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Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries.

Manshian BB, Soenen SJ, Brown A, Hondow N, Wills J, Jenkins GJ, Doak SH - Mutagenesis (2015)

Bottom Line: However, our understanding of the toxicological structure-activity relationships remains limited.Carboxyl-QD demonstrated the smallest agglomerate size and greatest cellular uptake, which correlated with a dose dependent increase in cytotoxicity and genotoxicity.Oxidative stress and induced mitochondrial reactive oxygen species were only partially associated with cytotoxicity and genotoxicity induced by the QD, hence were not the only mechanisms of importance.

View Article: PubMed Central - PubMed

Affiliation: Institute of Life Science, College of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK, Biomedical NMR Unit-MoSAIC, Department of Medicine, KU Leuven, B-3000 Leuven, Belgium and.

No MeSH data available.


Related in: MedlinePlus

TEM images of test QD. (A) Carboxyl-QD, (B) amine-QD, (C) HDA-QD. All QD were prepared for imaging in their as-purchased solutions.
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Figure 1: TEM images of test QD. (A) Carboxyl-QD, (B) amine-QD, (C) HDA-QD. All QD were prepared for imaging in their as-purchased solutions.

Mentions: Assessment of primary particle characteristics was obtained by TEM imaging. The QD were analysed by drop-casting from the solutions that they were supplied in onto thin carbon films. As illustrated in Figure 1, amine-QD were generally crystalline in structure and ranged between 3 and 10nm in diameter, while carboxyl-QD were crystalline and had a diameter of 4–5nm. The HDA-QD, on the other hand, were crystalline and elliptical in shape, approximately 4nm × 8nm in dimension (Figure 1). EDX analysis demonstrated that the QD contained no impurities and only consisted of Cd, Se, Zn and S.


Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries.

Manshian BB, Soenen SJ, Brown A, Hondow N, Wills J, Jenkins GJ, Doak SH - Mutagenesis (2015)

TEM images of test QD. (A) Carboxyl-QD, (B) amine-QD, (C) HDA-QD. All QD were prepared for imaging in their as-purchased solutions.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4696518&req=5

Figure 1: TEM images of test QD. (A) Carboxyl-QD, (B) amine-QD, (C) HDA-QD. All QD were prepared for imaging in their as-purchased solutions.
Mentions: Assessment of primary particle characteristics was obtained by TEM imaging. The QD were analysed by drop-casting from the solutions that they were supplied in onto thin carbon films. As illustrated in Figure 1, amine-QD were generally crystalline in structure and ranged between 3 and 10nm in diameter, while carboxyl-QD were crystalline and had a diameter of 4–5nm. The HDA-QD, on the other hand, were crystalline and elliptical in shape, approximately 4nm × 8nm in dimension (Figure 1). EDX analysis demonstrated that the QD contained no impurities and only consisted of Cd, Se, Zn and S.

Bottom Line: However, our understanding of the toxicological structure-activity relationships remains limited.Carboxyl-QD demonstrated the smallest agglomerate size and greatest cellular uptake, which correlated with a dose dependent increase in cytotoxicity and genotoxicity.Oxidative stress and induced mitochondrial reactive oxygen species were only partially associated with cytotoxicity and genotoxicity induced by the QD, hence were not the only mechanisms of importance.

View Article: PubMed Central - PubMed

Affiliation: Institute of Life Science, College of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK, Biomedical NMR Unit-MoSAIC, Department of Medicine, KU Leuven, B-3000 Leuven, Belgium and.

No MeSH data available.


Related in: MedlinePlus