide (EP) structure
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697913&req=5

Fig2: Ergosterol peroxide (EP) structure
Mentions: Ergosterol peroxide (EP) (Fig. 2), a bioactive compound, has been extracted from C. cladosporioides obtained from a marine sponge using spectroscopic methods (San-Martin et al. 2005). EP isolated from C. cladosporioides has not been examined against various types of diseases. However, EP isolated from different organisms ranging from fungi to plants has been reported to have anticancer, antiangiogenic, antibacterial, anti-oxidative and immunosuppressive properties (Rhee et al. 2012). EP, known as pro-vitamin D2, contributes to the prevention of colon and prostate cancer (Kobori et al. 2007). EP inhibits phorbol-12-myristate 13-acetate (TPA), TPA-induced inflammation and tumour promotion in mice (Kobori et al. 2007). EP also inhibits the growth of certain cancer cells, stimulates apoptosis in HL60 human leukaemia cells, reduces lipid peroxidation in rat liver microsomes and represses the production of mitogen stimulated mouse and human lymphocytes (Yasukawa et al. 1994; Fujimoto et al. 1994; Bok et al. 1999; Yaoita et al. 2002; Guyton et al. 2003; Kuo et al. 2003; Takei et al. 2005; Prompiboon et al. 2008).Fig. 2

View Article: PubMed Central - PubMed

ABSTRACT

Fungi are important natural product sources that have enormous potential for the production of novel compounds for use in pharmacology, agricultural applications and industry. Compared with other natural sources such as plants, fungi are highly diverse but understudied. However, research on Cladosporium cladosporioides revealed the existence of bioactive products such as p-methylbenzoic acid, ergosterol peroxide (EP) and calphostin C as well as enzymes including pectin methylesterase (PME), polygalacturonase (PG) and chlorpyrifos hydrolase. p-Methylbenzoic acid has ability to synthesise 1,5-benzodiazepine and its derivatives, polyethylene terephthalate and eicosapentaenoic acid. EP has anticancer, antiangiogenic, antibacterial, anti-oxidative and immunosuppressive properties. Calphostin C inhibits protein kinase C (PKC) by inactivating both PKC-epsilon and PKC-alpha. In addition, calphostin C stimulates apoptosis in WEHI-231 cells and vascular smooth muscle cells. Based on the stimulation of endoplasmic reticulum stress in some types of cancer, calphostin C has also been evaluated as a potential photodynamic therapeutic agent. Methylesterase (PME) and PG have garnered attention because of their usage in the food processing industry and significant physiological function in plants. Chlorpyrifos, a human, animal and plant toxin, can be degraded and eliminated by chlorpyrifos hydrolase.

No MeSH data available.