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CD30-Positive T-Cell Lymphoproliferative Disease of the Oral Mucosa in Children: A Manifestation of Epstein-Barr Virus-Associated T-Lymphoproliferative Disorder.

Hong M, Ko YH - J Pathol Transl Med (2015)

Bottom Line: We report two cases in children who were initially diagnosed with EUOM and CD30(+) T-cell LPD, respectively.However, retrospective analysis revealed that a majority of infiltrated atypical T cells were positive for Epstein-Barr virus (EBV).EUOM or CD30(+) T-cell LPD in children is a manifestation of EBV-positive T-cell LPD, and should therefore be distinguished from the disease in adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT
Eosinophilic ulcer of the oral mucosa (EUOM) is a very rare, benign, self-limiting ulcerative lesion of the oral cavity of unknown pathogenesis, and belongs to the same spectrum of CD30(+) T-cell lymphoproliferative disease (LPD) of the oral mucosa. The etiology and pathogenesis of the disease are unknown. We report two cases in children who were initially diagnosed with EUOM and CD30(+) T-cell LPD, respectively. However, retrospective analysis revealed that a majority of infiltrated atypical T cells were positive for Epstein-Barr virus (EBV). The present cases suggest that the pathogenesis and etiology of EUOM or CD30(+) T-cell LPD occurring in children are different from those in adults. EUOM or CD30(+) T-cell LPD in children is a manifestation of EBV-positive T-cell LPD, and should therefore be distinguished from the disease in adults.

No MeSH data available.


Related in: MedlinePlus

Clinical finding and histopathologic findings of the oral lesion in case 1. A sharply demarcated linear ulcer was seen at the left lower gingiva (A), which was completely healed 10 days after diagnosis (B). (C) Histologically, infiltration of large atypical cells with many eosinophils was found. (D) CD3 staining highlights large T-blasts. These cells are also stained with CD30 (E) and Epstein-Barr virus (EBV) by EBV-encoded RNA in situ hybridization (F).
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f1-jptm-2015-07-13: Clinical finding and histopathologic findings of the oral lesion in case 1. A sharply demarcated linear ulcer was seen at the left lower gingiva (A), which was completely healed 10 days after diagnosis (B). (C) Histologically, infiltration of large atypical cells with many eosinophils was found. (D) CD3 staining highlights large T-blasts. These cells are also stained with CD30 (E) and Epstein-Barr virus (EBV) by EBV-encoded RNA in situ hybridization (F).

Mentions: A 13-year-old boy was referred to our hospital because of a two-week history of a painful 4 cm ulcer on his left lower gingiva. The sharply demarcated ulcer developed spontaneously without mechanical irritation. Before admission, he had suffered from recurrent stomatitis and had high fever, night sweats, and diarrhea. He was treated with antibiotics and an antipyretic, but the illness was persistent. On physical examination, he appeared acutely ill. The ulcer along the buccal gingiva was linear with a sharp erythematous margin, and was covered with a purulent exudate (Fig. 1A). He was diagnosed with EUOM before the referral, and the pathology slide was reviewed by the authors.


CD30-Positive T-Cell Lymphoproliferative Disease of the Oral Mucosa in Children: A Manifestation of Epstein-Barr Virus-Associated T-Lymphoproliferative Disorder.

Hong M, Ko YH - J Pathol Transl Med (2015)

Clinical finding and histopathologic findings of the oral lesion in case 1. A sharply demarcated linear ulcer was seen at the left lower gingiva (A), which was completely healed 10 days after diagnosis (B). (C) Histologically, infiltration of large atypical cells with many eosinophils was found. (D) CD3 staining highlights large T-blasts. These cells are also stained with CD30 (E) and Epstein-Barr virus (EBV) by EBV-encoded RNA in situ hybridization (F).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696526&req=5

f1-jptm-2015-07-13: Clinical finding and histopathologic findings of the oral lesion in case 1. A sharply demarcated linear ulcer was seen at the left lower gingiva (A), which was completely healed 10 days after diagnosis (B). (C) Histologically, infiltration of large atypical cells with many eosinophils was found. (D) CD3 staining highlights large T-blasts. These cells are also stained with CD30 (E) and Epstein-Barr virus (EBV) by EBV-encoded RNA in situ hybridization (F).
Mentions: A 13-year-old boy was referred to our hospital because of a two-week history of a painful 4 cm ulcer on his left lower gingiva. The sharply demarcated ulcer developed spontaneously without mechanical irritation. Before admission, he had suffered from recurrent stomatitis and had high fever, night sweats, and diarrhea. He was treated with antibiotics and an antipyretic, but the illness was persistent. On physical examination, he appeared acutely ill. The ulcer along the buccal gingiva was linear with a sharp erythematous margin, and was covered with a purulent exudate (Fig. 1A). He was diagnosed with EUOM before the referral, and the pathology slide was reviewed by the authors.

Bottom Line: We report two cases in children who were initially diagnosed with EUOM and CD30(+) T-cell LPD, respectively.However, retrospective analysis revealed that a majority of infiltrated atypical T cells were positive for Epstein-Barr virus (EBV).EUOM or CD30(+) T-cell LPD in children is a manifestation of EBV-positive T-cell LPD, and should therefore be distinguished from the disease in adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT
Eosinophilic ulcer of the oral mucosa (EUOM) is a very rare, benign, self-limiting ulcerative lesion of the oral cavity of unknown pathogenesis, and belongs to the same spectrum of CD30(+) T-cell lymphoproliferative disease (LPD) of the oral mucosa. The etiology and pathogenesis of the disease are unknown. We report two cases in children who were initially diagnosed with EUOM and CD30(+) T-cell LPD, respectively. However, retrospective analysis revealed that a majority of infiltrated atypical T cells were positive for Epstein-Barr virus (EBV). The present cases suggest that the pathogenesis and etiology of EUOM or CD30(+) T-cell LPD occurring in children are different from those in adults. EUOM or CD30(+) T-cell LPD in children is a manifestation of EBV-positive T-cell LPD, and should therefore be distinguished from the disease in adults.

No MeSH data available.


Related in: MedlinePlus