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Brain-derived neurotrophic factor and its clinical implications.

Bathina S, Das UN - Arch Med Sci (2015)

Bottom Line: It is widely expressed in the CNS, gut and other tissues.BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival.Thus, BDNF may be useful in the prevention and management of several diseases including diabetes mellitus.

View Article: PubMed Central - PubMed

Affiliation: Bio-Science Research Center, Gayatri Vidya Parishad College of Engineering, Visakhapatnam, India.

ABSTRACT
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues. BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival. BDNF and insulin-like growth factor-1 have similar downstream signaling mechanisms incorporating both p-CAMK and MAPK that increase the expression of pro-survival genes. Brain-derived neurotrophic factor regulates glucose and energy metabolism and prevents exhaustion of β cells. Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Thus, BDNF may be useful in the prevention and management of several diseases including diabetes mellitus.

No MeSH data available.


Related in: MedlinePlus

The above figure illustrates the fact of origin of pro-BDNF in endoplasmic reticulum (ER), which is later transported to the Golgi complex (GC) and then to the trans-Golgi network (TGN). From here in the regulated pathway, by the action of CPE and convertase, 13 KDa mature BDNF (mBDNF) is formed and released outside the plasma membrane. This figure is adapted from ref. [13]
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Figure 0001: The above figure illustrates the fact of origin of pro-BDNF in endoplasmic reticulum (ER), which is later transported to the Golgi complex (GC) and then to the trans-Golgi network (TGN). From here in the regulated pathway, by the action of CPE and convertase, 13 KDa mature BDNF (mBDNF) is formed and released outside the plasma membrane. This figure is adapted from ref. [13]

Mentions: BDNF is a member of the neurotrophin family of growth factors along with nerve growth factor (NGF); neurotrophins-3 (NT-3), NT4/5 and NT-6. BDNF is synthesized in the endoplasmic reticulum (ER) as a 32–35 kDa precursor protein (pro BDNF) that moves through the Golgi apparatus and trans-Golgi network (TGN). In the presence of lipid raft associated sorting receptor carboxy peptidase E (CPE), pro-BDNF is sorted by vesicles and subsequently transported into activity-dependent secretion by post-synaptic dendrites (Figure 1). The terminal domain of pro-BDNF is cleaved by a distinct protein convertase enzyme to form 13 kDa biologically active mature BDNF (mBDNF) [10–12].


Brain-derived neurotrophic factor and its clinical implications.

Bathina S, Das UN - Arch Med Sci (2015)

The above figure illustrates the fact of origin of pro-BDNF in endoplasmic reticulum (ER), which is later transported to the Golgi complex (GC) and then to the trans-Golgi network (TGN). From here in the regulated pathway, by the action of CPE and convertase, 13 KDa mature BDNF (mBDNF) is formed and released outside the plasma membrane. This figure is adapted from ref. [13]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697050&req=5

Figure 0001: The above figure illustrates the fact of origin of pro-BDNF in endoplasmic reticulum (ER), which is later transported to the Golgi complex (GC) and then to the trans-Golgi network (TGN). From here in the regulated pathway, by the action of CPE and convertase, 13 KDa mature BDNF (mBDNF) is formed and released outside the plasma membrane. This figure is adapted from ref. [13]
Mentions: BDNF is a member of the neurotrophin family of growth factors along with nerve growth factor (NGF); neurotrophins-3 (NT-3), NT4/5 and NT-6. BDNF is synthesized in the endoplasmic reticulum (ER) as a 32–35 kDa precursor protein (pro BDNF) that moves through the Golgi apparatus and trans-Golgi network (TGN). In the presence of lipid raft associated sorting receptor carboxy peptidase E (CPE), pro-BDNF is sorted by vesicles and subsequently transported into activity-dependent secretion by post-synaptic dendrites (Figure 1). The terminal domain of pro-BDNF is cleaved by a distinct protein convertase enzyme to form 13 kDa biologically active mature BDNF (mBDNF) [10–12].

Bottom Line: It is widely expressed in the CNS, gut and other tissues.BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival.Thus, BDNF may be useful in the prevention and management of several diseases including diabetes mellitus.

View Article: PubMed Central - PubMed

Affiliation: Bio-Science Research Center, Gayatri Vidya Parishad College of Engineering, Visakhapatnam, India.

ABSTRACT
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues. BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival. BDNF and insulin-like growth factor-1 have similar downstream signaling mechanisms incorporating both p-CAMK and MAPK that increase the expression of pro-survival genes. Brain-derived neurotrophic factor regulates glucose and energy metabolism and prevents exhaustion of β cells. Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Thus, BDNF may be useful in the prevention and management of several diseases including diabetes mellitus.

No MeSH data available.


Related in: MedlinePlus