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Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.

Hung HC, Lu FH, Wu HT, Ou HY, Yang YC, Wu JS, Chang CJ - Sci Rep (2015)

Bottom Line: However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia.Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight.The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

ABSTRACT
Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta = -338.718, 95% CI = -552.786 ~ -124.651, p < 0.01), obese (beta = -530.275, 95% CI = -832.967 ~ -227.583, p < 0.01), and smoking (beta = -377.375, 95% CI = -654.353 ~ -100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

No MeSH data available.


Related in: MedlinePlus

Comparisons of cardiotrophin-1 levels among subjects who were normal weight, overweight, and obese.
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f1: Comparisons of cardiotrophin-1 levels among subjects who were normal weight, overweight, and obese.

Mentions: A total of 818 subjects who were normal weight (n = 522), overweight (n = 203), and obese (n = 93) were enrolled. The clinical characteristics of the study subjects are presented in Table 1. There were significant differences in age, BMI, SBP, DBP, FPG, PPG, insulin, HOMA-IR, triglyceride, HDL, ALT, AST levels, and the prevalence of female gender and hypertension among the three groups. The concentrations of cardiotrophin-1 were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in subjects who were normal weight, overweight, and obese, respectively (Fig. 1, ANOVA test p < 0.001, trend test p < 0.001). In the post hoc analysis, both subjects who were obese and overweight had significantly lower cardiotrophin-1 levels than those with normal weight.


Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.

Hung HC, Lu FH, Wu HT, Ou HY, Yang YC, Wu JS, Chang CJ - Sci Rep (2015)

Comparisons of cardiotrophin-1 levels among subjects who were normal weight, overweight, and obese.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664929&req=5

f1: Comparisons of cardiotrophin-1 levels among subjects who were normal weight, overweight, and obese.
Mentions: A total of 818 subjects who were normal weight (n = 522), overweight (n = 203), and obese (n = 93) were enrolled. The clinical characteristics of the study subjects are presented in Table 1. There were significant differences in age, BMI, SBP, DBP, FPG, PPG, insulin, HOMA-IR, triglyceride, HDL, ALT, AST levels, and the prevalence of female gender and hypertension among the three groups. The concentrations of cardiotrophin-1 were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in subjects who were normal weight, overweight, and obese, respectively (Fig. 1, ANOVA test p < 0.001, trend test p < 0.001). In the post hoc analysis, both subjects who were obese and overweight had significantly lower cardiotrophin-1 levels than those with normal weight.

Bottom Line: However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia.Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight.The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

ABSTRACT
Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta = -338.718, 95% CI = -552.786 ~ -124.651, p < 0.01), obese (beta = -530.275, 95% CI = -832.967 ~ -227.583, p < 0.01), and smoking (beta = -377.375, 95% CI = -654.353 ~ -100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

No MeSH data available.


Related in: MedlinePlus