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Relapse of choroidal neovascularization in Bietti's crystalline retinopathy following anti-vascular endothelial growth factor therapy: A case report.

Hua R, Chen K, Hu Y, Wang X, Chen L - Exp Ther Med (2015)

Bottom Line: Bevacizumab was injected once intravitreally.The 3-month follow-up included visualization of the lesion's regression with spectral domain optical coherence tomography (SD-OCT).However, at 3 months after the injection, the CNV reoccurred.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

ABSTRACT

Choroidal neovascularization secondary to retinitis pigmentosa is rarely observed in clinical practice. The present study describes a case of atypical retinitis pigmentosa, crystalline retinal pigmentary degeneration, complicated by choroidal neovascularization (CNV) in a 26-year-old man presenting with blurred vision in the right eye. Heidelberg multimodality imaging was performed to achieve a confirmed diagnosis. Bevacizumab was injected once intravitreally. The 3-month follow-up included visualization of the lesion's regression with spectral domain optical coherence tomography (SD-OCT). However, at 3 months after the injection, the CNV reoccurred. To the best of our knowledge, this is the first time that a case of CNV secondary to retinitis pigmentosa, in which the diagnosis was confirmed via multimodality imaging and the therapeutic efficacy was evaluated by SD-OCT, has been reported in China.

No MeSH data available.


Related in: MedlinePlus

(A) Fundus photographs of choroidal neovascularization occurrence in the right eye. Foveal subretinal hemorrhage (green arrow) was observed (B) 6 days after the first visit of the patient and was completely absorbed (C) 1 month later. (D) Yellow-white exudates were observed 3 months later (red arrow). Compared with (E) indocyanine green angiography, the hot-spot apparent in (F) fluorescein angiography (the green arrow represents the OCT direction) was verified by (G) OCT (green line). The changes in the photoreceptors and (H) retinal pigment epithelium (red arrow) are shown. OCT, optical coherence tomography.
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f1-etm-0-0-2716: (A) Fundus photographs of choroidal neovascularization occurrence in the right eye. Foveal subretinal hemorrhage (green arrow) was observed (B) 6 days after the first visit of the patient and was completely absorbed (C) 1 month later. (D) Yellow-white exudates were observed 3 months later (red arrow). Compared with (E) indocyanine green angiography, the hot-spot apparent in (F) fluorescein angiography (the green arrow represents the OCT direction) was verified by (G) OCT (green line). The changes in the photoreceptors and (H) retinal pigment epithelium (red arrow) are shown. OCT, optical coherence tomography.

Mentions: The patient was admitted to First Hospital of China Medical University (Shenyang, China) on October 1, 2011, with no prior medical history. Informed consent was obtained from the patient. A 26-year-old man complained of blurred vision in the right eye for 2 months, with night blindness in the left and right eyes since late childhood. The patient's best-corrected visual acuity (BCVA) was 36/60 in the right eye and 60/60 in the left eye. The fundus examination revealed marked, widely distributed, crystalline degeneration in both eyes, without bony spicules. Six days after the patient's visit, foveal subretinal hemorrhage appeared in the right eye (Fig. 1). The visual field results showed impaired peripheral vision in both eyes. Afterwards, a diagnosis of BCR was determined based on the description of BCR characteristics in Chinese patients (8).


Relapse of choroidal neovascularization in Bietti's crystalline retinopathy following anti-vascular endothelial growth factor therapy: A case report.

Hua R, Chen K, Hu Y, Wang X, Chen L - Exp Ther Med (2015)

(A) Fundus photographs of choroidal neovascularization occurrence in the right eye. Foveal subretinal hemorrhage (green arrow) was observed (B) 6 days after the first visit of the patient and was completely absorbed (C) 1 month later. (D) Yellow-white exudates were observed 3 months later (red arrow). Compared with (E) indocyanine green angiography, the hot-spot apparent in (F) fluorescein angiography (the green arrow represents the OCT direction) was verified by (G) OCT (green line). The changes in the photoreceptors and (H) retinal pigment epithelium (red arrow) are shown. OCT, optical coherence tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4665965&req=5

f1-etm-0-0-2716: (A) Fundus photographs of choroidal neovascularization occurrence in the right eye. Foveal subretinal hemorrhage (green arrow) was observed (B) 6 days after the first visit of the patient and was completely absorbed (C) 1 month later. (D) Yellow-white exudates were observed 3 months later (red arrow). Compared with (E) indocyanine green angiography, the hot-spot apparent in (F) fluorescein angiography (the green arrow represents the OCT direction) was verified by (G) OCT (green line). The changes in the photoreceptors and (H) retinal pigment epithelium (red arrow) are shown. OCT, optical coherence tomography.
Mentions: The patient was admitted to First Hospital of China Medical University (Shenyang, China) on October 1, 2011, with no prior medical history. Informed consent was obtained from the patient. A 26-year-old man complained of blurred vision in the right eye for 2 months, with night blindness in the left and right eyes since late childhood. The patient's best-corrected visual acuity (BCVA) was 36/60 in the right eye and 60/60 in the left eye. The fundus examination revealed marked, widely distributed, crystalline degeneration in both eyes, without bony spicules. Six days after the patient's visit, foveal subretinal hemorrhage appeared in the right eye (Fig. 1). The visual field results showed impaired peripheral vision in both eyes. Afterwards, a diagnosis of BCR was determined based on the description of BCR characteristics in Chinese patients (8).

Bottom Line: Bevacizumab was injected once intravitreally.The 3-month follow-up included visualization of the lesion's regression with spectral domain optical coherence tomography (SD-OCT).However, at 3 months after the injection, the CNV reoccurred.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

ABSTRACT

Choroidal neovascularization secondary to retinitis pigmentosa is rarely observed in clinical practice. The present study describes a case of atypical retinitis pigmentosa, crystalline retinal pigmentary degeneration, complicated by choroidal neovascularization (CNV) in a 26-year-old man presenting with blurred vision in the right eye. Heidelberg multimodality imaging was performed to achieve a confirmed diagnosis. Bevacizumab was injected once intravitreally. The 3-month follow-up included visualization of the lesion's regression with spectral domain optical coherence tomography (SD-OCT). However, at 3 months after the injection, the CNV reoccurred. To the best of our knowledge, this is the first time that a case of CNV secondary to retinitis pigmentosa, in which the diagnosis was confirmed via multimodality imaging and the therapeutic efficacy was evaluated by SD-OCT, has been reported in China.

No MeSH data available.


Related in: MedlinePlus