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Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial.

Kafeshani M, Janghorbani M, Salehi R, Kazemi M, Entezari MH - J Res Med Sci (2015)

Bottom Line: Independent sample t-test and paired-samples t-test were used to compare means of all variables within and between two groups respectively.Weight and waist circumference decreased in DASH group significantly compared to the UDA group (P < 0.05) but the results between the two groups showed no significant difference.DASH diet increased IRS1 gene expression and probably has beneficial effects on IR risks.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Nutrition/Community Nutrition/Food Science & Technology, Food Security Research Center, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Insulin receptor substrate (IRS) Type 1 is a main substrate for the insulin receptor, controls insulin signaling in skeletal muscle, adipose tissue, and the vascular, so it is an important candidate gene for insulin resistance (IR). We aimed to compare the effects of the Dietary Approaches to Stop Hypertension (DASH) and Usual Dietary Advices (UDA) on IRS1 gene expression in women at risk for cardiovascular disease.

Materials and methods: A randomized controlled clinical trial was performed in 44 women at risk for cardiovascular disease. Participants were randomly assigned to a UDA diet or the DASH diet. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fat, total fat, cholesterol, refined grains, and sweets, with a total of 2400 mg/day sodium. The UDA diet was a regular diet with healthy dietary advice. Gene expression was assessed by the real-time polymerase chain reaction at the first of study and after 12 weeks. Independent sample t-test and paired-samples t-test were used to compare means of all variables within and between two groups respectively.

Results: IRS1 gene expression was increased in DASH group compared with UDA diet (P = 0.00). Weight and waist circumference decreased in DASH group significantly compared to the UDA group (P < 0.05) but the results between the two groups showed no significant difference.

Conclusion: DASH diet increased IRS1 gene expression and probably has beneficial effects on IR risks.

No MeSH data available.


Related in: MedlinePlus

Consort diagram template
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Figure 1: Consort diagram template

Mentions: Of the 51 participants, 44 persons completed the study. During the study, one patient was diagnosed with polycystic syndrome and another with high weight change, so these two patients had to be excluded from the analyses. Five patients deviated from the study protocol and therefore, their data were not available. Consort diagram is shown in Figure 1. Differences in distribution of several characteristics among 22 individuals in DASH group and 22 subjects within the UDA group are shown in Table 3. The mean patient age was 38 ± 8 years in UDA group and 37 ± 9 years in the intervention group. There was no difference between groups regarding age, socioeconomic status, weight, PA, and gene expression at the baseline.


Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial.

Kafeshani M, Janghorbani M, Salehi R, Kazemi M, Entezari MH - J Res Med Sci (2015)

Consort diagram template
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4696366&req=5

Figure 1: Consort diagram template
Mentions: Of the 51 participants, 44 persons completed the study. During the study, one patient was diagnosed with polycystic syndrome and another with high weight change, so these two patients had to be excluded from the analyses. Five patients deviated from the study protocol and therefore, their data were not available. Consort diagram is shown in Figure 1. Differences in distribution of several characteristics among 22 individuals in DASH group and 22 subjects within the UDA group are shown in Table 3. The mean patient age was 38 ± 8 years in UDA group and 37 ± 9 years in the intervention group. There was no difference between groups regarding age, socioeconomic status, weight, PA, and gene expression at the baseline.

Bottom Line: Independent sample t-test and paired-samples t-test were used to compare means of all variables within and between two groups respectively.Weight and waist circumference decreased in DASH group significantly compared to the UDA group (P < 0.05) but the results between the two groups showed no significant difference.DASH diet increased IRS1 gene expression and probably has beneficial effects on IR risks.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Nutrition/Community Nutrition/Food Science & Technology, Food Security Research Center, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Insulin receptor substrate (IRS) Type 1 is a main substrate for the insulin receptor, controls insulin signaling in skeletal muscle, adipose tissue, and the vascular, so it is an important candidate gene for insulin resistance (IR). We aimed to compare the effects of the Dietary Approaches to Stop Hypertension (DASH) and Usual Dietary Advices (UDA) on IRS1 gene expression in women at risk for cardiovascular disease.

Materials and methods: A randomized controlled clinical trial was performed in 44 women at risk for cardiovascular disease. Participants were randomly assigned to a UDA diet or the DASH diet. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fat, total fat, cholesterol, refined grains, and sweets, with a total of 2400 mg/day sodium. The UDA diet was a regular diet with healthy dietary advice. Gene expression was assessed by the real-time polymerase chain reaction at the first of study and after 12 weeks. Independent sample t-test and paired-samples t-test were used to compare means of all variables within and between two groups respectively.

Results: IRS1 gene expression was increased in DASH group compared with UDA diet (P = 0.00). Weight and waist circumference decreased in DASH group significantly compared to the UDA group (P < 0.05) but the results between the two groups showed no significant difference.

Conclusion: DASH diet increased IRS1 gene expression and probably has beneficial effects on IR risks.

No MeSH data available.


Related in: MedlinePlus