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Dipstick urinalysis findings in children with Plasmodium falciparum in the South Tongu District: A case-control study.

Ephraim RK, Tashie W, Agbodzakey H, Sakyi SA, Essien-Baidoo S, Adoba P, Adu P, Ampong J - Niger Med J (2015 Jul-Aug)

Bottom Line: A pretested questionnaire was used to obtain demographic and clinical data.Urine protein (P < 0.001), blood (P < 0.001), bilirubin (P < 0.001), urobilinogen (P < 0.001), and ketones (P = 0.001) were significantly higher in individuals with P. falciparum infection than in healthy controls.Dipstick urinalysis can be used together with light microscopy in resource-limited malaria-endemic areas to accurately diagnose falciparum malaria infection.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Technology, University of Cape Coast, Cape Coast, Ghana.

ABSTRACT

Background: Malaria ranks among the major health and developmental challenges facing some of the poorest countries in tropical and sub-tropical regions across the globe. We determined urinary abnormalities and its relationship with parasite density in children ≤12 years with Plasmodium falciparum infection.

Materials and methods: From December 2013 to March 2014, we randomly recruited 116 participants comprising 58 malaria patients (cases) and 58 healthy controls from the Comboni Mission and the Sogakope District Hospitals both in the South Tongu district. Blood was collected for the estimation of hemoglobin and total white blood cells; thick and thin blood films were used for the determination of malaria parasite density. Urine was collected for the measurement of the various biochemical components using the automated urine analyzer. A pretested questionnaire was used to obtain demographic and clinical data.

Results: Urine protein (P < 0.001), blood (P < 0.001), bilirubin (P < 0.001), urobilinogen (P < 0.001), and ketones (P = 0.001) were significantly higher in individuals with P. falciparum infection than in healthy controls. Proteinuria (P = 0.247; r = 0.155), hematuria (P = 0.142; r = 0.195), bilirubinuria (P = 0.001; r = 0.438), urobilinogenuria (P = 0.876; r = 0.021), and ketonuria (P = 0.136; r = 0.198) were positively correlated with malaria parasite density; however, only bilirubinuria was significantly higher at higher parasitemia.

Conclusion: Malaria has a significant effect on the chemical composition of urine with bilirubin positively correlated with parasite density. Dipstick urinalysis can be used together with light microscopy in resource-limited malaria-endemic areas to accurately diagnose falciparum malaria infection.

No MeSH data available.


Related in: MedlinePlus

Differences between the significant urinary abnormalities of the cases and controls
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Figure 1: Differences between the significant urinary abnormalities of the cases and controls

Mentions: Figure 1 is a graphical (visual) presentation of the comparison of the significant dipstick urinalysis findings between cases and controls.


Dipstick urinalysis findings in children with Plasmodium falciparum in the South Tongu District: A case-control study.

Ephraim RK, Tashie W, Agbodzakey H, Sakyi SA, Essien-Baidoo S, Adoba P, Adu P, Ampong J - Niger Med J (2015 Jul-Aug)

Differences between the significant urinary abnormalities of the cases and controls
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697220&req=5

Figure 1: Differences between the significant urinary abnormalities of the cases and controls
Mentions: Figure 1 is a graphical (visual) presentation of the comparison of the significant dipstick urinalysis findings between cases and controls.

Bottom Line: A pretested questionnaire was used to obtain demographic and clinical data.Urine protein (P < 0.001), blood (P < 0.001), bilirubin (P < 0.001), urobilinogen (P < 0.001), and ketones (P = 0.001) were significantly higher in individuals with P. falciparum infection than in healthy controls.Dipstick urinalysis can be used together with light microscopy in resource-limited malaria-endemic areas to accurately diagnose falciparum malaria infection.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Technology, University of Cape Coast, Cape Coast, Ghana.

ABSTRACT

Background: Malaria ranks among the major health and developmental challenges facing some of the poorest countries in tropical and sub-tropical regions across the globe. We determined urinary abnormalities and its relationship with parasite density in children ≤12 years with Plasmodium falciparum infection.

Materials and methods: From December 2013 to March 2014, we randomly recruited 116 participants comprising 58 malaria patients (cases) and 58 healthy controls from the Comboni Mission and the Sogakope District Hospitals both in the South Tongu district. Blood was collected for the estimation of hemoglobin and total white blood cells; thick and thin blood films were used for the determination of malaria parasite density. Urine was collected for the measurement of the various biochemical components using the automated urine analyzer. A pretested questionnaire was used to obtain demographic and clinical data.

Results: Urine protein (P < 0.001), blood (P < 0.001), bilirubin (P < 0.001), urobilinogen (P < 0.001), and ketones (P = 0.001) were significantly higher in individuals with P. falciparum infection than in healthy controls. Proteinuria (P = 0.247; r = 0.155), hematuria (P = 0.142; r = 0.195), bilirubinuria (P = 0.001; r = 0.438), urobilinogenuria (P = 0.876; r = 0.021), and ketonuria (P = 0.136; r = 0.198) were positively correlated with malaria parasite density; however, only bilirubinuria was significantly higher at higher parasitemia.

Conclusion: Malaria has a significant effect on the chemical composition of urine with bilirubin positively correlated with parasite density. Dipstick urinalysis can be used together with light microscopy in resource-limited malaria-endemic areas to accurately diagnose falciparum malaria infection.

No MeSH data available.


Related in: MedlinePlus