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Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: a randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study).

Putet G, Labaune JM, Mace K, Steenhout P, Grathwohl D, Raverot V, Morel Y, Picaud JC - Br. J. Nutr. (2015)

Bottom Line: During the first 60 months of life, anthropometric parameters in the F1·8 group were lower compared with the F2·7 group, and the differences were significant for head circumference from 2 to 60 months, body weight at 4 and 6 months and length at 9, 12 and 36 months of age.There were no significant differences in body composition between these two groups at any age.We conclude that, in formula-fed infants, although increased protein intake did not affect the IGF-1 concentration during the first 12 months of life, it did affect length and head circumference growth, suggesting that factors other than IGF-1 could play roles in determining growth velocity.

View Article: PubMed Central - PubMed

Affiliation: 1Service de Neonatologie,Hopital de la Croix-Rousse,Hospices Civils de Lyon,F-69004 Lyon,France.

ABSTRACT
The effect of protein intake on growth velocity in infancy may be mediated by insulin-like growth factor-1 (IGF-1). This study aimed to determine the effects of formulae containing 1·8 (F1·8) or 2·7 g (F2·7) protein/418·4 kJ (100 kcal) on IGF-1 concentrations and growth. Healthy term infants were randomly assigned to receive F1·8 (n 74) or F2·7 (n 80) exclusively for the first 4 months of life. A group of breast-fed infants (n 84) was followed-up simultaneously (reference). Growth and body composition were measured at 0·5, 4, 6, 12, 36, 48 and 60 months of life. The IGF-1 concentrations at 4 months (primary outcome) were similar in the F1·8 (67·1 (sd 20·8) ng/l; n 70) and F2·7 (71·2 (sd 27·5) ng/l; n 73) groups (P=0·52). Both formula groups had higher IGF-1 concentrations than the breast-fed group at 4 and 9 months of age (P≤0·0001). During the first 60 months of life, anthropometric parameters in the F1·8 group were lower compared with the F2·7 group, and the differences were significant for head circumference from 2 to 60 months, body weight at 4 and 6 months and length at 9, 12 and 36 months of age. There were no significant differences in body composition between these two groups at any age. We conclude that, in formula-fed infants, although increased protein intake did not affect the IGF-1 concentration during the first 12 months of life, it did affect length and head circumference growth, suggesting that factors other than IGF-1 could play roles in determining growth velocity.

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Infants’ participation throughout the randomised, double-blind study of infantformula. F1·8, low-protein formula (1·8 g/418·4 kJ (100 kcal)); F2·7,standard-protein formula (2·7 g/418·4 kJ (100 kcal)); IGF-1, insulin-like growthfactor-1.
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fig1: Infants’ participation throughout the randomised, double-blind study of infantformula. F1·8, low-protein formula (1·8 g/418·4 kJ (100 kcal)); F2·7,standard-protein formula (2·7 g/418·4 kJ (100 kcal)); IGF-1, insulin-like growthfactor-1.

Mentions: Between June 2006 and October 2007, 238 infants were enrolled in the EPOCH study and wereincluded in the ITT analysis set (n 74 in the F1·8 group,n 80 in the F2·7 group and n 84 in the breast-fed group)(Fig. 1). Data from thirty infants were excludedfrom the ITT analysis, owing to dropout from the study or difficulty obtaining IGF-1measurements at 4 months of age (Fig. 1); none ofthese infants had IGF-1 measurements. Thus, the results of the primary outcome from the PPanalysis were similar to that of the ITT analysis, and only the ITT analyses are presentedin this report.Fig. 1


Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: a randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study).

Putet G, Labaune JM, Mace K, Steenhout P, Grathwohl D, Raverot V, Morel Y, Picaud JC - Br. J. Nutr. (2015)

Infants’ participation throughout the randomised, double-blind study of infantformula. F1·8, low-protein formula (1·8 g/418·4 kJ (100 kcal)); F2·7,standard-protein formula (2·7 g/418·4 kJ (100 kcal)); IGF-1, insulin-like growthfactor-1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697297&req=5

fig1: Infants’ participation throughout the randomised, double-blind study of infantformula. F1·8, low-protein formula (1·8 g/418·4 kJ (100 kcal)); F2·7,standard-protein formula (2·7 g/418·4 kJ (100 kcal)); IGF-1, insulin-like growthfactor-1.
Mentions: Between June 2006 and October 2007, 238 infants were enrolled in the EPOCH study and wereincluded in the ITT analysis set (n 74 in the F1·8 group,n 80 in the F2·7 group and n 84 in the breast-fed group)(Fig. 1). Data from thirty infants were excludedfrom the ITT analysis, owing to dropout from the study or difficulty obtaining IGF-1measurements at 4 months of age (Fig. 1); none ofthese infants had IGF-1 measurements. Thus, the results of the primary outcome from the PPanalysis were similar to that of the ITT analysis, and only the ITT analyses are presentedin this report.Fig. 1

Bottom Line: During the first 60 months of life, anthropometric parameters in the F1·8 group were lower compared with the F2·7 group, and the differences were significant for head circumference from 2 to 60 months, body weight at 4 and 6 months and length at 9, 12 and 36 months of age.There were no significant differences in body composition between these two groups at any age.We conclude that, in formula-fed infants, although increased protein intake did not affect the IGF-1 concentration during the first 12 months of life, it did affect length and head circumference growth, suggesting that factors other than IGF-1 could play roles in determining growth velocity.

View Article: PubMed Central - PubMed

Affiliation: 1Service de Neonatologie,Hopital de la Croix-Rousse,Hospices Civils de Lyon,F-69004 Lyon,France.

ABSTRACT
The effect of protein intake on growth velocity in infancy may be mediated by insulin-like growth factor-1 (IGF-1). This study aimed to determine the effects of formulae containing 1·8 (F1·8) or 2·7 g (F2·7) protein/418·4 kJ (100 kcal) on IGF-1 concentrations and growth. Healthy term infants were randomly assigned to receive F1·8 (n 74) or F2·7 (n 80) exclusively for the first 4 months of life. A group of breast-fed infants (n 84) was followed-up simultaneously (reference). Growth and body composition were measured at 0·5, 4, 6, 12, 36, 48 and 60 months of life. The IGF-1 concentrations at 4 months (primary outcome) were similar in the F1·8 (67·1 (sd 20·8) ng/l; n 70) and F2·7 (71·2 (sd 27·5) ng/l; n 73) groups (P=0·52). Both formula groups had higher IGF-1 concentrations than the breast-fed group at 4 and 9 months of age (P≤0·0001). During the first 60 months of life, anthropometric parameters in the F1·8 group were lower compared with the F2·7 group, and the differences were significant for head circumference from 2 to 60 months, body weight at 4 and 6 months and length at 9, 12 and 36 months of age. There were no significant differences in body composition between these two groups at any age. We conclude that, in formula-fed infants, although increased protein intake did not affect the IGF-1 concentration during the first 12 months of life, it did affect length and head circumference growth, suggesting that factors other than IGF-1 could play roles in determining growth velocity.

Show MeSH
Related in: MedlinePlus