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Dysembryoplastic Neuroepithelial Tumors.

Suh YL - J Pathol Transl Med (2015)

Bottom Line: Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types.However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent.The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Radiologically, this tumor is characterized by a cortical topography and lack of mass effect or perilesional edema. Partial complex seizures are the most common presentation. Three histologic subtypes of DNTs have been described. Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types. However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent. This review will focus on the clinical, radiographic, histopathological, and immunohistochemical features as well as the molecular genetics of all three variants of DNTs. The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

No MeSH data available.


Related in: MedlinePlus

Three different types of magnetic resonance imaging in dysembryoplastic neuroepithelial tumors. (A, B) Type 1 shows a well-delineated, polycystic-like tumor with strongly hypointense on T1- and hyperintense on T2-weighted images. (C, D) Type 2 shows a nodular-like, heterogeneous lesion. (E, F) Type 3 shows a poorly delineated, dysplastic-like, iso/hyposignal T1 with gray-white matter blurring. Type 1 is mainly found in simple or complex forms, and type 2 and 3 are observed in nonspecific forms. (A, C, E) T1-weighted images. (B, D, F) T2 FLARE images.
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f1-jptm-2015-10-05: Three different types of magnetic resonance imaging in dysembryoplastic neuroepithelial tumors. (A, B) Type 1 shows a well-delineated, polycystic-like tumor with strongly hypointense on T1- and hyperintense on T2-weighted images. (C, D) Type 2 shows a nodular-like, heterogeneous lesion. (E, F) Type 3 shows a poorly delineated, dysplastic-like, iso/hyposignal T1 with gray-white matter blurring. Type 1 is mainly found in simple or complex forms, and type 2 and 3 are observed in nonspecific forms. (A, C, E) T1-weighted images. (B, D, F) T2 FLARE images.

Mentions: Recently, MRI features in histologic variants of DNTs are classified into three types as follows: type 1 (cystic/polycystic-like, well-delineated, strongly hypointense on T1), type 2 (nodularlike, heterogeneous signal), or type 3 (dysplastic-like, isosignal/hyposignal T1, poor delineation, gray-white matter blurring) [29] (Fig. 1A–F). Simple or complex DNTs are always seen as type 1 on MRI, whereas nonspecific DNTs are seen as either type 2 or type 3 on MRI. Epileptogenic zones are found to be significantly different among MRI subtypes. The epileptogenic zone co-localizes to the tumor in type 1 MRI and involves the peritumoral cortex in type 2 MRI, while there are more extensive areas involved in type 3 MRI.


Dysembryoplastic Neuroepithelial Tumors.

Suh YL - J Pathol Transl Med (2015)

Three different types of magnetic resonance imaging in dysembryoplastic neuroepithelial tumors. (A, B) Type 1 shows a well-delineated, polycystic-like tumor with strongly hypointense on T1- and hyperintense on T2-weighted images. (C, D) Type 2 shows a nodular-like, heterogeneous lesion. (E, F) Type 3 shows a poorly delineated, dysplastic-like, iso/hyposignal T1 with gray-white matter blurring. Type 1 is mainly found in simple or complex forms, and type 2 and 3 are observed in nonspecific forms. (A, C, E) T1-weighted images. (B, D, F) T2 FLARE images.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4696533&req=5

f1-jptm-2015-10-05: Three different types of magnetic resonance imaging in dysembryoplastic neuroepithelial tumors. (A, B) Type 1 shows a well-delineated, polycystic-like tumor with strongly hypointense on T1- and hyperintense on T2-weighted images. (C, D) Type 2 shows a nodular-like, heterogeneous lesion. (E, F) Type 3 shows a poorly delineated, dysplastic-like, iso/hyposignal T1 with gray-white matter blurring. Type 1 is mainly found in simple or complex forms, and type 2 and 3 are observed in nonspecific forms. (A, C, E) T1-weighted images. (B, D, F) T2 FLARE images.
Mentions: Recently, MRI features in histologic variants of DNTs are classified into three types as follows: type 1 (cystic/polycystic-like, well-delineated, strongly hypointense on T1), type 2 (nodularlike, heterogeneous signal), or type 3 (dysplastic-like, isosignal/hyposignal T1, poor delineation, gray-white matter blurring) [29] (Fig. 1A–F). Simple or complex DNTs are always seen as type 1 on MRI, whereas nonspecific DNTs are seen as either type 2 or type 3 on MRI. Epileptogenic zones are found to be significantly different among MRI subtypes. The epileptogenic zone co-localizes to the tumor in type 1 MRI and involves the peritumoral cortex in type 2 MRI, while there are more extensive areas involved in type 3 MRI.

Bottom Line: Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types.However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent.The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Radiologically, this tumor is characterized by a cortical topography and lack of mass effect or perilesional edema. Partial complex seizures are the most common presentation. Three histologic subtypes of DNTs have been described. Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types. However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent. This review will focus on the clinical, radiographic, histopathological, and immunohistochemical features as well as the molecular genetics of all three variants of DNTs. The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.

No MeSH data available.


Related in: MedlinePlus