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Dysembryoplastic Neuroepithelial Tumors.

Suh YL - J Pathol Transl Med (2015)

Bottom Line: Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types.However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent.The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Radiologically, this tumor is characterized by a cortical topography and lack of mass effect or perilesional edema. Partial complex seizures are the most common presentation. Three histologic subtypes of DNTs have been described. Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types. However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent. This review will focus on the clinical, radiographic, histopathological, and immunohistochemical features as well as the molecular genetics of all three variants of DNTs. The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

No MeSH data available.


Related in: MedlinePlus

Squash cytological findings of dysembryoplastic neuroepithelial tumors. (A) Squash preparation shows round, oval to elongated naked nuclei in the mucinous background. (B) The nuclei of oligodendroglioma-like cells (OLCs) are irregular with small indentations or deep grooves, and fine, granular chromatin and 1–4 small nucleoli. There is a large, normal-looking neuron in the mucinous background. (C) OLCs shows multinuclear giant cell formation (inset) and an intranuclear pseudoinclusion. (D) Squash preparation of oligodendroglioma shows smaller, dark nuclei without nucleoli and larger nuclei with granular chromatin and micronucleoli.
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f7-jptm-2015-10-05: Squash cytological findings of dysembryoplastic neuroepithelial tumors. (A) Squash preparation shows round, oval to elongated naked nuclei in the mucinous background. (B) The nuclei of oligodendroglioma-like cells (OLCs) are irregular with small indentations or deep grooves, and fine, granular chromatin and 1–4 small nucleoli. There is a large, normal-looking neuron in the mucinous background. (C) OLCs shows multinuclear giant cell formation (inset) and an intranuclear pseudoinclusion. (D) Squash preparation of oligodendroglioma shows smaller, dark nuclei without nucleoli and larger nuclei with granular chromatin and micronucleoli.

Mentions: The cytological features of squash preparations of DNT during intraoperative consultation are fairly characteristic and reliable for correct intraoperative diagnosis, which helps to determine the appropriate neurosurgical procedure. The floating neurons and extracellular mucin that are typical of DNT are more easily demonstrated in cytological preparations than in frozen sections [34] (Fig. 7A, B). OLCs appear as aggregates or are dispersed around abundant arborizing capillaries or in the mucinous or focal fibrillary background. Round to oval naked nuclei of OLCs are larger than non-neopalstic and neoplastic oligodendrocytes. Cytologically, distinguishing features of OLCs from oligodendrogliomas include frequent indentation of the nuclear membrane and multiple, small nucleoli (Fig. 7C). The nuclei of oligodendrogliomas are round with a smooth outline and contain one or two occasional nucleoli (Fig. 7D). The presence of eosinophilic granular bodies in the background favors DNTs rather than oligodendrogliomas.


Dysembryoplastic Neuroepithelial Tumors.

Suh YL - J Pathol Transl Med (2015)

Squash cytological findings of dysembryoplastic neuroepithelial tumors. (A) Squash preparation shows round, oval to elongated naked nuclei in the mucinous background. (B) The nuclei of oligodendroglioma-like cells (OLCs) are irregular with small indentations or deep grooves, and fine, granular chromatin and 1–4 small nucleoli. There is a large, normal-looking neuron in the mucinous background. (C) OLCs shows multinuclear giant cell formation (inset) and an intranuclear pseudoinclusion. (D) Squash preparation of oligodendroglioma shows smaller, dark nuclei without nucleoli and larger nuclei with granular chromatin and micronucleoli.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696533&req=5

f7-jptm-2015-10-05: Squash cytological findings of dysembryoplastic neuroepithelial tumors. (A) Squash preparation shows round, oval to elongated naked nuclei in the mucinous background. (B) The nuclei of oligodendroglioma-like cells (OLCs) are irregular with small indentations or deep grooves, and fine, granular chromatin and 1–4 small nucleoli. There is a large, normal-looking neuron in the mucinous background. (C) OLCs shows multinuclear giant cell formation (inset) and an intranuclear pseudoinclusion. (D) Squash preparation of oligodendroglioma shows smaller, dark nuclei without nucleoli and larger nuclei with granular chromatin and micronucleoli.
Mentions: The cytological features of squash preparations of DNT during intraoperative consultation are fairly characteristic and reliable for correct intraoperative diagnosis, which helps to determine the appropriate neurosurgical procedure. The floating neurons and extracellular mucin that are typical of DNT are more easily demonstrated in cytological preparations than in frozen sections [34] (Fig. 7A, B). OLCs appear as aggregates or are dispersed around abundant arborizing capillaries or in the mucinous or focal fibrillary background. Round to oval naked nuclei of OLCs are larger than non-neopalstic and neoplastic oligodendrocytes. Cytologically, distinguishing features of OLCs from oligodendrogliomas include frequent indentation of the nuclear membrane and multiple, small nucleoli (Fig. 7C). The nuclei of oligodendrogliomas are round with a smooth outline and contain one or two occasional nucleoli (Fig. 7D). The presence of eosinophilic granular bodies in the background favors DNTs rather than oligodendrogliomas.

Bottom Line: Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types.However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent.The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Radiologically, this tumor is characterized by a cortical topography and lack of mass effect or perilesional edema. Partial complex seizures are the most common presentation. Three histologic subtypes of DNTs have been described. Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types. However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent. This review will focus on the clinical, radiographic, histopathological, and immunohistochemical features as well as the molecular genetics of all three variants of DNTs. The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

No MeSH data available.


Related in: MedlinePlus