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Expression of CXCR4 and CXCL12 and their correlations to the cell proliferation and angiogenesis in mycosis fungoides.

Maj J, Jankowska-Konsur AM, Hałoń A, Woźniak Z, Plomer-Niezgoda E, Reich A - Postepy Dermatol Alergol (2015)

Bottom Line: The expression of chemokine CXCL12 and its receptor CXCR4 was significantly higher in MF than in the healthy skin (p < 0.001).There was no significant difference between early and advanced stages of MF.Therefore, the CXCR4/CXCL12 axis seems to be an interesting potential target for the future strategies of new drug development, giving hope for more efficacious therapies for mycosis fungoides.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. Head of the Department: Prof. Jacek Szepietowski MD, PhD.

ABSTRACT

Introduction: Chemokines play an important role in tumor growth, invasion and metastasis. The CXCR4/CXCL12 axis has been implicated in development of both solid tumors and hematological malignancies and is also relevant in the pathogenesis of the most common primary cutaneous T-cell lymphoma, mycosis fungoides (MF).

Aim: To evaluate the expression of CXCR4 and CXCL12 in MF and to examine their associations with cell proliferation and angiogenesis.

Material and methods: The material for the study consisted of skin samples obtained from 56 patients with MF and 20 healthy volunteers. The expression of CXCR4 and CXCL12 was assessed by immunohistochemistry on the paraffin blocks and compared to the expression of angiogenesis marker (CD34) and proliferation indicators (Ki-67, AgNORs).

Results: The expression of chemokine CXCL12 and its receptor CXCR4 was significantly higher in MF than in the healthy skin (p < 0.001). There was no significant difference between early and advanced stages of MF. Similarly, there was no statistically important correlation between the expression of CXCR4/CXCL12 and angiogenesis and proliferation markers, however a significant correlation between CD34 and AgNORs expression was found (p < 0.001).

Conclusions: The CXCR4/CXCL12 axis seems to play an important role in MF development in the early as well as in the advanced stages of the disease. Therefore, the CXCR4/CXCL12 axis seems to be an interesting potential target for the future strategies of new drug development, giving hope for more efficacious therapies for mycosis fungoides.

No MeSH data available.


Related in: MedlinePlus

The expression of Ki-67 in mycosis fungoides (magnification 400×)
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Figure 0003: The expression of Ki-67 in mycosis fungoides (magnification 400×)

Mentions: To establish the importance of CXCL12 and CXCR4 for the prognosis of mycosis fungoides we have compared them with the well-known markers of tumor progression like Ki67, CD34 and AgNORs (Figures 2, 3). We did not observe any significant correlations between IRS of CXCL12 and CXCR4 and the expression of analyzed proliferation and angiogenesis markers (Table 3). On the other hand, the expression of all three proliferation parameters significantly correlated between themselves (Table 3). The age and gender of included patients did not significantly influence the expression of any of the studied parameters (data not shown).


Expression of CXCR4 and CXCL12 and their correlations to the cell proliferation and angiogenesis in mycosis fungoides.

Maj J, Jankowska-Konsur AM, Hałoń A, Woźniak Z, Plomer-Niezgoda E, Reich A - Postepy Dermatol Alergol (2015)

The expression of Ki-67 in mycosis fungoides (magnification 400×)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697019&req=5

Figure 0003: The expression of Ki-67 in mycosis fungoides (magnification 400×)
Mentions: To establish the importance of CXCL12 and CXCR4 for the prognosis of mycosis fungoides we have compared them with the well-known markers of tumor progression like Ki67, CD34 and AgNORs (Figures 2, 3). We did not observe any significant correlations between IRS of CXCL12 and CXCR4 and the expression of analyzed proliferation and angiogenesis markers (Table 3). On the other hand, the expression of all three proliferation parameters significantly correlated between themselves (Table 3). The age and gender of included patients did not significantly influence the expression of any of the studied parameters (data not shown).

Bottom Line: The expression of chemokine CXCL12 and its receptor CXCR4 was significantly higher in MF than in the healthy skin (p < 0.001).There was no significant difference between early and advanced stages of MF.Therefore, the CXCR4/CXCL12 axis seems to be an interesting potential target for the future strategies of new drug development, giving hope for more efficacious therapies for mycosis fungoides.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. Head of the Department: Prof. Jacek Szepietowski MD, PhD.

ABSTRACT

Introduction: Chemokines play an important role in tumor growth, invasion and metastasis. The CXCR4/CXCL12 axis has been implicated in development of both solid tumors and hematological malignancies and is also relevant in the pathogenesis of the most common primary cutaneous T-cell lymphoma, mycosis fungoides (MF).

Aim: To evaluate the expression of CXCR4 and CXCL12 in MF and to examine their associations with cell proliferation and angiogenesis.

Material and methods: The material for the study consisted of skin samples obtained from 56 patients with MF and 20 healthy volunteers. The expression of CXCR4 and CXCL12 was assessed by immunohistochemistry on the paraffin blocks and compared to the expression of angiogenesis marker (CD34) and proliferation indicators (Ki-67, AgNORs).

Results: The expression of chemokine CXCL12 and its receptor CXCR4 was significantly higher in MF than in the healthy skin (p < 0.001). There was no significant difference between early and advanced stages of MF. Similarly, there was no statistically important correlation between the expression of CXCR4/CXCL12 and angiogenesis and proliferation markers, however a significant correlation between CD34 and AgNORs expression was found (p < 0.001).

Conclusions: The CXCR4/CXCL12 axis seems to play an important role in MF development in the early as well as in the advanced stages of the disease. Therefore, the CXCR4/CXCL12 axis seems to be an interesting potential target for the future strategies of new drug development, giving hope for more efficacious therapies for mycosis fungoides.

No MeSH data available.


Related in: MedlinePlus