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Optical rhinometry in nasal provocation testing.

Krzych-Fałta E, Sybilski A, Wojas O, Samoliński B - Postepy Dermatol Alergol (2015)

Bottom Line: The study group included 60 subjects: 30 patients diagnosed with an allergy to common environmental allergens (dust mites/grasses) and 30 healthy controls.These objective changes in optical density strongly correlated with subjective perception measured via a visual analog scale.Optical rhinometry is a valuable tool for nasal allergen provocation testing.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Risk Prevention and Allergology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland. Head of the Department: Prof. Bolesław Samoliński MD, PhD.

ABSTRACT

Introduction: Optical rhinometry (ORM) is a technique that allows for direct continuous measurement of changes in blood flow (optical density) in nasal vessels, at the same time analyzing changes per unit of time in the evaluated variable: intravascular blood flow and oxygen saturation.

Aim: To assess the extent to which ORM can be used as an objective measure of nasal mucosal edema following a nasal allergen provocation test in a group of patients with allergic rhinitis versus healthy controls.

Material and methods: The study group included 60 subjects: 30 patients diagnosed with an allergy to common environmental allergens (dust mites/grasses) and 30 healthy controls. The method used in the study was a nasal provocation test with an allergen, with a standard dose of a control solution and an allergen (5,000 SBU/ml) administered using a calibrated atomizer into both nostrils in room temperature.

Results: The mean delay to the onset of nasal mucosal response as measured by ORM was 3.15 min and the level of light extinction returned to baseline after 28.15 min (change in optical density 0.431). These objective changes in optical density strongly correlated with subjective perception measured via a visual analog scale.

Conclusions: Optical rhinometry is a valuable tool for nasal allergen provocation testing.

No MeSH data available.


Related in: MedlinePlus

The relationship between symptoms recorded via VAS and nasal mucosal edema recorded via optical rhinometry. A – Nasal irritation (r = 0.13, p = 0.016), B – rhinorrhea (r = 0.493, p < 0.005), C – nasal congestion (r = 0.333, p = 0.009)
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Figure 0003: The relationship between symptoms recorded via VAS and nasal mucosal edema recorded via optical rhinometry. A – Nasal irritation (r = 0.13, p = 0.016), B – rhinorrhea (r = 0.493, p < 0.005), C – nasal congestion (r = 0.333, p = 0.009)

Mentions: In the AR group, there were significant differences both in terms of mean change in infrared light absorption and in the onset of allergic reaction in comparison with the control group (p < 0.05) (Figure 1). The mean onset of mucosal reaction on the optical rhinometry curve was recorded after 3.15 min, while light extinction returned to its lowest (baseline) level after 28.15 min. The mean value of infrared light absorption in the AR group in comparison with that in the control group was OD = 0.431 (p < 0.05). We observed strong correlations between symptoms recorded via the VAS (nasal irritation r = 0.13, p = 0.016; rhinorrhea r = 0.493, p < 0.005; nasal congestion r = 0.333, p = 0.009) and ORM between 5 and 20 min following nasal allergen administration (Figure 3).


Optical rhinometry in nasal provocation testing.

Krzych-Fałta E, Sybilski A, Wojas O, Samoliński B - Postepy Dermatol Alergol (2015)

The relationship between symptoms recorded via VAS and nasal mucosal edema recorded via optical rhinometry. A – Nasal irritation (r = 0.13, p = 0.016), B – rhinorrhea (r = 0.493, p < 0.005), C – nasal congestion (r = 0.333, p = 0.009)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697026&req=5

Figure 0003: The relationship between symptoms recorded via VAS and nasal mucosal edema recorded via optical rhinometry. A – Nasal irritation (r = 0.13, p = 0.016), B – rhinorrhea (r = 0.493, p < 0.005), C – nasal congestion (r = 0.333, p = 0.009)
Mentions: In the AR group, there were significant differences both in terms of mean change in infrared light absorption and in the onset of allergic reaction in comparison with the control group (p < 0.05) (Figure 1). The mean onset of mucosal reaction on the optical rhinometry curve was recorded after 3.15 min, while light extinction returned to its lowest (baseline) level after 28.15 min. The mean value of infrared light absorption in the AR group in comparison with that in the control group was OD = 0.431 (p < 0.05). We observed strong correlations between symptoms recorded via the VAS (nasal irritation r = 0.13, p = 0.016; rhinorrhea r = 0.493, p < 0.005; nasal congestion r = 0.333, p = 0.009) and ORM between 5 and 20 min following nasal allergen administration (Figure 3).

Bottom Line: The study group included 60 subjects: 30 patients diagnosed with an allergy to common environmental allergens (dust mites/grasses) and 30 healthy controls.These objective changes in optical density strongly correlated with subjective perception measured via a visual analog scale.Optical rhinometry is a valuable tool for nasal allergen provocation testing.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Risk Prevention and Allergology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland. Head of the Department: Prof. Bolesław Samoliński MD, PhD.

ABSTRACT

Introduction: Optical rhinometry (ORM) is a technique that allows for direct continuous measurement of changes in blood flow (optical density) in nasal vessels, at the same time analyzing changes per unit of time in the evaluated variable: intravascular blood flow and oxygen saturation.

Aim: To assess the extent to which ORM can be used as an objective measure of nasal mucosal edema following a nasal allergen provocation test in a group of patients with allergic rhinitis versus healthy controls.

Material and methods: The study group included 60 subjects: 30 patients diagnosed with an allergy to common environmental allergens (dust mites/grasses) and 30 healthy controls. The method used in the study was a nasal provocation test with an allergen, with a standard dose of a control solution and an allergen (5,000 SBU/ml) administered using a calibrated atomizer into both nostrils in room temperature.

Results: The mean delay to the onset of nasal mucosal response as measured by ORM was 3.15 min and the level of light extinction returned to baseline after 28.15 min (change in optical density 0.431). These objective changes in optical density strongly correlated with subjective perception measured via a visual analog scale.

Conclusions: Optical rhinometry is a valuable tool for nasal allergen provocation testing.

No MeSH data available.


Related in: MedlinePlus