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Conversion of mild cognitive impairment patients in Alzheimer's disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio.

Moretti DV - Alzheimers Res Ther (2015)

Bottom Line: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex.High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe.Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects.

View Article: PubMed Central - PubMed

Affiliation: Alzheimer' Disease Rehabilitation Unit, IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. davide.moretti@afar.it.

ABSTRACT

Introduction: The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer's disease (AD).

Methods: Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has been evaluated after a three years follow-up. Twenty-seven of these subjects underwent perfusion single-photon emission computed tomography (SPECT) evaluation also. Increasing alpha3/alpha2 power ratio, was computed for each subject. Differences in EEG markers, cortical thickness, brain perfusion among the groups were estimated.

Results: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex. After a follow-up of three years, these patients converted in AD.

Conclusion: High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe. Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in the clinical context.

No MeSH data available.


Related in: MedlinePlus

ANOVA results of theta/gamma and alpha3/alpha2 relative power ratio. In the graph post-hoc results are shown (see text for details). ANOVA analysis of variance
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Fig4: ANOVA results of theta/gamma and alpha3/alpha2 relative power ratio. In the graph post-hoc results are shown (see text for details). ANOVA analysis of variance

Mentions: Figure 4 showed ANOVA significant statistical difference of theta/gamma and alpha3/alpha2 relative power ratio (F2,73 = 3.70; p < 0.03 and F2,73 = 4.46; p < 0.02, respectively). Duncan’s post-hoc test showed a significant increase (p < 0.01) of theta/gamma in both the MCI converters group with respect to non-converters as well as a significant increase of alpha3/alpha2 ratio in the MCI-AD converters with respect to the other groups (p < 0.02). In order to strengthen the results, the analysis was repeated also covarying the hippocampal volume and neuropsychological tests (NPS) scores. Significant results were confirmed for both theta/gamma (F2,73 = 2.49; p < 0.05) and alpha3/alpha2 ratio (F2,73 = 3.15; p < 0.04).Fig. 4


Conversion of mild cognitive impairment patients in Alzheimer's disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio.

Moretti DV - Alzheimers Res Ther (2015)

ANOVA results of theta/gamma and alpha3/alpha2 relative power ratio. In the graph post-hoc results are shown (see text for details). ANOVA analysis of variance
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4696332&req=5

Fig4: ANOVA results of theta/gamma and alpha3/alpha2 relative power ratio. In the graph post-hoc results are shown (see text for details). ANOVA analysis of variance
Mentions: Figure 4 showed ANOVA significant statistical difference of theta/gamma and alpha3/alpha2 relative power ratio (F2,73 = 3.70; p < 0.03 and F2,73 = 4.46; p < 0.02, respectively). Duncan’s post-hoc test showed a significant increase (p < 0.01) of theta/gamma in both the MCI converters group with respect to non-converters as well as a significant increase of alpha3/alpha2 ratio in the MCI-AD converters with respect to the other groups (p < 0.02). In order to strengthen the results, the analysis was repeated also covarying the hippocampal volume and neuropsychological tests (NPS) scores. Significant results were confirmed for both theta/gamma (F2,73 = 2.49; p < 0.05) and alpha3/alpha2 ratio (F2,73 = 3.15; p < 0.04).Fig. 4

Bottom Line: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex.High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe.Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects.

View Article: PubMed Central - PubMed

Affiliation: Alzheimer' Disease Rehabilitation Unit, IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. davide.moretti@afar.it.

ABSTRACT

Introduction: The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer's disease (AD).

Methods: Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has been evaluated after a three years follow-up. Twenty-seven of these subjects underwent perfusion single-photon emission computed tomography (SPECT) evaluation also. Increasing alpha3/alpha2 power ratio, was computed for each subject. Differences in EEG markers, cortical thickness, brain perfusion among the groups were estimated.

Results: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex. After a follow-up of three years, these patients converted in AD.

Conclusion: High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe. Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in the clinical context.

No MeSH data available.


Related in: MedlinePlus