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Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus

Relationship between the baseline pupil diameter (mm) and age (Panel (A)) and the 6 s PIPR (Panel (B)) (n = 59 participants).The 6 s PIPR is given in mm (not % baseline as in the other figures) and a larger value indicates a larger PIPR. The F-values indicate the slopes of the regression lines are significantly different from zero.
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f6: Relationship between the baseline pupil diameter (mm) and age (Panel (A)) and the 6 s PIPR (Panel (B)) (n = 59 participants).The 6 s PIPR is given in mm (not % baseline as in the other figures) and a larger value indicates a larger PIPR. The F-values indicate the slopes of the regression lines are significantly different from zero.

Mentions: The baseline pupil diameter (BPD) measured in the dark decreases significantly with age in agreement with previous studies (Fig. 6A)173536. The BPD decreases during ageing by 0.045 mm per year, similar to a previously reported reduction rate of 0.043 mm per year36. We further confirm a previous report17 that the PIPR amplitude with blue lights increases significantly with increasing BPD (r2 = 0.130, P = 0.01), validating the use of percentage (%) BPD to describe the PLR and PIPR metrics (Fig. 6B).


Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Relationship between the baseline pupil diameter (mm) and age (Panel (A)) and the 6 s PIPR (Panel (B)) (n = 59 participants).The 6 s PIPR is given in mm (not % baseline as in the other figures) and a larger value indicates a larger PIPR. The F-values indicate the slopes of the regression lines are significantly different from zero.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664956&req=5

f6: Relationship between the baseline pupil diameter (mm) and age (Panel (A)) and the 6 s PIPR (Panel (B)) (n = 59 participants).The 6 s PIPR is given in mm (not % baseline as in the other figures) and a larger value indicates a larger PIPR. The F-values indicate the slopes of the regression lines are significantly different from zero.
Mentions: The baseline pupil diameter (BPD) measured in the dark decreases significantly with age in agreement with previous studies (Fig. 6A)173536. The BPD decreases during ageing by 0.045 mm per year, similar to a previously reported reduction rate of 0.043 mm per year36. We further confirm a previous report17 that the PIPR amplitude with blue lights increases significantly with increasing BPD (r2 = 0.130, P = 0.01), validating the use of percentage (%) BPD to describe the PLR and PIPR metrics (Fig. 6B).

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus