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Recent Advances in Electrochemical Biosensors Based on Fullerene-C60 Nano-Structured Platforms.

Pilehvar S, De Wael K - Biosensors (Basel) (2015)

Bottom Line: The performance and sensitivity of biosensors is greatly improved with the integration of nanomaterials into their construction.Since its first discovery, fullerene-C60 has been the object of extensive research.We examine the research work reported in the literature on the synthesis, functionalization, approaches to nanostructuring electrodes with fullerene, and outline some of the exciting applications in the field of (bio)sensing.

View Article: PubMed Central - PubMed

Affiliation: AXES Research Group, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. Sanaz.pilehvar@uantwerpen.be.

ABSTRACT
Nanotechnology is becoming increasingly important in the field of (bio)sensors. The performance and sensitivity of biosensors is greatly improved with the integration of nanomaterials into their construction. Since its first discovery, fullerene-C60 has been the object of extensive research. Its unique and favorable characteristics of easy chemical modification, conductivity, and electrochemical properties has led to its tremendous use in (bio)sensor applications. This paper provides a concise review of advances in fullerene-C60 research and its use as a nanomaterial for the development of biosensors. We examine the research work reported in the literature on the synthesis, functionalization, approaches to nanostructuring electrodes with fullerene, and outline some of the exciting applications in the field of (bio)sensing.

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(a) Schematic illustration of the stepwise aptasensor fabrication process and the dual signal amplification mechanism, adapted from [64]; (b) schematic diagram of fabrication and detection of the ECL aptasensor, adapted from [65]; and (c) results of molecular modeling related to (A) groove binding of small molecules to the minor groove of dsDNA and (B) groove binding of fullerene-C60 to the major groove of dsDNA, adapted from [66].
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biosensors-05-00712-f004: (a) Schematic illustration of the stepwise aptasensor fabrication process and the dual signal amplification mechanism, adapted from [64]; (b) schematic diagram of fabrication and detection of the ECL aptasensor, adapted from [65]; and (c) results of molecular modeling related to (A) groove binding of small molecules to the minor groove of dsDNA and (B) groove binding of fullerene-C60 to the major groove of dsDNA, adapted from [66].


Recent Advances in Electrochemical Biosensors Based on Fullerene-C60 Nano-Structured Platforms.

Pilehvar S, De Wael K - Biosensors (Basel) (2015)

(a) Schematic illustration of the stepwise aptasensor fabrication process and the dual signal amplification mechanism, adapted from [64]; (b) schematic diagram of fabrication and detection of the ECL aptasensor, adapted from [65]; and (c) results of molecular modeling related to (A) groove binding of small molecules to the minor groove of dsDNA and (B) groove binding of fullerene-C60 to the major groove of dsDNA, adapted from [66].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697141&req=5

biosensors-05-00712-f004: (a) Schematic illustration of the stepwise aptasensor fabrication process and the dual signal amplification mechanism, adapted from [64]; (b) schematic diagram of fabrication and detection of the ECL aptasensor, adapted from [65]; and (c) results of molecular modeling related to (A) groove binding of small molecules to the minor groove of dsDNA and (B) groove binding of fullerene-C60 to the major groove of dsDNA, adapted from [66].
Bottom Line: The performance and sensitivity of biosensors is greatly improved with the integration of nanomaterials into their construction.Since its first discovery, fullerene-C60 has been the object of extensive research.We examine the research work reported in the literature on the synthesis, functionalization, approaches to nanostructuring electrodes with fullerene, and outline some of the exciting applications in the field of (bio)sensing.

View Article: PubMed Central - PubMed

Affiliation: AXES Research Group, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. Sanaz.pilehvar@uantwerpen.be.

ABSTRACT
Nanotechnology is becoming increasingly important in the field of (bio)sensors. The performance and sensitivity of biosensors is greatly improved with the integration of nanomaterials into their construction. Since its first discovery, fullerene-C60 has been the object of extensive research. Its unique and favorable characteristics of easy chemical modification, conductivity, and electrochemical properties has led to its tremendous use in (bio)sensor applications. This paper provides a concise review of advances in fullerene-C60 research and its use as a nanomaterial for the development of biosensors. We examine the research work reported in the literature on the synthesis, functionalization, approaches to nanostructuring electrodes with fullerene, and outline some of the exciting applications in the field of (bio)sensing.

Show MeSH
Related in: MedlinePlus