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Interplay Between Metabolism and Oncogenic Process: Role of microRNAs.

Arora A, Singh S, Bhatt AN, Pandey S, Sandhir R, Dwarakanath BS - Transl Oncogenomics (2015)

Bottom Line: Cancer is a complex disease that arises from the alterations in the composition and regulation of several genes leading to the disturbances in signaling pathways, resulting in the dysregulation of cell proliferation and death as well as the ability of transformed cells to invade the host tissue and metastasize.The process of metabolic reprograming is linked to the activation of oncogenes and/or suppression of tumor suppressor genes, which are further regulated by microRNAs (miRNAs) that play important roles in the interplay between oncogenic process and metabolic reprograming.Looking at the advances made in the recent past, it appears that the translation of knowledge from research in the areas of metabolism, miRNA, and therapeutic response will lead to paradigm shift in the management of this disease.

View Article: PubMed Central - PubMed

Affiliation: Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.; Department of Biochemistry, Panjab University, Chandigarh, India.

ABSTRACT
Cancer is a complex disease that arises from the alterations in the composition and regulation of several genes leading to the disturbances in signaling pathways, resulting in the dysregulation of cell proliferation and death as well as the ability of transformed cells to invade the host tissue and metastasize. It is increasingly becoming clear that metabolic reprograming plays a critical role in tumorigenesis and metastasis. Therefore, targeting this phenotype is considered as a promising approach for the development of therapeutics and adjuvants. The process of metabolic reprograming is linked to the activation of oncogenes and/or suppression of tumor suppressor genes, which are further regulated by microRNAs (miRNAs) that play important roles in the interplay between oncogenic process and metabolic reprograming. Looking at the advances made in the recent past, it appears that the translation of knowledge from research in the areas of metabolism, miRNA, and therapeutic response will lead to paradigm shift in the management of this disease.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram/illustration showing the involvement of miRNAs in regulating the hallmarks of cancer through altered cell metabolism.
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f1-tog-7-2015-011: Schematic diagram/illustration showing the involvement of miRNAs in regulating the hallmarks of cancer through altered cell metabolism.

Mentions: The role of miRNAs in various human metabolic diseases such as obesity, diabetes, and cancer has recently gained increasing attention resulting in a paradigm shift in our understanding of the regulation of cancer metabolism. Emerging picture based on miRNA profiling in the preclinical samples and clinical studies shows that miRNAs regulate the metabolism of normal as well as the transformed cells and plays a critical role in cancer progression/tumor development.25 Available evidences strongly suggest that miRNAs act directly either by targeting key metabolic transporters and metabolic enzymes or by critical signaling pathways by controlling the expression of oncogenes and/or tumor suppressors.7Table 1 provides an overview of the miRNAs involved in the metabolic reprograming of cancer cells and their functions. While majority of the studies suggest that miRNAs regulate the glucose metabolism during the process of tumorigenesis, fewer studies have also suggested the potential role of altered glucose metabolism in regulating miRNAs contributing to the disease progression.26–29 The interplay between oncogenic transformation-driven metabolic reprograming and aberrant miRNAs regulation further establishes their critical role in initiation, promotion, and progression of cancers30–32 by creating a pro-tumorigenic microenvironment, thus orchestrating processes of evasion of apoptosis, angiogenesis, and invasion/migration as well as metastases (Fig. 1).20 A plethora of evidences indicating the differential expression of miRNAs in normal and tumor samples suggest that miRNAs could serve as useful tumor profiling tools. The conventional, high-throughput oligonucleotide miRNA microarray technique, along with its multiple numbers of variations, makes it possible to profile substantial sample numbers with relative ease.33,34 It appears that the expression and activation of glucose metabolism-linked miRNAs can act as biomarker signatures together with the metabolic status and may help in the prediction of disease progression and the design of appropriate therapy in the near future. The roles of miRNA in cancer metabolism in relation to proliferation, cell cycle regulation, and cell death and the potential of miRNA related to metabolic reprograming as therapeutic targets have been reviewed earlier.22,35 This review focuses mainly on the interplay between miRNA regulation and metabolic reprograming, with an emphasis on their potential to influence various hallmark phenotypes associated with carcinogenesis as well as tumorigenesis, such as proliferation, apoptosis, angiogenesis, migration, invasion, and metastasis.


Interplay Between Metabolism and Oncogenic Process: Role of microRNAs.

Arora A, Singh S, Bhatt AN, Pandey S, Sandhir R, Dwarakanath BS - Transl Oncogenomics (2015)

Schematic diagram/illustration showing the involvement of miRNAs in regulating the hallmarks of cancer through altered cell metabolism.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4696840&req=5

f1-tog-7-2015-011: Schematic diagram/illustration showing the involvement of miRNAs in regulating the hallmarks of cancer through altered cell metabolism.
Mentions: The role of miRNAs in various human metabolic diseases such as obesity, diabetes, and cancer has recently gained increasing attention resulting in a paradigm shift in our understanding of the regulation of cancer metabolism. Emerging picture based on miRNA profiling in the preclinical samples and clinical studies shows that miRNAs regulate the metabolism of normal as well as the transformed cells and plays a critical role in cancer progression/tumor development.25 Available evidences strongly suggest that miRNAs act directly either by targeting key metabolic transporters and metabolic enzymes or by critical signaling pathways by controlling the expression of oncogenes and/or tumor suppressors.7Table 1 provides an overview of the miRNAs involved in the metabolic reprograming of cancer cells and their functions. While majority of the studies suggest that miRNAs regulate the glucose metabolism during the process of tumorigenesis, fewer studies have also suggested the potential role of altered glucose metabolism in regulating miRNAs contributing to the disease progression.26–29 The interplay between oncogenic transformation-driven metabolic reprograming and aberrant miRNAs regulation further establishes their critical role in initiation, promotion, and progression of cancers30–32 by creating a pro-tumorigenic microenvironment, thus orchestrating processes of evasion of apoptosis, angiogenesis, and invasion/migration as well as metastases (Fig. 1).20 A plethora of evidences indicating the differential expression of miRNAs in normal and tumor samples suggest that miRNAs could serve as useful tumor profiling tools. The conventional, high-throughput oligonucleotide miRNA microarray technique, along with its multiple numbers of variations, makes it possible to profile substantial sample numbers with relative ease.33,34 It appears that the expression and activation of glucose metabolism-linked miRNAs can act as biomarker signatures together with the metabolic status and may help in the prediction of disease progression and the design of appropriate therapy in the near future. The roles of miRNA in cancer metabolism in relation to proliferation, cell cycle regulation, and cell death and the potential of miRNA related to metabolic reprograming as therapeutic targets have been reviewed earlier.22,35 This review focuses mainly on the interplay between miRNA regulation and metabolic reprograming, with an emphasis on their potential to influence various hallmark phenotypes associated with carcinogenesis as well as tumorigenesis, such as proliferation, apoptosis, angiogenesis, migration, invasion, and metastasis.

Bottom Line: Cancer is a complex disease that arises from the alterations in the composition and regulation of several genes leading to the disturbances in signaling pathways, resulting in the dysregulation of cell proliferation and death as well as the ability of transformed cells to invade the host tissue and metastasize.The process of metabolic reprograming is linked to the activation of oncogenes and/or suppression of tumor suppressor genes, which are further regulated by microRNAs (miRNAs) that play important roles in the interplay between oncogenic process and metabolic reprograming.Looking at the advances made in the recent past, it appears that the translation of knowledge from research in the areas of metabolism, miRNA, and therapeutic response will lead to paradigm shift in the management of this disease.

View Article: PubMed Central - PubMed

Affiliation: Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.; Department of Biochemistry, Panjab University, Chandigarh, India.

ABSTRACT
Cancer is a complex disease that arises from the alterations in the composition and regulation of several genes leading to the disturbances in signaling pathways, resulting in the dysregulation of cell proliferation and death as well as the ability of transformed cells to invade the host tissue and metastasize. It is increasingly becoming clear that metabolic reprograming plays a critical role in tumorigenesis and metastasis. Therefore, targeting this phenotype is considered as a promising approach for the development of therapeutics and adjuvants. The process of metabolic reprograming is linked to the activation of oncogenes and/or suppression of tumor suppressor genes, which are further regulated by microRNAs (miRNAs) that play important roles in the interplay between oncogenic process and metabolic reprograming. Looking at the advances made in the recent past, it appears that the translation of knowledge from research in the areas of metabolism, miRNA, and therapeutic response will lead to paradigm shift in the management of this disease.

No MeSH data available.


Related in: MedlinePlus