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Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus

Relationship between age and the central retinal thickness (n = 59 participants).The solid line indicates the best-fitting linear regression. The F-value indicates the slope of the regression line does not change as a function of age.
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f3: Relationship between age and the central retinal thickness (n = 59 participants).The solid line indicates the best-fitting linear regression. The F-value indicates the slope of the regression line does not change as a function of age.

Mentions: A total of 59 participants (40 female, 19 male) were included in this study with an age range between 21 to 70 years (mean age ±SD: 43.7 ± 14.4 years) and there was equal distribution of participants in each age decade. The mean ± SD central retinal thickness was 272.72 ± 24.02 μm and the slope of the regression line (Fig. 3) was not significantly different from zero indicating that the central retinal thickness is independent of age in agreement with literature reports3940.


Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).

Adhikari P, Pearson CA, Anderson AM, Zele AJ, Feigl B - Sci Rep (2015)

Relationship between age and the central retinal thickness (n = 59 participants).The solid line indicates the best-fitting linear regression. The F-value indicates the slope of the regression line does not change as a function of age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664956&req=5

f3: Relationship between age and the central retinal thickness (n = 59 participants).The solid line indicates the best-fitting linear regression. The F-value indicates the slope of the regression line does not change as a function of age.
Mentions: A total of 59 participants (40 female, 19 male) were included in this study with an age range between 21 to 70 years (mean age ±SD: 43.7 ± 14.4 years) and there was equal distribution of participants in each age decade. The mean ± SD central retinal thickness was 272.72 ± 24.02 μm and the slope of the regression line (Fig. 3) was not significantly different from zero indicating that the central retinal thickness is independent of age in agreement with literature reports3940.

Bottom Line: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR).Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function.Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors.

View Article: PubMed Central - PubMed

Affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.

ABSTRACT
Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

No MeSH data available.


Related in: MedlinePlus