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Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats.

Kim K, Sung YH, Seo JH, Lee SW, Lim BV, Lee CY, Chung YR - J Exerc Rehabil (2015)

Bottom Line: In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats.The latency in the step-down avoidance task was deter-mined for the short-term memory.Western blot analysis was performed for the detection of BDNF and TrkB expression.

View Article: PubMed Central - PubMed

Affiliation: School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea.

ABSTRACT
Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moderate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity exercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2'-deoxyuridine was performed to determine hippocampal cell proliferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-exposed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.

No MeSH data available.


Related in: MedlinePlus

Effect of treadmill exercise on neurogenesis in the granular cell layer of the hippocampal dentate gyrus. (A) Control group, (B) mild-intensity exercise group, (C) moderate-intensity exercise group, (D) maternal lipopolysaccharide (LPS)-exposed group, (E) maternal LPS-exposed and mild-intensity exercise group, (F) maternal LPS-exposed and moderate-intensity exercise group. Data are presented as the mean±standard error of the mean. *P<0.05 compared to the control group. †P<0.05 compared to the maternal LPS-exposed group.
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f4-jer-11-6-296: Effect of treadmill exercise on neurogenesis in the granular cell layer of the hippocampal dentate gyrus. (A) Control group, (B) mild-intensity exercise group, (C) moderate-intensity exercise group, (D) maternal lipopolysaccharide (LPS)-exposed group, (E) maternal LPS-exposed and mild-intensity exercise group, (F) maternal LPS-exposed and moderate-intensity exercise group. Data are presented as the mean±standard error of the mean. *P<0.05 compared to the control group. †P<0.05 compared to the maternal LPS-exposed group.

Mentions: Neurogenesis in the granular cell layer of the hippocampal dentate gyrus was decreased in the rats born of the LPS-exposed maternal rats. Treadmill exercise at mild-intensity and moderate-intensity enhanced neurogenesis in the granular cell layer of the hippocampal dentate gyrus in the rats born of the LPS-exposed maternal rats. Treadmill exercise at mild-intensity and moderate-intensity enhanced neurogenesis in the granular cell layer of the hippocampal dentate gyrus in the rats born of the normal maternal rats (Fig. 4).


Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats.

Kim K, Sung YH, Seo JH, Lee SW, Lim BV, Lee CY, Chung YR - J Exerc Rehabil (2015)

Effect of treadmill exercise on neurogenesis in the granular cell layer of the hippocampal dentate gyrus. (A) Control group, (B) mild-intensity exercise group, (C) moderate-intensity exercise group, (D) maternal lipopolysaccharide (LPS)-exposed group, (E) maternal LPS-exposed and mild-intensity exercise group, (F) maternal LPS-exposed and moderate-intensity exercise group. Data are presented as the mean±standard error of the mean. *P<0.05 compared to the control group. †P<0.05 compared to the maternal LPS-exposed group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697777&req=5

f4-jer-11-6-296: Effect of treadmill exercise on neurogenesis in the granular cell layer of the hippocampal dentate gyrus. (A) Control group, (B) mild-intensity exercise group, (C) moderate-intensity exercise group, (D) maternal lipopolysaccharide (LPS)-exposed group, (E) maternal LPS-exposed and mild-intensity exercise group, (F) maternal LPS-exposed and moderate-intensity exercise group. Data are presented as the mean±standard error of the mean. *P<0.05 compared to the control group. †P<0.05 compared to the maternal LPS-exposed group.
Mentions: Neurogenesis in the granular cell layer of the hippocampal dentate gyrus was decreased in the rats born of the LPS-exposed maternal rats. Treadmill exercise at mild-intensity and moderate-intensity enhanced neurogenesis in the granular cell layer of the hippocampal dentate gyrus in the rats born of the LPS-exposed maternal rats. Treadmill exercise at mild-intensity and moderate-intensity enhanced neurogenesis in the granular cell layer of the hippocampal dentate gyrus in the rats born of the normal maternal rats (Fig. 4).

Bottom Line: In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats.The latency in the step-down avoidance task was deter-mined for the short-term memory.Western blot analysis was performed for the detection of BDNF and TrkB expression.

View Article: PubMed Central - PubMed

Affiliation: School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea.

ABSTRACT
Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moderate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity exercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2'-deoxyuridine was performed to determine hippocampal cell proliferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-exposed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.

No MeSH data available.


Related in: MedlinePlus