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The effect of glutamine intake on complications of colorectal and colon cancer treatment: A systematic review.

Jolfaie NR, Mirzaie S, Ghiasvand R, Askari G, Miraghajani M - J Res Med Sci (2015)

Bottom Line: It has been reported that some dietary components such as glutamine (Gln) have beneficial effects on these complications of cancer therapies.However, the results of studies are inconsistent in this area.The results of the present review suggested that Gln intake among colon and colorectal cancer patients could reduce some complications induced by chemotherapy such as gut mucositis and diarrhea and improve nitrogen balance, immune system and wound healing after surgery, whereas benefits role of Gln on radiochemotherapy side effects were not provided.

View Article: PubMed Central - PubMed

Affiliation: Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Improvement in complications of antitumor agents and surgery is important to enhance life quality and survival among patients with colon and colorectal cancer. It has been reported that some dietary components such as glutamine (Gln) have beneficial effects on these complications of cancer therapies. However, the results of studies are inconsistent in this area. We performed a review on randomized controlled trials (RCTs) evaluating the effects of Gln intake on complications related to therapeutic strategies of the colon and colorectal cancer.

Materials and methods: A systematic search was conducted in PubMed, Google Scholar, Cochrane Library, and SID databases to find the relevant literature, published before July 2015.

Results: Nine RCTs of 217 screened articles were included in this systematic review. The results of the present review suggested that Gln intake among colon and colorectal cancer patients could reduce some complications induced by chemotherapy such as gut mucositis and diarrhea and improve nitrogen balance, immune system and wound healing after surgery, whereas benefits role of Gln on radiochemotherapy side effects were not provided.

Conclusion: The role of Gln intake on some improvement of complications induced by cancer therapeutic methods and shorten the length of hospital stay may be promising and one that is worthy of further exploration.

No MeSH data available.


Related in: MedlinePlus

Flow chart of systematic literature search
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Figure 1: Flow chart of systematic literature search

Mentions: Detailed processes of the study selection were illustrated in Figure 1. Generally, 217 kinds of literature were identified via the initial electronic search; 8 of them were selected according to inclusion and exclusion criteria and 1 paper was added to hand search. These articles had a parallel design and were from the Asian and European countries. The average of intervention period was 5 days. The number of participants varied from 12 to 109 subjects and the mean age was 60 years. Table 1 provides a summary of the study characteristics included in this systematic review. These studies were classified into the three groups: Effects of Gln intervention in colon or colorectal cancer patients under chemotherapy (n = 4), radiochemotherapy (n = 1) and under surgery (n = 4).


The effect of glutamine intake on complications of colorectal and colon cancer treatment: A systematic review.

Jolfaie NR, Mirzaie S, Ghiasvand R, Askari G, Miraghajani M - J Res Med Sci (2015)

Flow chart of systematic literature search
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696378&req=5

Figure 1: Flow chart of systematic literature search
Mentions: Detailed processes of the study selection were illustrated in Figure 1. Generally, 217 kinds of literature were identified via the initial electronic search; 8 of them were selected according to inclusion and exclusion criteria and 1 paper was added to hand search. These articles had a parallel design and were from the Asian and European countries. The average of intervention period was 5 days. The number of participants varied from 12 to 109 subjects and the mean age was 60 years. Table 1 provides a summary of the study characteristics included in this systematic review. These studies were classified into the three groups: Effects of Gln intervention in colon or colorectal cancer patients under chemotherapy (n = 4), radiochemotherapy (n = 1) and under surgery (n = 4).

Bottom Line: It has been reported that some dietary components such as glutamine (Gln) have beneficial effects on these complications of cancer therapies.However, the results of studies are inconsistent in this area.The results of the present review suggested that Gln intake among colon and colorectal cancer patients could reduce some complications induced by chemotherapy such as gut mucositis and diarrhea and improve nitrogen balance, immune system and wound healing after surgery, whereas benefits role of Gln on radiochemotherapy side effects were not provided.

View Article: PubMed Central - PubMed

Affiliation: Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Improvement in complications of antitumor agents and surgery is important to enhance life quality and survival among patients with colon and colorectal cancer. It has been reported that some dietary components such as glutamine (Gln) have beneficial effects on these complications of cancer therapies. However, the results of studies are inconsistent in this area. We performed a review on randomized controlled trials (RCTs) evaluating the effects of Gln intake on complications related to therapeutic strategies of the colon and colorectal cancer.

Materials and methods: A systematic search was conducted in PubMed, Google Scholar, Cochrane Library, and SID databases to find the relevant literature, published before July 2015.

Results: Nine RCTs of 217 screened articles were included in this systematic review. The results of the present review suggested that Gln intake among colon and colorectal cancer patients could reduce some complications induced by chemotherapy such as gut mucositis and diarrhea and improve nitrogen balance, immune system and wound healing after surgery, whereas benefits role of Gln on radiochemotherapy side effects were not provided.

Conclusion: The role of Gln intake on some improvement of complications induced by cancer therapeutic methods and shorten the length of hospital stay may be promising and one that is worthy of further exploration.

No MeSH data available.


Related in: MedlinePlus