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Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus

Mean ± SD (n = 59 participants) intra- and inter-individual Coefficient of Variation (CV) of the PIPR metrics with blue light; red light showed similar results (not shown).
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f8: Mean ± SD (n = 59 participants) intra- and inter-individual Coefficient of Variation (CV) of the PIPR metrics with blue light; red light showed similar results (not shown).

Mentions: To consider the variability of the PIPR metrics, the intra- and inter-individual Coefficient of Variation (CV) was calculated (Fig. 8). The intra-individual CV significantly differed among the four PIPR metrics (One-Way ANOVA: F3,196 = 41.45, P < 0.001). Post-hoc analysis indicated that the intra-individual CV for the 6 s and plateau metrics was significantly different to the AUC metrics, with a lower variation for the 6 s and plateau metrics compared to the AUC metrics (Fig. 8). Similarly, inter-individual CV was lower for the 6 s and plateau metrics compared to the AUC metrics.


Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Mean ± SD (n = 59 participants) intra- and inter-individual Coefficient of Variation (CV) of the PIPR metrics with blue light; red light showed similar results (not shown).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664956&req=5

f8: Mean ± SD (n = 59 participants) intra- and inter-individual Coefficient of Variation (CV) of the PIPR metrics with blue light; red light showed similar results (not shown).
Mentions: To consider the variability of the PIPR metrics, the intra- and inter-individual Coefficient of Variation (CV) was calculated (Fig. 8). The intra-individual CV significantly differed among the four PIPR metrics (One-Way ANOVA: F3,196 = 41.45, P < 0.001). Post-hoc analysis indicated that the intra-individual CV for the 6 s and plateau metrics was significantly different to the AUC metrics, with a lower variation for the 6 s and plateau metrics compared to the AUC metrics (Fig. 8). Similarly, inter-individual CV was lower for the 6 s and plateau metrics compared to the AUC metrics.

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus