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Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia.

Horwood PF, Andronico A, Tarantola A, Salje H, Duong V, Mey C, Ly S, Dussart P, Cauchemez S, Buchy P - Emerging Infect. Dis. (2016)

Bottom Line: Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak.We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

View Article: PubMed Central - PubMed

ABSTRACT
Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

No MeSH data available.


Related in: MedlinePlus

Age-associated seroprevalence of enterovirus 71 (EV71) infection in Cambodia, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age, 2000–2011. Error bars indicate 95% CIs. Serum samples were collected from routine national dengue surveillance in Cambodia.
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Figure 1: Age-associated seroprevalence of enterovirus 71 (EV71) infection in Cambodia, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age, 2000–2011. Error bars indicate 95% CIs. Serum samples were collected from routine national dengue surveillance in Cambodia.

Mentions: Among children in this study, the overall seroprevalence of EV71 neutralizing antibodies was 88.8%: 1,300 (94.8%) of 1,371 (95% CI 93.5%–95.9%) among children 2–15 years of age sampled during 2006–2011 and 216 (64.3%) of 336 (95% CI 58.9%–69.4%) among those 2–7 years of age sampled during 2000–2005 (Figure 1). Seroprevalence did not vary substantially by age group. This profile across age groups remained unchanged in more stringent analyses with higher cutoff values (Technical Appendix Figure 2) in which, despite levels of seropositivity decreasing with higher cutoff titers, the reduction was consistent across all age groups. Seroprevalence of EV71 relative to sex did not differ significantly (89.8% among girls vs. 87.7% among boys; p = 0.18).


Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia.

Horwood PF, Andronico A, Tarantola A, Salje H, Duong V, Mey C, Ly S, Dussart P, Cauchemez S, Buchy P - Emerging Infect. Dis. (2016)

Age-associated seroprevalence of enterovirus 71 (EV71) infection in Cambodia, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age, 2000–2011. Error bars indicate 95% CIs. Serum samples were collected from routine national dengue surveillance in Cambodia.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4696711&req=5

Figure 1: Age-associated seroprevalence of enterovirus 71 (EV71) infection in Cambodia, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age, 2000–2011. Error bars indicate 95% CIs. Serum samples were collected from routine national dengue surveillance in Cambodia.
Mentions: Among children in this study, the overall seroprevalence of EV71 neutralizing antibodies was 88.8%: 1,300 (94.8%) of 1,371 (95% CI 93.5%–95.9%) among children 2–15 years of age sampled during 2006–2011 and 216 (64.3%) of 336 (95% CI 58.9%–69.4%) among those 2–7 years of age sampled during 2000–2005 (Figure 1). Seroprevalence did not vary substantially by age group. This profile across age groups remained unchanged in more stringent analyses with higher cutoff values (Technical Appendix Figure 2) in which, despite levels of seropositivity decreasing with higher cutoff titers, the reduction was consistent across all age groups. Seroprevalence of EV71 relative to sex did not differ significantly (89.8% among girls vs. 87.7% among boys; p = 0.18).

Bottom Line: Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak.We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

View Article: PubMed Central - PubMed

ABSTRACT
Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

No MeSH data available.


Related in: MedlinePlus