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Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review.

Chun YK - J Pathol Transl Med (2015)

Bottom Line: Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors.In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described.This review also discusses recent advances in our pathogenetic understanding of these disorders.

View Article: PubMed Central - PubMed

ABSTRACT

Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors. In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described. Differential diagnoses are discussed, especially for non-neuroendocrine tumors showing high-grade nuclei with neuroendocrine differentiation. This review also discusses recent advances in our pathogenetic understanding of these disorders.

No MeSH data available.


Related in: MedlinePlus

(A) Dedifferentiated carcinoma composed of undifferentiated carcinoma and grade 1 endometrioid carcinoma. (B) Dyscohesive tumor cells growing in a patternless fashion without gland formation. Focal positivity of cytokeratin (C) and synaptophysin (D) immunostaining.
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f2-jptm-2015-09-20: (A) Dedifferentiated carcinoma composed of undifferentiated carcinoma and grade 1 endometrioid carcinoma. (B) Dyscohesive tumor cells growing in a patternless fashion without gland formation. Focal positivity of cytokeratin (C) and synaptophysin (D) immunostaining.

Mentions: Morphologically undifferentiated carcinoma is composed of small to intermediate-sized, dyscohesive cells growing in a patternless fashion without gland formation. Most cases have necrosis and more than 25 mitotic figures per 10 HPFs. Immunohistochemical staining for cytokeratin and epithelial membrane antigen (EMA) shows focal positivity, usually in less than 10% of tumor cells. Dedifferentiated carcinoma has different cytologic features in the undifferentiated carcinoma and endometrioid carcinoma components (Fig. 2). On the contrary, poorly differentiated endometrioid carcinoma shows similar tumor cells in the solid and glandular areas (Fig. 3). The solid area often resembles poorly differentiated non-keratinizing squamous cell carcinoma and tends to have a cohesive appearance and diffuse positivity for cytokeratin and EMA [40]. Poorly differentiated endometrioid carcinoma should be distinguished from NEC and undifferentiated/dedifferentiated carcinoma [41]. This distinction has important clinical implications, as endometrioid carcinoma confers a much better prognosis than NEC and undifferentiated/ dedifferentiated carcinoma [42].


Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review.

Chun YK - J Pathol Transl Med (2015)

(A) Dedifferentiated carcinoma composed of undifferentiated carcinoma and grade 1 endometrioid carcinoma. (B) Dyscohesive tumor cells growing in a patternless fashion without gland formation. Focal positivity of cytokeratin (C) and synaptophysin (D) immunostaining.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696532&req=5

f2-jptm-2015-09-20: (A) Dedifferentiated carcinoma composed of undifferentiated carcinoma and grade 1 endometrioid carcinoma. (B) Dyscohesive tumor cells growing in a patternless fashion without gland formation. Focal positivity of cytokeratin (C) and synaptophysin (D) immunostaining.
Mentions: Morphologically undifferentiated carcinoma is composed of small to intermediate-sized, dyscohesive cells growing in a patternless fashion without gland formation. Most cases have necrosis and more than 25 mitotic figures per 10 HPFs. Immunohistochemical staining for cytokeratin and epithelial membrane antigen (EMA) shows focal positivity, usually in less than 10% of tumor cells. Dedifferentiated carcinoma has different cytologic features in the undifferentiated carcinoma and endometrioid carcinoma components (Fig. 2). On the contrary, poorly differentiated endometrioid carcinoma shows similar tumor cells in the solid and glandular areas (Fig. 3). The solid area often resembles poorly differentiated non-keratinizing squamous cell carcinoma and tends to have a cohesive appearance and diffuse positivity for cytokeratin and EMA [40]. Poorly differentiated endometrioid carcinoma should be distinguished from NEC and undifferentiated/dedifferentiated carcinoma [41]. This distinction has important clinical implications, as endometrioid carcinoma confers a much better prognosis than NEC and undifferentiated/ dedifferentiated carcinoma [42].

Bottom Line: Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors.In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described.This review also discusses recent advances in our pathogenetic understanding of these disorders.

View Article: PubMed Central - PubMed

ABSTRACT

Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors. In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described. Differential diagnoses are discussed, especially for non-neuroendocrine tumors showing high-grade nuclei with neuroendocrine differentiation. This review also discusses recent advances in our pathogenetic understanding of these disorders.

No MeSH data available.


Related in: MedlinePlus