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Influence of age, gender, and race on nitric oxide release over acupuncture points-meridians.

Ma SX, Lee PC, Jiang I, Ma E, Hu JS, Li XY - Sci Rep (2015)

Bottom Line: In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions.These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages.Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

View Article: PubMed Central - PubMed

Affiliation: LA BioMed Research Institute at Harbor-UCLA Medical Center and Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Torrance, CA 90502.

ABSTRACT
This study examined the influence of age, gender and race on nitric oxide (NO) release over acupuncture points, meridian without acupoint, and non-meridian regions of the Pericardium (PC) and Bladder (BL) meridian as well as aging on LU meridian in 61 healthy subjects. Biocapture tubes were attached to the skin surface, and total nitrite and nitrate was biocaptured and quantified using chemiluminescence. In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions. Conversely, NO content was elevated over BL regions only in overweight/obesity of elder ages. NO levels over PC regions were marginally elevated in overweight/obese males compared to females but did not alter between races. These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages. Increased NO levels along the BL meridian in older obese subjects may reflect a modified NO level along somatic-bladder pathway for counteracting bladder dysfunctions with aging. Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

No MeSH data available.


Related in: MedlinePlus

Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in elder subjects compared to adults.(a) Concentrations of total nitrite plus nitrate (NOx−) wee compared in adults vs. elder subjects over the skin regions along the Pericardium meridian (PC, n = 14 and 10), Bladder meridian (BL, n = 12 and 7), and Lung meridian (LU, n = 14 and 8). (b) NOx− concentrations over LU regions were compared in normal weight adult vs. elder subjects (n = 10 and 16). (c) NOx− concentrations over BL regions were compared between adult and elder subjects in normal weight (n = 12 and 6) and in overweight/obesity (n = 12 and 7). (d) NOx− concentrations over PC regions were compared between adult and elder subjects in normal weight (n = 16 and 8) and in overweight/obesity (n = 12 and 10). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M. *p < 0.05, compared to adult; #p < 0.10, compared to adult.
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f2: Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in elder subjects compared to adults.(a) Concentrations of total nitrite plus nitrate (NOx−) wee compared in adults vs. elder subjects over the skin regions along the Pericardium meridian (PC, n = 14 and 10), Bladder meridian (BL, n = 12 and 7), and Lung meridian (LU, n = 14 and 8). (b) NOx− concentrations over LU regions were compared in normal weight adult vs. elder subjects (n = 10 and 16). (c) NOx− concentrations over BL regions were compared between adult and elder subjects in normal weight (n = 12 and 6) and in overweight/obesity (n = 12 and 7). (d) NOx− concentrations over PC regions were compared between adult and elder subjects in normal weight (n = 16 and 8) and in overweight/obesity (n = 12 and 10). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M. *p < 0.05, compared to adult; #p < 0.10, compared to adult.

Mentions: NOx− concentrations over LU, PC, and BL regions were examined in elder (age: 40–75 years) compared to adult (age: 18–39 years) groups in 61 healthy volunteers (Fig. 2a). ANOVA analysis of NOx− concentrations biocaptured over LU regions in two age groups suggest a significant reduction of NO metabolites in the elder ages compared to adults (F1,12 = 7.5, P = 0.02). In contrast to LU regions, there were no detectable changes in NO content over PC regions in the elder ages compared to adults. NO levels over LU MWOP and NMCR were significantly decreased in elder compared to adult subjects (P < 0.01). NO content over LU acupoints tended to be reduced in elder compared to adult subjects, but fell short of statistical significance (P = 0.12).


Influence of age, gender, and race on nitric oxide release over acupuncture points-meridians.

Ma SX, Lee PC, Jiang I, Ma E, Hu JS, Li XY - Sci Rep (2015)

Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in elder subjects compared to adults.(a) Concentrations of total nitrite plus nitrate (NOx−) wee compared in adults vs. elder subjects over the skin regions along the Pericardium meridian (PC, n = 14 and 10), Bladder meridian (BL, n = 12 and 7), and Lung meridian (LU, n = 14 and 8). (b) NOx− concentrations over LU regions were compared in normal weight adult vs. elder subjects (n = 10 and 16). (c) NOx− concentrations over BL regions were compared between adult and elder subjects in normal weight (n = 12 and 6) and in overweight/obesity (n = 12 and 7). (d) NOx− concentrations over PC regions were compared between adult and elder subjects in normal weight (n = 16 and 8) and in overweight/obesity (n = 12 and 10). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M. *p < 0.05, compared to adult; #p < 0.10, compared to adult.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664911&req=5

f2: Quantification of nitric oxide (NO) metabolites over skin acupoints/meridians in elder subjects compared to adults.(a) Concentrations of total nitrite plus nitrate (NOx−) wee compared in adults vs. elder subjects over the skin regions along the Pericardium meridian (PC, n = 14 and 10), Bladder meridian (BL, n = 12 and 7), and Lung meridian (LU, n = 14 and 8). (b) NOx− concentrations over LU regions were compared in normal weight adult vs. elder subjects (n = 10 and 16). (c) NOx− concentrations over BL regions were compared between adult and elder subjects in normal weight (n = 12 and 6) and in overweight/obesity (n = 12 and 7). (d) NOx− concentrations over PC regions were compared between adult and elder subjects in normal weight (n = 16 and 8) and in overweight/obesity (n = 12 and 10). NOx− concentrations (nmol/cm2) were obtained over acupoints, meridian lines without acupoint (MWOP), and non-meridian control region (NMCR). Each bar represents the mean values and vertical bars represent S.E.M. *p < 0.05, compared to adult; #p < 0.10, compared to adult.
Mentions: NOx− concentrations over LU, PC, and BL regions were examined in elder (age: 40–75 years) compared to adult (age: 18–39 years) groups in 61 healthy volunteers (Fig. 2a). ANOVA analysis of NOx− concentrations biocaptured over LU regions in two age groups suggest a significant reduction of NO metabolites in the elder ages compared to adults (F1,12 = 7.5, P = 0.02). In contrast to LU regions, there were no detectable changes in NO content over PC regions in the elder ages compared to adults. NO levels over LU MWOP and NMCR were significantly decreased in elder compared to adult subjects (P < 0.01). NO content over LU acupoints tended to be reduced in elder compared to adult subjects, but fell short of statistical significance (P = 0.12).

Bottom Line: In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions.These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages.Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

View Article: PubMed Central - PubMed

Affiliation: LA BioMed Research Institute at Harbor-UCLA Medical Center and Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Torrance, CA 90502.

ABSTRACT
This study examined the influence of age, gender and race on nitric oxide (NO) release over acupuncture points, meridian without acupoint, and non-meridian regions of the Pericardium (PC) and Bladder (BL) meridian as well as aging on LU meridian in 61 healthy subjects. Biocapture tubes were attached to the skin surface, and total nitrite and nitrate was biocaptured and quantified using chemiluminescence. In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions. Conversely, NO content was elevated over BL regions only in overweight/obesity of elder ages. NO levels over PC regions were marginally elevated in overweight/obese males compared to females but did not alter between races. These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages. Increased NO levels along the BL meridian in older obese subjects may reflect a modified NO level along somatic-bladder pathway for counteracting bladder dysfunctions with aging. Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

No MeSH data available.


Related in: MedlinePlus