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TRANS PROF DB: A new resource for sharing translational profiles.

Spriggs RV, Willis AE - Translation (Austin) (2014)

Bottom Line: Results are provided at the level of an annotated conclusion for each gene, e.g. "Translation up-regulated", and also, where available, in a rawer form such as the normalized analyzed microarray output.We encourage all researchers to deposit their translational profiling data into TRANS PROF DB to enable us to create a truly comprehensive resource.TRANS PROF DB is available without restriction at mrctools.mrctox.le.ac.uk/TRANS_PROF_DB.

View Article: PubMed Central - PubMed

Affiliation: MRC Toxicology Unit ; Leicester, UK.

ABSTRACT
The translational efficiency of individual mRNAs can be measured on a genome-wide scale using translational profiling techniques. Data from such experiments are an enormously important resource in the quest to understand the impact of cellular state on gene expression. To improve our understanding of these data, we have created TRANS PROF DB, a manually curated resource containing the translational status of human mRNAs under defined conditions. Results are provided at the level of an annotated conclusion for each gene, e.g. "Translation up-regulated", and also, where available, in a rawer form such as the normalized analyzed microarray output. TRANS PROF DB aims to provide a central resource for the sharing of translational profiles to facilitate reuse of published data and to enable meta-analyses across data sets. As the database expands, it will provide an easily searchable archive of publicly available translational profiling data sets. We encourage all researchers to deposit their translational profiling data into TRANS PROF DB to enable us to create a truly comprehensive resource. TRANS PROF DB is available without restriction at mrctools.mrctox.le.ac.uk/TRANS_PROF_DB.

No MeSH data available.


Related in: MedlinePlus

Search, Browse and Results pages. (A) Screen shot of the Search page; the user has started typing brca2, and has selected BRCA2 from the options that appeared; the Search button can now be pressed to retrieve all BRCA2 results from the database. (B) Screen shot of the Browse page; the user has selected UVB irradiation from the available Conditions, then HeLa from the available Cell lines, then BRCA2 from the available Genes, and finally all the available Results types; Display is now available to press. (C) Screen shot of the top portion of the results page after pressing Display on the Browse page in (B) above. The conclusions and results tables are shown, together with the first few lines of the definitions of the units used. Further down the results page there are more details about the data set, including the names of the scientists responsible and links to connected papers.
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f0001: Search, Browse and Results pages. (A) Screen shot of the Search page; the user has started typing brca2, and has selected BRCA2 from the options that appeared; the Search button can now be pressed to retrieve all BRCA2 results from the database. (B) Screen shot of the Browse page; the user has selected UVB irradiation from the available Conditions, then HeLa from the available Cell lines, then BRCA2 from the available Genes, and finally all the available Results types; Display is now available to press. (C) Screen shot of the top portion of the results page after pressing Display on the Browse page in (B) above. The conclusions and results tables are shown, together with the first few lines of the definitions of the units used. Further down the results page there are more details about the data set, including the names of the scientists responsible and links to connected papers.

Mentions: As the user begins typing a gene symbol (e.g. GAPDH), a cell line (e.g. HeLa) or a condition (e.g. apoptosis) into the Search box, available matching terms in the database appear in a drop down menu (see Fig. 1A). A term is then selected and the Search button pressed; all available results and conclusions for the search term will be displayed. Example search terms are provided; clicking on an example will pre-fill the Search box. The search is case-insensitive.Figure 1.


TRANS PROF DB: A new resource for sharing translational profiles.

Spriggs RV, Willis AE - Translation (Austin) (2014)

Search, Browse and Results pages. (A) Screen shot of the Search page; the user has started typing brca2, and has selected BRCA2 from the options that appeared; the Search button can now be pressed to retrieve all BRCA2 results from the database. (B) Screen shot of the Browse page; the user has selected UVB irradiation from the available Conditions, then HeLa from the available Cell lines, then BRCA2 from the available Genes, and finally all the available Results types; Display is now available to press. (C) Screen shot of the top portion of the results page after pressing Display on the Browse page in (B) above. The conclusions and results tables are shown, together with the first few lines of the definitions of the units used. Further down the results page there are more details about the data set, including the names of the scientists responsible and links to connected papers.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696474&req=5

f0001: Search, Browse and Results pages. (A) Screen shot of the Search page; the user has started typing brca2, and has selected BRCA2 from the options that appeared; the Search button can now be pressed to retrieve all BRCA2 results from the database. (B) Screen shot of the Browse page; the user has selected UVB irradiation from the available Conditions, then HeLa from the available Cell lines, then BRCA2 from the available Genes, and finally all the available Results types; Display is now available to press. (C) Screen shot of the top portion of the results page after pressing Display on the Browse page in (B) above. The conclusions and results tables are shown, together with the first few lines of the definitions of the units used. Further down the results page there are more details about the data set, including the names of the scientists responsible and links to connected papers.
Mentions: As the user begins typing a gene symbol (e.g. GAPDH), a cell line (e.g. HeLa) or a condition (e.g. apoptosis) into the Search box, available matching terms in the database appear in a drop down menu (see Fig. 1A). A term is then selected and the Search button pressed; all available results and conclusions for the search term will be displayed. Example search terms are provided; clicking on an example will pre-fill the Search box. The search is case-insensitive.Figure 1.

Bottom Line: Results are provided at the level of an annotated conclusion for each gene, e.g. "Translation up-regulated", and also, where available, in a rawer form such as the normalized analyzed microarray output.We encourage all researchers to deposit their translational profiling data into TRANS PROF DB to enable us to create a truly comprehensive resource.TRANS PROF DB is available without restriction at mrctools.mrctox.le.ac.uk/TRANS_PROF_DB.

View Article: PubMed Central - PubMed

Affiliation: MRC Toxicology Unit ; Leicester, UK.

ABSTRACT
The translational efficiency of individual mRNAs can be measured on a genome-wide scale using translational profiling techniques. Data from such experiments are an enormously important resource in the quest to understand the impact of cellular state on gene expression. To improve our understanding of these data, we have created TRANS PROF DB, a manually curated resource containing the translational status of human mRNAs under defined conditions. Results are provided at the level of an annotated conclusion for each gene, e.g. "Translation up-regulated", and also, where available, in a rawer form such as the normalized analyzed microarray output. TRANS PROF DB aims to provide a central resource for the sharing of translational profiles to facilitate reuse of published data and to enable meta-analyses across data sets. As the database expands, it will provide an easily searchable archive of publicly available translational profiling data sets. We encourage all researchers to deposit their translational profiling data into TRANS PROF DB to enable us to create a truly comprehensive resource. TRANS PROF DB is available without restriction at mrctools.mrctox.le.ac.uk/TRANS_PROF_DB.

No MeSH data available.


Related in: MedlinePlus