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Effect of Nutrients, Dietary Supplements and Vitamins on Cognition: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Forbes SC, Holroyd-Leduc JM, Poulin MJ, Hogan DB - Can Geriatr J (2015)

Bottom Line: Observational studies have suggested that various nutrients, dietary supplements, and vitamins may delay the onset of age-associated cognitive decline and dementia.Among the other nutritional interventions, statistically significant differences between the intervention and control groups on at least one cognitive domain were found in single studies of green tea extract, Concord grape juice, chromium picolinate, beta-carotene, two different combinations of multiple vitamins, and a dietary approach developed for the control of hypertension.Omega-3 fatty acids, B vitamins, and vitamin E supplementation did not affect cognition in non-demented middle-aged and older adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, AB;

ABSTRACT

Background: Observational studies have suggested that various nutrients, dietary supplements, and vitamins may delay the onset of age-associated cognitive decline and dementia. We systematically reviewed recent randomized controlled trials investigating the effect of nutritional interventions on cognitive performance in older non-demented adults.

Methods: We searched MEDLINE, CINAHL, Embase, and the Cochrane Library for articles published between 2003 and 2013. We included randomized trials of ≥ 3 months' duration that examined the cognitive effects of a nutritional intervention in non-demented adults > 40 years of age. Meta-analyses were done when sufficient trials were available.

Results: Twenty-four trials met inclusion criteria (six omega-3 fatty acids, seven B vitamins, three vitamin E, eight other interventions). In the meta-analyses, omega-3 fatty acids showed no significant effect on Mini-Mental State Examination (MMSE) scores (four trials, mean difference 0.06, 95% CI -0.08 - 0.19) or digit span forward (three trials, mean difference -0.02, 95% CI -0.30 - 0.25), while B vitamins showed no significant effect on MMSE scores (three trials, mean difference 0.02, 95% CI -0.22 - 0.25). None of the vitamin E studies reported significant effects on cognitive outcomes. Among the other nutritional interventions, statistically significant differences between the intervention and control groups on at least one cognitive domain were found in single studies of green tea extract, Concord grape juice, chromium picolinate, beta-carotene, two different combinations of multiple vitamins, and a dietary approach developed for the control of hypertension.

Conclusions: Omega-3 fatty acids, B vitamins, and vitamin E supplementation did not affect cognition in non-demented middle-aged and older adults. Other nutritional interventions require further evaluation before their use can be advocated for the prevention of age-associated cognitive decline and dementia.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of folate, B6, and B12 studies for the outcome of Mini-Mental State Examination (MMSE) score
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f3-cgj-18-231: Meta-analysis of folate, B6, and B12 studies for the outcome of Mini-Mental State Examination (MMSE) score

Mentions: Three studies were pooled to examine the impact on MMSE scores of folate combined with vitamins B6 and/or B12 (Figure 3). The summary mean difference for MMSE scores was non-significant at 0.02 (95% CI −0.22 to 0.25, p = .90).


Effect of Nutrients, Dietary Supplements and Vitamins on Cognition: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Forbes SC, Holroyd-Leduc JM, Poulin MJ, Hogan DB - Can Geriatr J (2015)

Meta-analysis of folate, B6, and B12 studies for the outcome of Mini-Mental State Examination (MMSE) score
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696451&req=5

f3-cgj-18-231: Meta-analysis of folate, B6, and B12 studies for the outcome of Mini-Mental State Examination (MMSE) score
Mentions: Three studies were pooled to examine the impact on MMSE scores of folate combined with vitamins B6 and/or B12 (Figure 3). The summary mean difference for MMSE scores was non-significant at 0.02 (95% CI −0.22 to 0.25, p = .90).

Bottom Line: Observational studies have suggested that various nutrients, dietary supplements, and vitamins may delay the onset of age-associated cognitive decline and dementia.Among the other nutritional interventions, statistically significant differences between the intervention and control groups on at least one cognitive domain were found in single studies of green tea extract, Concord grape juice, chromium picolinate, beta-carotene, two different combinations of multiple vitamins, and a dietary approach developed for the control of hypertension.Omega-3 fatty acids, B vitamins, and vitamin E supplementation did not affect cognition in non-demented middle-aged and older adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, AB;

ABSTRACT

Background: Observational studies have suggested that various nutrients, dietary supplements, and vitamins may delay the onset of age-associated cognitive decline and dementia. We systematically reviewed recent randomized controlled trials investigating the effect of nutritional interventions on cognitive performance in older non-demented adults.

Methods: We searched MEDLINE, CINAHL, Embase, and the Cochrane Library for articles published between 2003 and 2013. We included randomized trials of ≥ 3 months' duration that examined the cognitive effects of a nutritional intervention in non-demented adults > 40 years of age. Meta-analyses were done when sufficient trials were available.

Results: Twenty-four trials met inclusion criteria (six omega-3 fatty acids, seven B vitamins, three vitamin E, eight other interventions). In the meta-analyses, omega-3 fatty acids showed no significant effect on Mini-Mental State Examination (MMSE) scores (four trials, mean difference 0.06, 95% CI -0.08 - 0.19) or digit span forward (three trials, mean difference -0.02, 95% CI -0.30 - 0.25), while B vitamins showed no significant effect on MMSE scores (three trials, mean difference 0.02, 95% CI -0.22 - 0.25). None of the vitamin E studies reported significant effects on cognitive outcomes. Among the other nutritional interventions, statistically significant differences between the intervention and control groups on at least one cognitive domain were found in single studies of green tea extract, Concord grape juice, chromium picolinate, beta-carotene, two different combinations of multiple vitamins, and a dietary approach developed for the control of hypertension.

Conclusions: Omega-3 fatty acids, B vitamins, and vitamin E supplementation did not affect cognition in non-demented middle-aged and older adults. Other nutritional interventions require further evaluation before their use can be advocated for the prevention of age-associated cognitive decline and dementia.

No MeSH data available.


Related in: MedlinePlus