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Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey.

Lee SH, Kim WS, Choi YD, Seo JW, Han JH, Kim MJ, Kim L, Lee GK, Lee CH, Oh MH, Kim GY, Sung SH, Lee KY, Chang SH, Rho MS, Kim HK, Jung SH, Jang SJ, Cardiopulmonary Pathology Study Group of Korean Society of Pathologis - J Pathol Transl Med (2015)

Bottom Line: We compared EGFR mutations with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status.EGFR mutation rate was significantly higher in women, never smokers, patients with adenocarcinoma, and patients who had undergone excisional biopsy.EGFR mutation rates did not differ with respect to patient age or procurement site among patients with NSCLC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Analysis of mutations in the epidermal growth factor receptor gene (EGFR) is important for predicting response to EGFR tyrosine kinase inhibitors. The overall rate of EGFR mutations in Korean patients is variable. To obtain comprehensive data on the status of EGFR mutations in Korean patients with lung cancer, the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists initiated a nationwide survey.

Methods: We obtained 1,753 reports on EGFR mutations in patients with lung cancer from 15 hospitals between January and December 2009. We compared EGFR mutations with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status.

Results: The overall EGFR mutation rate was 34.3% in patients with non-small cell lung cancer (NSCLC) and 43.3% in patients with adenocarcinoma. EGFR mutation rate was significantly higher in women, never smokers, patients with adenocarcinoma, and patients who had undergone excisional biopsy. EGFR mutation rates did not differ with respect to patient age or procurement site among patients with NSCLC.

Conclusions: EGFR mutation rates and statuses were similar to those in published data from other East Asian countries.

No MeSH data available.


Related in: MedlinePlus

Geographical distribution of the 15 hospitals in Korea.
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f1-jptm-2015-09-14: Geographical distribution of the 15 hospitals in Korea.

Mentions: In all, 1,826 reports of EGFR mutation in patients with lung cancer were collected from 15 hospitals between January and December 2009 (Fig. 1). Of these, 24 reports of patients with small cell carcinoma and 49 reports of patients with malignancies from other than lung primary tumors were excluded from the study. Finally, 1,544 reports of primary tumor and 209 reports of metastatic tumor were included in the study. EGFR mutation status was compared with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status. Smoker status was defined as having a greater than 10 pack-year history and currently smoking cigarettes every day or most days. An ex-smoker was someone who had smoked more than 100 cigarettes in their lifetime and who does not currently smoke. A light smoker was defined as a current smoker with a less than 10 pack-year history. A never-smoker was an adult who had never smoked a cigarette or who smoked fewer than 100 cigarettes in their lifetime.


Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey.

Lee SH, Kim WS, Choi YD, Seo JW, Han JH, Kim MJ, Kim L, Lee GK, Lee CH, Oh MH, Kim GY, Sung SH, Lee KY, Chang SH, Rho MS, Kim HK, Jung SH, Jang SJ, Cardiopulmonary Pathology Study Group of Korean Society of Pathologis - J Pathol Transl Med (2015)

Geographical distribution of the 15 hospitals in Korea.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696529&req=5

f1-jptm-2015-09-14: Geographical distribution of the 15 hospitals in Korea.
Mentions: In all, 1,826 reports of EGFR mutation in patients with lung cancer were collected from 15 hospitals between January and December 2009 (Fig. 1). Of these, 24 reports of patients with small cell carcinoma and 49 reports of patients with malignancies from other than lung primary tumors were excluded from the study. Finally, 1,544 reports of primary tumor and 209 reports of metastatic tumor were included in the study. EGFR mutation status was compared with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status. Smoker status was defined as having a greater than 10 pack-year history and currently smoking cigarettes every day or most days. An ex-smoker was someone who had smoked more than 100 cigarettes in their lifetime and who does not currently smoke. A light smoker was defined as a current smoker with a less than 10 pack-year history. A never-smoker was an adult who had never smoked a cigarette or who smoked fewer than 100 cigarettes in their lifetime.

Bottom Line: We compared EGFR mutations with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status.EGFR mutation rate was significantly higher in women, never smokers, patients with adenocarcinoma, and patients who had undergone excisional biopsy.EGFR mutation rates did not differ with respect to patient age or procurement site among patients with NSCLC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Analysis of mutations in the epidermal growth factor receptor gene (EGFR) is important for predicting response to EGFR tyrosine kinase inhibitors. The overall rate of EGFR mutations in Korean patients is variable. To obtain comprehensive data on the status of EGFR mutations in Korean patients with lung cancer, the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists initiated a nationwide survey.

Methods: We obtained 1,753 reports on EGFR mutations in patients with lung cancer from 15 hospitals between January and December 2009. We compared EGFR mutations with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status.

Results: The overall EGFR mutation rate was 34.3% in patients with non-small cell lung cancer (NSCLC) and 43.3% in patients with adenocarcinoma. EGFR mutation rate was significantly higher in women, never smokers, patients with adenocarcinoma, and patients who had undergone excisional biopsy. EGFR mutation rates did not differ with respect to patient age or procurement site among patients with NSCLC.

Conclusions: EGFR mutation rates and statuses were similar to those in published data from other East Asian countries.

No MeSH data available.


Related in: MedlinePlus