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Mentions: High-gamma activity (HGA) at frequencies 60-200 Hz have been observed during task-related cortical activation in humans  and in animals , and have been used to map normal brain function and to decode commands in brain-computer interfaces. To understand the role that HGA plays in both normal and pathological brain states, deeper insights into its generating mechanisms are essential. Because the neural populations recorded by LFPs and EEG cannot be comprehensively recorded at scales that are likely to be relevant, we used a biologically based computational model of a cortical network to investigate the mechanisms generating HGA. The computational model included excitatory pyramidal regular-spiking and inhibitory fast-spiking neurons described by Hodgkin - Huxley dynamics. We compared activity generated by this model with HGA that was observed in LFP recorded in monkey somatosensory cortex during vibrotactile stimulation. Increase of firing rate and broadband HGA responses in LFP signals generated by the model were in agreement with experimental results (see Figure 1).
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