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Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia.

Horwood PF, Andronico A, Tarantola A, Salje H, Duong V, Mey C, Ly S, Dussart P, Cauchemez S, Buchy P - Emerging Infect. Dis. (2016)

Bottom Line: Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak.We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

View Article: PubMed Central - PubMed

ABSTRACT
Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

No MeSH data available.


Related in: MedlinePlus

Annual probability of enterovirus 71 infection (EV71) in Cambodia during 1994–2011, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age. Serum samples were collected from routine national dengue surveillance in Cambodia.
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Figure 2: Annual probability of enterovirus 71 infection (EV71) in Cambodia during 1994–2011, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age. Serum samples were collected from routine national dengue surveillance in Cambodia.

Mentions: Epidemic curves derived from the seroprevalence data show the dynamics of infection for the whole country (Figure 2) and across the 4 quadrants (Technical Appendix Figure 3). The reconstructed curves were coherent, showing large-scale, countrywide circulation of the virus since 2002. Seroprevalence peaks every 2–3 years indicate a cyclical pattern of EV71 outbreaks. This pattern has been reported from other Asia-Pacific countries (9–11) and probably represents the time needed for establishment of a new cohort of immunologically naive patients. In countries with a larger population, such as China, infection might peak annually (12).


Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia.

Horwood PF, Andronico A, Tarantola A, Salje H, Duong V, Mey C, Ly S, Dussart P, Cauchemez S, Buchy P - Emerging Infect. Dis. (2016)

Annual probability of enterovirus 71 infection (EV71) in Cambodia during 1994–2011, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age. Serum samples were collected from routine national dengue surveillance in Cambodia.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4696711&req=5

Figure 2: Annual probability of enterovirus 71 infection (EV71) in Cambodia during 1994–2011, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age. Serum samples were collected from routine national dengue surveillance in Cambodia.
Mentions: Epidemic curves derived from the seroprevalence data show the dynamics of infection for the whole country (Figure 2) and across the 4 quadrants (Technical Appendix Figure 3). The reconstructed curves were coherent, showing large-scale, countrywide circulation of the virus since 2002. Seroprevalence peaks every 2–3 years indicate a cyclical pattern of EV71 outbreaks. This pattern has been reported from other Asia-Pacific countries (9–11) and probably represents the time needed for establishment of a new cohort of immunologically naive patients. In countries with a larger population, such as China, infection might peak annually (12).

Bottom Line: Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak.We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

View Article: PubMed Central - PubMed

ABSTRACT
Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

No MeSH data available.


Related in: MedlinePlus