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Quantification of experimental venous thrombus resolution by longitudinal nanogold-enhanced micro-computed tomography.

Grover SP, Saha P, Jenkins J, Mukkavilli A, Lyons OT, Patel AS, Sunassee K, Modarai B, Smith A - Thromb. Res. (2015)

Bottom Line: This cross-sectional design imposes the need for increased numbers of animals for experiments.Intra- and inter-observer analyses were highly correlated (ICC=0.99 and 0.91 respectively, P<0.0001).Further histological analysis revealed noticeable levels of contrast agent extravasation into the thrombus that was associated with the presence of neovascular channels, macrophages and intracellular iron deposits.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at King's Health Partners, St Thomas' Hospital, London, UK.

No MeSH data available.


Related in: MedlinePlus

Imaging of IVC thrombi by contrast-enhanced microCT.A representative day 1 thrombus imaged by contrast-enhanced microCT shown in transverse (A), sagittal (B) and coronal (C) planes (scale bar 2 mm). Segmentation of the scan allow for reconstruction of 3D volume renders (D–F). Images have been annotated with the position of the aorta (Ao), the site of stenosis (S) and the thrombus (T).
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f0005: Imaging of IVC thrombi by contrast-enhanced microCT.A representative day 1 thrombus imaged by contrast-enhanced microCT shown in transverse (A), sagittal (B) and coronal (C) planes (scale bar 2 mm). Segmentation of the scan allow for reconstruction of 3D volume renders (D–F). Images have been annotated with the position of the aorta (Ao), the site of stenosis (S) and the thrombus (T).

Mentions: IVC resident thrombus was visualised in situ by contrast-enhanced microCT. Thrombus presented as a hypo-perfused region distal to the site of stenosis (Fig. 1A–C). The presence of a perfusion defect in the IVC lumen enabled segmentation of the thrombus from surrounding tissue and subsequent reconstruction of 3D volume renders of the thrombus and surrounding vascular features (Fig. 1D–F).


Quantification of experimental venous thrombus resolution by longitudinal nanogold-enhanced micro-computed tomography.

Grover SP, Saha P, Jenkins J, Mukkavilli A, Lyons OT, Patel AS, Sunassee K, Modarai B, Smith A - Thromb. Res. (2015)

Imaging of IVC thrombi by contrast-enhanced microCT.A representative day 1 thrombus imaged by contrast-enhanced microCT shown in transverse (A), sagittal (B) and coronal (C) planes (scale bar 2 mm). Segmentation of the scan allow for reconstruction of 3D volume renders (D–F). Images have been annotated with the position of the aorta (Ao), the site of stenosis (S) and the thrombus (T).
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697135&req=5

f0005: Imaging of IVC thrombi by contrast-enhanced microCT.A representative day 1 thrombus imaged by contrast-enhanced microCT shown in transverse (A), sagittal (B) and coronal (C) planes (scale bar 2 mm). Segmentation of the scan allow for reconstruction of 3D volume renders (D–F). Images have been annotated with the position of the aorta (Ao), the site of stenosis (S) and the thrombus (T).
Mentions: IVC resident thrombus was visualised in situ by contrast-enhanced microCT. Thrombus presented as a hypo-perfused region distal to the site of stenosis (Fig. 1A–C). The presence of a perfusion defect in the IVC lumen enabled segmentation of the thrombus from surrounding tissue and subsequent reconstruction of 3D volume renders of the thrombus and surrounding vascular features (Fig. 1D–F).

Bottom Line: This cross-sectional design imposes the need for increased numbers of animals for experiments.Intra- and inter-observer analyses were highly correlated (ICC=0.99 and 0.91 respectively, P<0.0001).Further histological analysis revealed noticeable levels of contrast agent extravasation into the thrombus that was associated with the presence of neovascular channels, macrophages and intracellular iron deposits.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at King's Health Partners, St Thomas' Hospital, London, UK.

No MeSH data available.


Related in: MedlinePlus