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Interleukin 18 as an early marker or prognostic factor in acute pancreatitis.

Janiak A, Leśniowski B, Jasińska A, Pietruczuk M, Małecka-Panas E - Prz Gastroenterol (2015)

Bottom Line: Acute pancreatits (AP) still reqiures better diagnostic and therapeutic options to be introduced in order to decrease its morbidity and mortality.Mean IL-18 study group levels were 128.4 ±7.6 pg/ml on the 1(st), 112.0 ±4.4 pg/ml on the 3(rd), and 122.8 ±6.8 pg/ml on the 5(th) day of AP, and were significantly higher than those in the control group, accordingly: p < 0.001, p < 0.005, p < 0.001.A slight increase in correlation was observed as the days went by.

View Article: PubMed Central - PubMed

Affiliation: Department of General and Transplantological Surgery, Medical University of Lodz, Lodz, Poland.

ABSTRACT

Introduction: Acute pancreatits (AP) still reqiures better diagnostic and therapeutic options to be introduced in order to decrease its morbidity and mortality. It appears that the assessment of serum levels of interleukin 18 (IL-18) and its correlation with C-reactive protein (CRP) may provide adequate prognostic value.

Aim: To measure serum concentrations of IL-18 and inflammation markers such as CRP in patients with AP during subsequent hospital stay days and to assess the role of IL-18 as an early AP marker and prognostic factor.

Material and methods: Thirty-two patients aged 47 ±16.7 years were included into the study (17 males and 15 females), in whom AP was diagnosed based on ultrasound and computer aided tomography imaging and amylase. Serum amylase, CRP, and IL-18 levels were measured on the 1(st), 2(nd), 3(rd), and 5(th) days of hospital stay. All patients were scored "B" according to Balthazar and mild AP based on Ranson criteria. The control group consisted of 30 healthy volunteers aged 50.7 ±12.4 years (15 males and 15 females).

Results: The average IL-18 serum level in the control group was 86.91 ±4.94 pg/ml. Mean IL-18 study group levels were 128.4 ±7.6 pg/ml on the 1(st), 112.0 ±4.4 pg/ml on the 3(rd), and 122.8 ±6.8 pg/ml on the 5(th) day of AP, and were significantly higher than those in the control group, accordingly: p < 0.001, p < 0.005, p < 0.001. A positive correlation between IL-18 and CRP serum concentrations was observed. A slight increase in correlation was observed as the days went by.

Conclusions: We concluded that the serum IL-18 level increases in the initial phase of AP, and it may be used as an inflammatory reaction marker in patients with AP, and it is correlated with CRP, which may indicate its prognostic role in AP.

No MeSH data available.


Related in: MedlinePlus

The IL-18 serum concentration in the study groups*p < 0.001 compared to the control group, **p < 0.005 compared to the control group.
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Figure 0001: The IL-18 serum concentration in the study groups*p < 0.001 compared to the control group, **p < 0.005 compared to the control group.

Mentions: The average IL-18 serum level in the control group was 86.91 ±4.94 pg/ml. The IL-18 study-group levels were: 128.4 ±7.6 pg/ml on the first, 112.0 ±4.4 pg/ml on the third, and 122.8 ±6.8 pg/ml on the fifth day of AP, and they were significantly higher than in the control group, accordingly p < 0.001, p < 0.005, p < 0.001. The increase in IL-18 level amounted to 49% on the first, 30% on the third, and 42% on the fifth day, in comparison to the control group (Figure 1).


Interleukin 18 as an early marker or prognostic factor in acute pancreatitis.

Janiak A, Leśniowski B, Jasińska A, Pietruczuk M, Małecka-Panas E - Prz Gastroenterol (2015)

The IL-18 serum concentration in the study groups*p < 0.001 compared to the control group, **p < 0.005 compared to the control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697031&req=5

Figure 0001: The IL-18 serum concentration in the study groups*p < 0.001 compared to the control group, **p < 0.005 compared to the control group.
Mentions: The average IL-18 serum level in the control group was 86.91 ±4.94 pg/ml. The IL-18 study-group levels were: 128.4 ±7.6 pg/ml on the first, 112.0 ±4.4 pg/ml on the third, and 122.8 ±6.8 pg/ml on the fifth day of AP, and they were significantly higher than in the control group, accordingly p < 0.001, p < 0.005, p < 0.001. The increase in IL-18 level amounted to 49% on the first, 30% on the third, and 42% on the fifth day, in comparison to the control group (Figure 1).

Bottom Line: Acute pancreatits (AP) still reqiures better diagnostic and therapeutic options to be introduced in order to decrease its morbidity and mortality.Mean IL-18 study group levels were 128.4 ±7.6 pg/ml on the 1(st), 112.0 ±4.4 pg/ml on the 3(rd), and 122.8 ±6.8 pg/ml on the 5(th) day of AP, and were significantly higher than those in the control group, accordingly: p < 0.001, p < 0.005, p < 0.001.A slight increase in correlation was observed as the days went by.

View Article: PubMed Central - PubMed

Affiliation: Department of General and Transplantological Surgery, Medical University of Lodz, Lodz, Poland.

ABSTRACT

Introduction: Acute pancreatits (AP) still reqiures better diagnostic and therapeutic options to be introduced in order to decrease its morbidity and mortality. It appears that the assessment of serum levels of interleukin 18 (IL-18) and its correlation with C-reactive protein (CRP) may provide adequate prognostic value.

Aim: To measure serum concentrations of IL-18 and inflammation markers such as CRP in patients with AP during subsequent hospital stay days and to assess the role of IL-18 as an early AP marker and prognostic factor.

Material and methods: Thirty-two patients aged 47 ±16.7 years were included into the study (17 males and 15 females), in whom AP was diagnosed based on ultrasound and computer aided tomography imaging and amylase. Serum amylase, CRP, and IL-18 levels were measured on the 1(st), 2(nd), 3(rd), and 5(th) days of hospital stay. All patients were scored "B" according to Balthazar and mild AP based on Ranson criteria. The control group consisted of 30 healthy volunteers aged 50.7 ±12.4 years (15 males and 15 females).

Results: The average IL-18 serum level in the control group was 86.91 ±4.94 pg/ml. Mean IL-18 study group levels were 128.4 ±7.6 pg/ml on the 1(st), 112.0 ±4.4 pg/ml on the 3(rd), and 122.8 ±6.8 pg/ml on the 5(th) day of AP, and were significantly higher than those in the control group, accordingly: p < 0.001, p < 0.005, p < 0.001. A positive correlation between IL-18 and CRP serum concentrations was observed. A slight increase in correlation was observed as the days went by.

Conclusions: We concluded that the serum IL-18 level increases in the initial phase of AP, and it may be used as an inflammatory reaction marker in patients with AP, and it is correlated with CRP, which may indicate its prognostic role in AP.

No MeSH data available.


Related in: MedlinePlus