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Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review.

Chun YK - J Pathol Transl Med (2015)

Bottom Line: Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors.In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described.This review also discusses recent advances in our pathogenetic understanding of these disorders.

View Article: PubMed Central - PubMed

ABSTRACT

Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors. In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described. Differential diagnoses are discussed, especially for non-neuroendocrine tumors showing high-grade nuclei with neuroendocrine differentiation. This review also discusses recent advances in our pathogenetic understanding of these disorders.

No MeSH data available.


Related in: MedlinePlus

(A) Endometrial large cell neuroendocrine carcinoma (LCNEC) admixed with grade 1 endometrioid carcinoma. (B) Large vesicular nuclei and prominent nucleoli in LCNEC. (C) CD56 immunostaining: positive in endometrioid carcinoma and negative in LCNEC. (D) Diffuse synaptophysin expression in LCNEC.
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f1-jptm-2015-09-20: (A) Endometrial large cell neuroendocrine carcinoma (LCNEC) admixed with grade 1 endometrioid carcinoma. (B) Large vesicular nuclei and prominent nucleoli in LCNEC. (C) CD56 immunostaining: positive in endometrioid carcinoma and negative in LCNEC. (D) Diffuse synaptophysin expression in LCNEC.

Mentions: NECs of the endometrium should be differentiated from various tumors showing high-grade nuclear features with a predominantly solid growth pattern. LCNEC is much more difficult to diagnose than SCNEC, as the tumor might not show the characteristic morphologic features of neuroendocrine differentiation, such as hyperchromatic nuclei, salt and pepper chromatin, and nuclear molding. To establish a diagnosis of endometrial LCNEC, neuroendocrine patterns (nesting, trabeculae, rosettes, and palisading) should be present in at least part of the tumor, along with expression of one or more of the neuroendocrine markers (Fig. 1).


Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review.

Chun YK - J Pathol Transl Med (2015)

(A) Endometrial large cell neuroendocrine carcinoma (LCNEC) admixed with grade 1 endometrioid carcinoma. (B) Large vesicular nuclei and prominent nucleoli in LCNEC. (C) CD56 immunostaining: positive in endometrioid carcinoma and negative in LCNEC. (D) Diffuse synaptophysin expression in LCNEC.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696532&req=5

f1-jptm-2015-09-20: (A) Endometrial large cell neuroendocrine carcinoma (LCNEC) admixed with grade 1 endometrioid carcinoma. (B) Large vesicular nuclei and prominent nucleoli in LCNEC. (C) CD56 immunostaining: positive in endometrioid carcinoma and negative in LCNEC. (D) Diffuse synaptophysin expression in LCNEC.
Mentions: NECs of the endometrium should be differentiated from various tumors showing high-grade nuclear features with a predominantly solid growth pattern. LCNEC is much more difficult to diagnose than SCNEC, as the tumor might not show the characteristic morphologic features of neuroendocrine differentiation, such as hyperchromatic nuclei, salt and pepper chromatin, and nuclear molding. To establish a diagnosis of endometrial LCNEC, neuroendocrine patterns (nesting, trabeculae, rosettes, and palisading) should be present in at least part of the tumor, along with expression of one or more of the neuroendocrine markers (Fig. 1).

Bottom Line: Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors.In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described.This review also discusses recent advances in our pathogenetic understanding of these disorders.

View Article: PubMed Central - PubMed

ABSTRACT

Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors. In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described. Differential diagnoses are discussed, especially for non-neuroendocrine tumors showing high-grade nuclei with neuroendocrine differentiation. This review also discusses recent advances in our pathogenetic understanding of these disorders.

No MeSH data available.


Related in: MedlinePlus