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Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease.

Kierszniewska-Stępień D, Pietras T, Ciebiada M, Górski P, Stępień H - Postepy Dermatol Alergol (2015)

Bottom Line: Detailed history was taken, physical examination and spirometry tests were done and blood samples were taken for evaluation of serum concentrations of Ang-1, Ang-2 and Tie.The concentrations of Ang-1 and Ang-2 were not significantly greater in patients with COPD than in healthy controls.The concentrations of Ang-2 were not significantly higher in patients with moderate COPD when compared with those with severe and very severe disease and healthy smokers, and were significantly higher than in healthy non-smokers.

View Article: PubMed Central - PubMed

Affiliation: Department of Pneumonology and Allergy, Medical University of Lodz, Lodz, Poland. Head of the Department: Prof. Paweł Górski MD, PhD.

ABSTRACT

Introduction: Both angiopoietins (angiopoietin 1 - Ang-1, angiopoietin 2 - Ang-2) and angiopoietin receptors (Tie) are involved in angiogenesis and vascular remodeling.

Aim: To assess concentrations of Ang-1, Ang-2 and Tie-2 in blood of patients with chronic obstructive pulmonary disease (COPD) and evaluate if their concentrations depend on the severity of the disease.

Material and methods: Thirty patients with COPD (stage II-IV) and 8 healthy smokers as well as 8 healthy non-smokers were included in the study. Detailed history was taken, physical examination and spirometry tests were done and blood samples were taken for evaluation of serum concentrations of Ang-1, Ang-2 and Tie.

Results: Among COPD patients, 8 patients suffered from moderate disease, 8 patients had severe, while 14 patients had very severe disease. The concentrations of Ang-1 and Ang-2 were not significantly greater in patients with COPD than in healthy controls. The highest concentrations of Ang-1 and Ang-2 were observed in patients with moderate COPD, and levels of Ang-2 correlated with Tie-2 in this group of patients. The levels of Ang-1 were the lowest in healthy non-smokers and in patients with severe COPD, where they inversely correlated with Tie-2. The concentrations of Ang-2 were not significantly higher in patients with moderate COPD when compared with those with severe and very severe disease and healthy smokers, and were significantly higher than in healthy non-smokers.

Conclusions: It is possible that Ang-1, Ang-2 and Tie-2 play an important role especially in the early stage of COPD but not in the late phase when vascular complications of the disease occur.

No MeSH data available.


Related in: MedlinePlus

Concentrations of Ang-2 in peripheral blood of patients with moderate, severe and very severe COPD and in healthy controls. Values presented as mean ± SEM
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Figure 0002: Concentrations of Ang-2 in peripheral blood of patients with moderate, severe and very severe COPD and in healthy controls. Values presented as mean ± SEM

Mentions: The concentration of Ang-2 was higher in patients with COPD than in healthy controls. The highest concentration of Ang-2 was observed in patients with moderate COPD (10843.3 ±3333.3 pg/ml), although it was not significantly higher when compared with concentrations observed in patients with severe and very severe COPD and healthy smokers, and was significantly higher than in healthy non-smokers (5093.3 ±896.7 pg/ml) (Figure 2).


Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease.

Kierszniewska-Stępień D, Pietras T, Ciebiada M, Górski P, Stępień H - Postepy Dermatol Alergol (2015)

Concentrations of Ang-2 in peripheral blood of patients with moderate, severe and very severe COPD and in healthy controls. Values presented as mean ± SEM
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4697017&req=5

Figure 0002: Concentrations of Ang-2 in peripheral blood of patients with moderate, severe and very severe COPD and in healthy controls. Values presented as mean ± SEM
Mentions: The concentration of Ang-2 was higher in patients with COPD than in healthy controls. The highest concentration of Ang-2 was observed in patients with moderate COPD (10843.3 ±3333.3 pg/ml), although it was not significantly higher when compared with concentrations observed in patients with severe and very severe COPD and healthy smokers, and was significantly higher than in healthy non-smokers (5093.3 ±896.7 pg/ml) (Figure 2).

Bottom Line: Detailed history was taken, physical examination and spirometry tests were done and blood samples were taken for evaluation of serum concentrations of Ang-1, Ang-2 and Tie.The concentrations of Ang-1 and Ang-2 were not significantly greater in patients with COPD than in healthy controls.The concentrations of Ang-2 were not significantly higher in patients with moderate COPD when compared with those with severe and very severe disease and healthy smokers, and were significantly higher than in healthy non-smokers.

View Article: PubMed Central - PubMed

Affiliation: Department of Pneumonology and Allergy, Medical University of Lodz, Lodz, Poland. Head of the Department: Prof. Paweł Górski MD, PhD.

ABSTRACT

Introduction: Both angiopoietins (angiopoietin 1 - Ang-1, angiopoietin 2 - Ang-2) and angiopoietin receptors (Tie) are involved in angiogenesis and vascular remodeling.

Aim: To assess concentrations of Ang-1, Ang-2 and Tie-2 in blood of patients with chronic obstructive pulmonary disease (COPD) and evaluate if their concentrations depend on the severity of the disease.

Material and methods: Thirty patients with COPD (stage II-IV) and 8 healthy smokers as well as 8 healthy non-smokers were included in the study. Detailed history was taken, physical examination and spirometry tests were done and blood samples were taken for evaluation of serum concentrations of Ang-1, Ang-2 and Tie.

Results: Among COPD patients, 8 patients suffered from moderate disease, 8 patients had severe, while 14 patients had very severe disease. The concentrations of Ang-1 and Ang-2 were not significantly greater in patients with COPD than in healthy controls. The highest concentrations of Ang-1 and Ang-2 were observed in patients with moderate COPD, and levels of Ang-2 correlated with Tie-2 in this group of patients. The levels of Ang-1 were the lowest in healthy non-smokers and in patients with severe COPD, where they inversely correlated with Tie-2. The concentrations of Ang-2 were not significantly higher in patients with moderate COPD when compared with those with severe and very severe disease and healthy smokers, and were significantly higher than in healthy non-smokers.

Conclusions: It is possible that Ang-1, Ang-2 and Tie-2 play an important role especially in the early stage of COPD but not in the late phase when vascular complications of the disease occur.

No MeSH data available.


Related in: MedlinePlus