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Influence of age, gender, and race on nitric oxide release over acupuncture points-meridians.

Ma SX, Lee PC, Jiang I, Ma E, Hu JS, Li XY - Sci Rep (2015)

Bottom Line: In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions.These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages.Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

View Article: PubMed Central - PubMed

Affiliation: LA BioMed Research Institute at Harbor-UCLA Medical Center and Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Torrance, CA 90502.

ABSTRACT
This study examined the influence of age, gender and race on nitric oxide (NO) release over acupuncture points, meridian without acupoint, and non-meridian regions of the Pericardium (PC) and Bladder (BL) meridian as well as aging on LU meridian in 61 healthy subjects. Biocapture tubes were attached to the skin surface, and total nitrite and nitrate was biocaptured and quantified using chemiluminescence. In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions. Conversely, NO content was elevated over BL regions only in overweight/obesity of elder ages. NO levels over PC regions were marginally elevated in overweight/obese males compared to females but did not alter between races. These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages. Increased NO levels along the BL meridian in older obese subjects may reflect a modified NO level along somatic-bladder pathway for counteracting bladder dysfunctions with aging. Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

No MeSH data available.


Related in: MedlinePlus

Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in Asian compared to white subjects.Concentrations of total nitrite plus nitrate (NOx−) were compared between Asian and white normal weight subjects over the regions along the Pericardium (PC) meridian (n = 16 and 6) and Bladder (BL) meridian (n = 9 and 5). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M.
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f4: Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in Asian compared to white subjects.Concentrations of total nitrite plus nitrate (NOx−) were compared between Asian and white normal weight subjects over the regions along the Pericardium (PC) meridian (n = 16 and 6) and Bladder (BL) meridian (n = 9 and 5). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M.

Mentions: NOx− concentrations were examined in six races along the skin surface of PC and BL regions in 50 healthy volunteers, as shown in Table 1. However, only Asian and white races have enough sample number for a comparison. Figure 4 shows NOx− concentrations over PC and BL acupoints, MWOP, and NMCR in Asian races compared to white in normal weight subjects. ANOVA analysis of NOx− concentrations over PC and BL regions in Asian compared to white subjects suggest no significant changes in NO release between the races.


Influence of age, gender, and race on nitric oxide release over acupuncture points-meridians.

Ma SX, Lee PC, Jiang I, Ma E, Hu JS, Li XY - Sci Rep (2015)

Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in Asian compared to white subjects.Concentrations of total nitrite plus nitrate (NOx−) were compared between Asian and white normal weight subjects over the regions along the Pericardium (PC) meridian (n = 16 and 6) and Bladder (BL) meridian (n = 9 and 5). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664911&req=5

f4: Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in Asian compared to white subjects.Concentrations of total nitrite plus nitrate (NOx−) were compared between Asian and white normal weight subjects over the regions along the Pericardium (PC) meridian (n = 16 and 6) and Bladder (BL) meridian (n = 9 and 5). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M.
Mentions: NOx− concentrations were examined in six races along the skin surface of PC and BL regions in 50 healthy volunteers, as shown in Table 1. However, only Asian and white races have enough sample number for a comparison. Figure 4 shows NOx− concentrations over PC and BL acupoints, MWOP, and NMCR in Asian races compared to white in normal weight subjects. ANOVA analysis of NOx− concentrations over PC and BL regions in Asian compared to white subjects suggest no significant changes in NO release between the races.

Bottom Line: In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions.These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages.Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

View Article: PubMed Central - PubMed

Affiliation: LA BioMed Research Institute at Harbor-UCLA Medical Center and Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Torrance, CA 90502.

ABSTRACT
This study examined the influence of age, gender and race on nitric oxide (NO) release over acupuncture points, meridian without acupoint, and non-meridian regions of the Pericardium (PC) and Bladder (BL) meridian as well as aging on LU meridian in 61 healthy subjects. Biocapture tubes were attached to the skin surface, and total nitrite and nitrate was biocaptured and quantified using chemiluminescence. In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions. Conversely, NO content was elevated over BL regions only in overweight/obesity of elder ages. NO levels over PC regions were marginally elevated in overweight/obese males compared to females but did not alter between races. These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages. Increased NO levels along the BL meridian in older obese subjects may reflect a modified NO level along somatic-bladder pathway for counteracting bladder dysfunctions with aging. Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

No MeSH data available.


Related in: MedlinePlus