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Scoping review to identify potential non-antimicrobial interventions to mitigate antimicrobial resistance in commensal enteric bacteria in North American cattle production systems.

Murphy CP, Fajt VR, Scott HM, Foster MJ, Wickwire P, McEwen SA - Epidemiol. Infect. (2015)

Bottom Line: Citations were retained when modifiable non-antimicrobial factors or interventions potentially associated with antimicrobial resistance were described.Most reported associations between the non-antimicrobial modifiable factors or interventions and antimicrobial resistance were not statistically significant (P > 0·05 and a confidence interval including 1), but when significant, the results were not consistent in direction (increase or decrease in antimicrobial resistance) or magnitude.Research is needed to better understand the impacts of promising modifiable factors or interventions on the occurrence of antimicrobial resistance before any recommendations can be offered or adopted.

View Article: PubMed Central - PubMed

Affiliation: Population Medicine,University of Guelph,Guelph,Ontario,Canada.

ABSTRACT
A scoping review was conducted to identify modifiable non-antimicrobial factors to reduce the occurrence of antimicrobial resistance in cattle populations. Searches were developed to retrieve peer-reviewed published studies in animal, human and in vitro microbial populations. Citations were retained when modifiable non-antimicrobial factors or interventions potentially associated with antimicrobial resistance were described. Studies described resistance in five bacterial genera, species or types, and 40 antimicrobials. Modifiable non-antimicrobial factors or interventions ranged widely in type, and the depth of evidence in animal populations was shallow. Specific associations between a factor or intervention with antimicrobial resistance in a population (e.g. associations between organic systems and tetracycline susceptibility in E. coli from cattle) were reported in a maximum of three studies. The identified non-antimicrobial factors or interventions were classified into 16 themes. Most reported associations between the non-antimicrobial modifiable factors or interventions and antimicrobial resistance were not statistically significant (P > 0·05 and a confidence interval including 1), but when significant, the results were not consistent in direction (increase or decrease in antimicrobial resistance) or magnitude. Research is needed to better understand the impacts of promising modifiable factors or interventions on the occurrence of antimicrobial resistance before any recommendations can be offered or adopted.

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Distribution of study design from retained citations studying non-antimicrobialfactors associated with antimicrobial resistance in animal populations.
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fig03: Distribution of study design from retained citations studying non-antimicrobialfactors associated with antimicrobial resistance in animal populations.

Mentions: Of the 27 060 de-duplicated citations, 506 reported on modifiable non-antimicrobial factorsor interventions. Most of these described studies in human populations exclusively(n = 356, 70%), 16% (n = 82) involved animalpopulations, and 13% (n = 68) were conducted entirely invitro (Fig. 1). Of the retained citationsinvolving human and animal populations, the most common study type was observational(n = 366, 93%) (Figs 2 and 3). Fig. 2.


Scoping review to identify potential non-antimicrobial interventions to mitigate antimicrobial resistance in commensal enteric bacteria in North American cattle production systems.

Murphy CP, Fajt VR, Scott HM, Foster MJ, Wickwire P, McEwen SA - Epidemiol. Infect. (2015)

Distribution of study design from retained citations studying non-antimicrobialfactors associated with antimicrobial resistance in animal populations.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697299&req=5

fig03: Distribution of study design from retained citations studying non-antimicrobialfactors associated with antimicrobial resistance in animal populations.
Mentions: Of the 27 060 de-duplicated citations, 506 reported on modifiable non-antimicrobial factorsor interventions. Most of these described studies in human populations exclusively(n = 356, 70%), 16% (n = 82) involved animalpopulations, and 13% (n = 68) were conducted entirely invitro (Fig. 1). Of the retained citationsinvolving human and animal populations, the most common study type was observational(n = 366, 93%) (Figs 2 and 3). Fig. 2.

Bottom Line: Citations were retained when modifiable non-antimicrobial factors or interventions potentially associated with antimicrobial resistance were described.Most reported associations between the non-antimicrobial modifiable factors or interventions and antimicrobial resistance were not statistically significant (P > 0·05 and a confidence interval including 1), but when significant, the results were not consistent in direction (increase or decrease in antimicrobial resistance) or magnitude.Research is needed to better understand the impacts of promising modifiable factors or interventions on the occurrence of antimicrobial resistance before any recommendations can be offered or adopted.

View Article: PubMed Central - PubMed

Affiliation: Population Medicine,University of Guelph,Guelph,Ontario,Canada.

ABSTRACT
A scoping review was conducted to identify modifiable non-antimicrobial factors to reduce the occurrence of antimicrobial resistance in cattle populations. Searches were developed to retrieve peer-reviewed published studies in animal, human and in vitro microbial populations. Citations were retained when modifiable non-antimicrobial factors or interventions potentially associated with antimicrobial resistance were described. Studies described resistance in five bacterial genera, species or types, and 40 antimicrobials. Modifiable non-antimicrobial factors or interventions ranged widely in type, and the depth of evidence in animal populations was shallow. Specific associations between a factor or intervention with antimicrobial resistance in a population (e.g. associations between organic systems and tetracycline susceptibility in E. coli from cattle) were reported in a maximum of three studies. The identified non-antimicrobial factors or interventions were classified into 16 themes. Most reported associations between the non-antimicrobial modifiable factors or interventions and antimicrobial resistance were not statistically significant (P > 0·05 and a confidence interval including 1), but when significant, the results were not consistent in direction (increase or decrease in antimicrobial resistance) or magnitude. Research is needed to better understand the impacts of promising modifiable factors or interventions on the occurrence of antimicrobial resistance before any recommendations can be offered or adopted.

Show MeSH