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Pulmonary and extra-pulmonary manifestations of sarcoidosis.

Tavana S, Alizadeh M, Mohajerani SA, Hashemian SM - Niger Med J (2015 Jul-Aug)

Bottom Line: Pulmonary involvements are both fibrosis and granulomatosis and the most common manifestations are parenchymal nodules, bronchiectasia and high-grade fibrosis.The most common extra-pulmonary involvement is arthritis.Lab tests are non-specific and have no correlation with duration or severity of disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Clinical Research and Development Center, Shahid Modarres Hospital, Tehran, Iran.

ABSTRACT

Background: Sarcoidosis is a systemic multi-organ granulomatous disease of unknown etiology that is characterized by the presence of granuloma in various organs. The clinical features of sarcoidosis are heterogeneous but pulmonary involvement is cardinal manifestations. The aim of this study was to determine radiologic, clinical and laboratory findings of patients with sarcoidosis.

Patients and methods: In a cross-sectional study, all patients visiting sarcoidosis clinic were enrolled in the study. Computed tomography (CT) scan was obtained and lab exams were obtained from patient and reports were recorded in data sheet.

Results: Total of 55 patients with sarcoidosis were enrolled in the study. The average of age was 44.6 (range 25-62) years. Thirty-seven patients were male and 18 were female. The most common extra-pulmonary manifestation was arthritis (in 18% of cases) and then lupus pernio (12.8%) and uveitis (10.9%). Bilateral hilar adenopathy and para tracheal lymphadenopathy was observed in 39(70%) and 22 (40%) of patients. Parenchymal nodules (30%), bronchiectasia (25%), ground-glass opacification (18%) were the most common findings. Percentages of patients with dyspnea were 29% and percentages of patients with cough were 21%. Among abnormal lab tests, high urine calcium (Ca) were positive in 21% and high angiotensin-converting enzyme (ACE) in 16% of patients.

Conclusion: Pulmonary involvements are both fibrosis and granulomatosis and the most common manifestations are parenchymal nodules, bronchiectasia and high-grade fibrosis. The most common extra-pulmonary involvement is arthritis. Lab tests are non-specific and have no correlation with duration or severity of disease.

No MeSH data available.


Related in: MedlinePlus

Percentage of patients with arthritis, uveitis, and Erythema Nodosum (EN) classified based on their stage.
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Figure 1: Percentage of patients with arthritis, uveitis, and Erythema Nodosum (EN) classified based on their stage.

Mentions: Interestingly, when patients with arthritis, uveitis, erythem nodosum (EN) were classified based on their stage of the disease. Higher percentage of patient in stage 1 had arthritis than uveitis and EN, while in stage 4 more patients had EN [Figure 1].


Pulmonary and extra-pulmonary manifestations of sarcoidosis.

Tavana S, Alizadeh M, Mohajerani SA, Hashemian SM - Niger Med J (2015 Jul-Aug)

Percentage of patients with arthritis, uveitis, and Erythema Nodosum (EN) classified based on their stage.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697213&req=5

Figure 1: Percentage of patients with arthritis, uveitis, and Erythema Nodosum (EN) classified based on their stage.
Mentions: Interestingly, when patients with arthritis, uveitis, erythem nodosum (EN) were classified based on their stage of the disease. Higher percentage of patient in stage 1 had arthritis than uveitis and EN, while in stage 4 more patients had EN [Figure 1].

Bottom Line: Pulmonary involvements are both fibrosis and granulomatosis and the most common manifestations are parenchymal nodules, bronchiectasia and high-grade fibrosis.The most common extra-pulmonary involvement is arthritis.Lab tests are non-specific and have no correlation with duration or severity of disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Clinical Research and Development Center, Shahid Modarres Hospital, Tehran, Iran.

ABSTRACT

Background: Sarcoidosis is a systemic multi-organ granulomatous disease of unknown etiology that is characterized by the presence of granuloma in various organs. The clinical features of sarcoidosis are heterogeneous but pulmonary involvement is cardinal manifestations. The aim of this study was to determine radiologic, clinical and laboratory findings of patients with sarcoidosis.

Patients and methods: In a cross-sectional study, all patients visiting sarcoidosis clinic were enrolled in the study. Computed tomography (CT) scan was obtained and lab exams were obtained from patient and reports were recorded in data sheet.

Results: Total of 55 patients with sarcoidosis were enrolled in the study. The average of age was 44.6 (range 25-62) years. Thirty-seven patients were male and 18 were female. The most common extra-pulmonary manifestation was arthritis (in 18% of cases) and then lupus pernio (12.8%) and uveitis (10.9%). Bilateral hilar adenopathy and para tracheal lymphadenopathy was observed in 39(70%) and 22 (40%) of patients. Parenchymal nodules (30%), bronchiectasia (25%), ground-glass opacification (18%) were the most common findings. Percentages of patients with dyspnea were 29% and percentages of patients with cough were 21%. Among abnormal lab tests, high urine calcium (Ca) were positive in 21% and high angiotensin-converting enzyme (ACE) in 16% of patients.

Conclusion: Pulmonary involvements are both fibrosis and granulomatosis and the most common manifestations are parenchymal nodules, bronchiectasia and high-grade fibrosis. The most common extra-pulmonary involvement is arthritis. Lab tests are non-specific and have no correlation with duration or severity of disease.

No MeSH data available.


Related in: MedlinePlus