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Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus

Relationship between age and the transient PLR (upper panels) and peak pupil constriction (lower panels) (n = 59 participants).The red and blue circles indicate the response with red and blue lights, respectively; and the solid lines show the best-fitting linear regressions. The F-values indicate the slopes of the regression lines do not change as a function of age.
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f4: Relationship between age and the transient PLR (upper panels) and peak pupil constriction (lower panels) (n = 59 participants).The red and blue circles indicate the response with red and blue lights, respectively; and the solid lines show the best-fitting linear regressions. The F-values indicate the slopes of the regression lines do not change as a function of age.

Mentions: During light stimulation, the slopes of the regression lines describing the transient PLR and peak pupil constriction data were not significantly different from zero for red and blue lights indicating that these metrics are independent of age (Fig. 4). We determined the relationship between age and the Post-Illumination Pupil Response (PIPR) for four PIPR metrics (Fig. 5). Blue pulses produced a significantly larger 6 s PIPR amplitude than red pulses (Paired t-test: t(57) = 20.07, P < 0.001) due to the higher melanopsin excitation with the short wavelength (blue) light. The slopes of the regression lines were not significantly different from zero for any PIPR metric indicating the PIPR amplitude is independent of age.


Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Relationship between age and the transient PLR (upper panels) and peak pupil constriction (lower panels) (n = 59 participants).The red and blue circles indicate the response with red and blue lights, respectively; and the solid lines show the best-fitting linear regressions. The F-values indicate the slopes of the regression lines do not change as a function of age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664956&req=5

f4: Relationship between age and the transient PLR (upper panels) and peak pupil constriction (lower panels) (n = 59 participants).The red and blue circles indicate the response with red and blue lights, respectively; and the solid lines show the best-fitting linear regressions. The F-values indicate the slopes of the regression lines do not change as a function of age.
Mentions: During light stimulation, the slopes of the regression lines describing the transient PLR and peak pupil constriction data were not significantly different from zero for red and blue lights indicating that these metrics are independent of age (Fig. 4). We determined the relationship between age and the Post-Illumination Pupil Response (PIPR) for four PIPR metrics (Fig. 5). Blue pulses produced a significantly larger 6 s PIPR amplitude than red pulses (Paired t-test: t(57) = 20.07, P < 0.001) due to the higher melanopsin excitation with the short wavelength (blue) light. The slopes of the regression lines were not significantly different from zero for any PIPR metric indicating the PIPR amplitude is independent of age.

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus