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Surveillance of Bacterial Meningitis, Ethiopia, 2012-2013.

Mihret W, Lema T, Merid Y, Kassu A, Abebe W, Moges B, Tenna A, Woldegebriel F, Yidnekachew M, Mekonnen W, Ahmed A, Yamuah L, Silamsaw M, Petros B, Oksnes J, Rosenqvist E, Ayele S, Aseffa A, Caugant DA, Norheim G - Emerging Infect. Dis. (2016)

Bottom Line: Among 139 patients with suspected bacterial meningitis in Ethiopia, 2012-2013, meningococci (19.4%) and pneumococci (12.9%) were the major disease-causing organisms.Meningococcal serogroups detected were A (n = 11), W (n = 7), C (n = 1), and X (n = 1).Affordable, multivalent meningitis vaccines for the African meningitis belt are urgently needed.

View Article: PubMed Central - PubMed

ABSTRACT
Among 139 patients with suspected bacterial meningitis in Ethiopia, 2012-2013, meningococci (19.4%) and pneumococci (12.9%) were the major disease-causing organisms. Meningococcal serogroups detected were A (n = 11), W (n = 7), C (n = 1), and X (n = 1). Affordable, multivalent meningitis vaccines for the African meningitis belt are urgently needed.

No MeSH data available.


Related in: MedlinePlus

Distribution of causative organisms among 139 patients with clinical symptoms of bacterial meningitis in Ethiopia, 2012–2013, as verified by DNA from either meningococci (Neisseria meningitidis, serogroups A, NmA; C; NmC; X, NmX; ; W, NmW; and NG, not serogrouped as A, C, Y, W, or X), Streptococcus pneumoniae (Spn), or Haemophilus influenzae (Hinf) in cerebrospinal fluid.
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Figure 2: Distribution of causative organisms among 139 patients with clinical symptoms of bacterial meningitis in Ethiopia, 2012–2013, as verified by DNA from either meningococci (Neisseria meningitidis, serogroups A, NmA; C; NmC; X, NmX; ; W, NmW; and NG, not serogrouped as A, C, Y, W, or X), Streptococcus pneumoniae (Spn), or Haemophilus influenzae (Hinf) in cerebrospinal fluid.

Mentions: Serogroup distribution differed substantially by geographic region: W dominated in Gondar, A in Hawassa (Figure 2). One case of meningococcal disease caused by serogroup C and 1 caused by serogroup X meningococci were identified in Gondar and Hawassa, respectively. PorA genosubtyping results were available for 19 of the 27 CSF samples containing N. meningitidis DNA; both PorA variable regions were indicated for 15 samples. Samples from Hawassa were P1.20,9 (n = 7), P1.5–11,10–1 (n = 1), P1.5,_ (n = 1) and P1._,9 (n = 1), whereas those from Gondar were P1.5,2 (n = 7), P1._4 (n = 1) and P1._,2 (n = 1). Genotyping of the 4 meningococcal strains isolated showed that 1 was serogroup W, P1.5,2:F1–1:ST11, whereas 3 were serogroup A, P1.20,9:F3–1:ST7. The 3 pneumococcal isolates that were recovered for multilocus sequence typing were sequence types (ST) 8875 (n = 2) and ST289 (n = 1), all from Gondar.


Surveillance of Bacterial Meningitis, Ethiopia, 2012-2013.

Mihret W, Lema T, Merid Y, Kassu A, Abebe W, Moges B, Tenna A, Woldegebriel F, Yidnekachew M, Mekonnen W, Ahmed A, Yamuah L, Silamsaw M, Petros B, Oksnes J, Rosenqvist E, Ayele S, Aseffa A, Caugant DA, Norheim G - Emerging Infect. Dis. (2016)

Distribution of causative organisms among 139 patients with clinical symptoms of bacterial meningitis in Ethiopia, 2012–2013, as verified by DNA from either meningococci (Neisseria meningitidis, serogroups A, NmA; C; NmC; X, NmX; ; W, NmW; and NG, not serogrouped as A, C, Y, W, or X), Streptococcus pneumoniae (Spn), or Haemophilus influenzae (Hinf) in cerebrospinal fluid.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4696686&req=5

Figure 2: Distribution of causative organisms among 139 patients with clinical symptoms of bacterial meningitis in Ethiopia, 2012–2013, as verified by DNA from either meningococci (Neisseria meningitidis, serogroups A, NmA; C; NmC; X, NmX; ; W, NmW; and NG, not serogrouped as A, C, Y, W, or X), Streptococcus pneumoniae (Spn), or Haemophilus influenzae (Hinf) in cerebrospinal fluid.
Mentions: Serogroup distribution differed substantially by geographic region: W dominated in Gondar, A in Hawassa (Figure 2). One case of meningococcal disease caused by serogroup C and 1 caused by serogroup X meningococci were identified in Gondar and Hawassa, respectively. PorA genosubtyping results were available for 19 of the 27 CSF samples containing N. meningitidis DNA; both PorA variable regions were indicated for 15 samples. Samples from Hawassa were P1.20,9 (n = 7), P1.5–11,10–1 (n = 1), P1.5,_ (n = 1) and P1._,9 (n = 1), whereas those from Gondar were P1.5,2 (n = 7), P1._4 (n = 1) and P1._,2 (n = 1). Genotyping of the 4 meningococcal strains isolated showed that 1 was serogroup W, P1.5,2:F1–1:ST11, whereas 3 were serogroup A, P1.20,9:F3–1:ST7. The 3 pneumococcal isolates that were recovered for multilocus sequence typing were sequence types (ST) 8875 (n = 2) and ST289 (n = 1), all from Gondar.

Bottom Line: Among 139 patients with suspected bacterial meningitis in Ethiopia, 2012-2013, meningococci (19.4%) and pneumococci (12.9%) were the major disease-causing organisms.Meningococcal serogroups detected were A (n = 11), W (n = 7), C (n = 1), and X (n = 1).Affordable, multivalent meningitis vaccines for the African meningitis belt are urgently needed.

View Article: PubMed Central - PubMed

ABSTRACT
Among 139 patients with suspected bacterial meningitis in Ethiopia, 2012-2013, meningococci (19.4%) and pneumococci (12.9%) were the major disease-causing organisms. Meningococcal serogroups detected were A (n = 11), W (n = 7), C (n = 1), and X (n = 1). Affordable, multivalent meningitis vaccines for the African meningitis belt are urgently needed.

No MeSH data available.


Related in: MedlinePlus