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Conversion of mild cognitive impairment patients in Alzheimer's disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio.

Moretti DV - Alzheimers Res Ther (2015)

Bottom Line: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex.High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe.Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects.

View Article: PubMed Central - PubMed

Affiliation: Alzheimer' Disease Rehabilitation Unit, IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. davide.moretti@afar.it.

ABSTRACT

Introduction: The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer's disease (AD).

Methods: Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has been evaluated after a three years follow-up. Twenty-seven of these subjects underwent perfusion single-photon emission computed tomography (SPECT) evaluation also. Increasing alpha3/alpha2 power ratio, was computed for each subject. Differences in EEG markers, cortical thickness, brain perfusion among the groups were estimated.

Results: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex. After a follow-up of three years, these patients converted in AD.

Conclusion: High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe. Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in the clinical context.

No MeSH data available.


Related in: MedlinePlus

In red are represented the brain regions with higher regional cortical thickness in MCI patients with high a3/a2 ratio as compared to MCI patients with low a3/a2 ratio (p < 0.01 uncorrected). The color-coding for p values is on a logarithmic scale. Results are presented on the pial cortical surface of the brain: dark gray regions represent sulci and light gray regions represent gyri. MCI mild cognitive impairment
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Fig1: In red are represented the brain regions with higher regional cortical thickness in MCI patients with high a3/a2 ratio as compared to MCI patients with low a3/a2 ratio (p < 0.01 uncorrected). The color-coding for p values is on a logarithmic scale. Results are presented on the pial cortical surface of the brain: dark gray regions represent sulci and light gray regions represent gyri. MCI mild cognitive impairment

Mentions: High vs Low: When compared to subjects with low a3/a2 ratios, patients with high a3/a2 ratio show thinning of the bilateral superior temporal, supramarginal, and precuneus cortices, in the right inferior parietal cortex and insular cortex. The total cortical gray matter (CGM) reduction in the high a3/a2 group compared to the low a3/a2 group was 471 mm2 (Fig. 1).Fig. 1


Conversion of mild cognitive impairment patients in Alzheimer's disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio.

Moretti DV - Alzheimers Res Ther (2015)

In red are represented the brain regions with higher regional cortical thickness in MCI patients with high a3/a2 ratio as compared to MCI patients with low a3/a2 ratio (p < 0.01 uncorrected). The color-coding for p values is on a logarithmic scale. Results are presented on the pial cortical surface of the brain: dark gray regions represent sulci and light gray regions represent gyri. MCI mild cognitive impairment
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4696332&req=5

Fig1: In red are represented the brain regions with higher regional cortical thickness in MCI patients with high a3/a2 ratio as compared to MCI patients with low a3/a2 ratio (p < 0.01 uncorrected). The color-coding for p values is on a logarithmic scale. Results are presented on the pial cortical surface of the brain: dark gray regions represent sulci and light gray regions represent gyri. MCI mild cognitive impairment
Mentions: High vs Low: When compared to subjects with low a3/a2 ratios, patients with high a3/a2 ratio show thinning of the bilateral superior temporal, supramarginal, and precuneus cortices, in the right inferior parietal cortex and insular cortex. The total cortical gray matter (CGM) reduction in the high a3/a2 group compared to the low a3/a2 group was 471 mm2 (Fig. 1).Fig. 1

Bottom Line: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex.High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe.Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects.

View Article: PubMed Central - PubMed

Affiliation: Alzheimer' Disease Rehabilitation Unit, IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. davide.moretti@afar.it.

ABSTRACT

Introduction: The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer's disease (AD).

Methods: Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has been evaluated after a three years follow-up. Twenty-seven of these subjects underwent perfusion single-photon emission computed tomography (SPECT) evaluation also. Increasing alpha3/alpha2 power ratio, was computed for each subject. Differences in EEG markers, cortical thickness, brain perfusion among the groups were estimated.

Results: In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex. After a follow-up of three years, these patients converted in AD.

Conclusion: High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe. Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in the clinical context.

No MeSH data available.


Related in: MedlinePlus