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Conversion of mild cognitive impairment patients in Alzheimer's disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio.

Moretti DV - Alzheimers Res Ther (2015)

Bottom Line: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex.High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe.Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects.

View Article: PubMed Central - PubMed

Affiliation: Alzheimer' Disease Rehabilitation Unit, IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. davide.moretti@afar.it.

ABSTRACT

Introduction: The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer's disease (AD).

Methods: Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has been evaluated after a three years follow-up. Twenty-seven of these subjects underwent perfusion single-photon emission computed tomography (SPECT) evaluation also. Increasing alpha3/alpha2 power ratio, was computed for each subject. Differences in EEG markers, cortical thickness, brain perfusion among the groups were estimated.

Results: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex. After a follow-up of three years, these patients converted in AD.

Conclusion: High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe. Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in the clinical context.

No MeSH data available.


Related in: MedlinePlus

SPECT visual rating. The output shows a SPECT visual inspection of glucose uptake metabolism: the black square denotes an area of mild-to-moderate temporo-parietal hypometabolism in one of the 14 low risk MCI patients and in one of the 13 high risk MCI patients respective to one of the 17 enrolled controls. SPECT single-photon emission computed tomography, MCI mild cognitive impairment
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Fig3: SPECT visual rating. The output shows a SPECT visual inspection of glucose uptake metabolism: the black square denotes an area of mild-to-moderate temporo-parietal hypometabolism in one of the 14 low risk MCI patients and in one of the 13 high risk MCI patients respective to one of the 17 enrolled controls. SPECT single-photon emission computed tomography, MCI mild cognitive impairment

Mentions: Babcock Test: In the high alpha3/alpha2 group, a significant positive correlation was found between logical memory performance in the Babcock test and thickness values in the left caudal middle frontal cortex (cluster size = 36 mm2; stereotaxic coordinate x, y, z = −34 22 47; r = 0.80; p = 0.0001) and left inferior temporal cortex (15 mm2; −54 -28 -26; r =072; p =0001), and right rostral middle frontal cortex (28 mm2; 23 56–13; r = 0.74; p = 0.00) (Fig. 3). No significant correlation was found within the same regions nor in the other groups nor in the whole sample. 2) AVLT immediate recall: In the high alpha3/alpha2 group, memory performance was significantly correlated with the cortical thickness values in the precuneus bilaterally (left 47 mm2; −21 -61 ; r = 0.78 < 0.000, right 58 m2; 20–60 25; r = 0.72 = 0.007, left fusiform cortex (40 mm2; −41 -25 -21; r = 0.76; p = 0005), inferior infertile parietal 43 mm2 -46 -60 11; r = 0.74; p = 0.0001), inferior temporal cortex (35 mm2; 21; r = 0.71; p = 0.0008), and the right bank of the superior temporal sulcus (44 m8 9; r = < 0.000). Memory performance was correlated in the middle group with both the right precuneus cortex (r = 0 = 0.03), and banks of the superior temporal sulcus (r = 0..02). No other associations were found in either the low group or in the entire sample.Fig. 3


Conversion of mild cognitive impairment patients in Alzheimer's disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio.

Moretti DV - Alzheimers Res Ther (2015)

SPECT visual rating. The output shows a SPECT visual inspection of glucose uptake metabolism: the black square denotes an area of mild-to-moderate temporo-parietal hypometabolism in one of the 14 low risk MCI patients and in one of the 13 high risk MCI patients respective to one of the 17 enrolled controls. SPECT single-photon emission computed tomography, MCI mild cognitive impairment
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4696332&req=5

Fig3: SPECT visual rating. The output shows a SPECT visual inspection of glucose uptake metabolism: the black square denotes an area of mild-to-moderate temporo-parietal hypometabolism in one of the 14 low risk MCI patients and in one of the 13 high risk MCI patients respective to one of the 17 enrolled controls. SPECT single-photon emission computed tomography, MCI mild cognitive impairment
Mentions: Babcock Test: In the high alpha3/alpha2 group, a significant positive correlation was found between logical memory performance in the Babcock test and thickness values in the left caudal middle frontal cortex (cluster size = 36 mm2; stereotaxic coordinate x, y, z = −34 22 47; r = 0.80; p = 0.0001) and left inferior temporal cortex (15 mm2; −54 -28 -26; r =072; p =0001), and right rostral middle frontal cortex (28 mm2; 23 56–13; r = 0.74; p = 0.00) (Fig. 3). No significant correlation was found within the same regions nor in the other groups nor in the whole sample. 2) AVLT immediate recall: In the high alpha3/alpha2 group, memory performance was significantly correlated with the cortical thickness values in the precuneus bilaterally (left 47 mm2; −21 -61 ; r = 0.78 < 0.000, right 58 m2; 20–60 25; r = 0.72 = 0.007, left fusiform cortex (40 mm2; −41 -25 -21; r = 0.76; p = 0005), inferior infertile parietal 43 mm2 -46 -60 11; r = 0.74; p = 0.0001), inferior temporal cortex (35 mm2; 21; r = 0.71; p = 0.0008), and the right bank of the superior temporal sulcus (44 m8 9; r = < 0.000). Memory performance was correlated in the middle group with both the right precuneus cortex (r = 0 = 0.03), and banks of the superior temporal sulcus (r = 0..02). No other associations were found in either the low group or in the entire sample.Fig. 3

Bottom Line: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex.High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe.Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects.

View Article: PubMed Central - PubMed

Affiliation: Alzheimer' Disease Rehabilitation Unit, IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. davide.moretti@afar.it.

ABSTRACT

Introduction: The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer's disease (AD).

Methods: Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has been evaluated after a three years follow-up. Twenty-seven of these subjects underwent perfusion single-photon emission computed tomography (SPECT) evaluation also. Increasing alpha3/alpha2 power ratio, was computed for each subject. Differences in EEG markers, cortical thickness, brain perfusion among the groups were estimated.

Results: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex. After a follow-up of three years, these patients converted in AD.

Conclusion: High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe. Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in the clinical context.

No MeSH data available.


Related in: MedlinePlus